- Four-year study involved more than 1,000 dialysis patients from a large dialysis provider in Colombia
- Study compared Baxter’s HDx therapy enabled by Theranova dialyzer with high-flux hemodialysis
Saturday, June 1, 2024
Baxter Hemodialysis Therapy Linked to 25% Lower Mortality Rate for up to Four Years
KalVista Publishes Phase 3 Data Demonstrating its Potential Treatment in Hereditary Angioedema
Late-breaking data from phase 3 KONFIDENT trial of sebetralstat published in NEJM and presented concurrently at the European Academy of Allergy and Clinical Immunology Congress 2024 –
– Interim data from KONFIDENT-S open-label trial show median time to treatment of 9 minutes and median time to beginning of symptom relief for laryngeal attacks 1.3 hours –
Certain Restricted Stock Units of Tarsus Pharmaceuticals, Inc. are subject to a Lock-Up Agreement Ending
Certain Restricted Stock Units of Tarsus Pharmaceuticals, Inc. are subject to a Lock-Up Agreement Ending on 31-MAY-2024. These Restricted Stock Units will be under lockup for 91 days starting from 1-MAR-2024 to 31-MAY-2024.
Details:
The company, it's executive officers and directors and certain of stockholders have agreed that, subject to certain exceptions, during the period ending 90 days after the date of this prospectus supplement, will not offer, sell, dispose of or hedge any shares of common stock or securities convertible into or exchangeable for shares of common stock, subject to specified limited exceptions.
Iterum Acceptance of Resubmission for treatment of Uncomplicated Urinary Tract Infections
Iterum Therapeutics plc (Nasdaq: ITRM) (the Company), a clinical-stage pharmaceutical company focused on developing next generation oral and IV antibiotics to treat infections caused by multi-drug resistant pathogens in both community and hospital settings, today announced that the U.S. Food and Drug Administration (FDA) has acknowledged receipt of the resubmission of the New Drug Application (NDA) for sulopenem etzadroxil/probenecid (oral sulopenem) for the treatment of uncomplicated urinary tract infections (uUTIs) in adult women. Under the Prescription Drug User Fee Act (“PDUFA”), the FDA has deemed the Company’s NDA resubmission to be a Class II complete response which has a six-month review period from the date of resubmission. As a result, the FDA has assigned a PDUFA action date of October 25, 2024.
Autolus analysis of Pivotal Phase 2 FELIX study of obe-cel for adult r/r B-ALL
- The majority of patients that responded to obe-cel showed durable responses with the potential for a long-term plateau of survival outcomes
- 40% patients are in ongoing remission without subsequent stem cell transplant (SCT) or other intervention
- Ongoing CAR T persistence was associated with improved event-free survival
- Autolus will host a conference call and webcast to discuss the presented data on Saturday June 1, 2024 at 9:30 am EDT/8:30 am CDT/2:30 pm BST (details below)
A conference call and webcast to discuss the presented data will be held at 9:30 am EDT/8:30 am CDT/2:30 pm BST on Saturday June 1, 2024. Conference call participants should pre-register using this link to receive the dial-in numbers and a personal PIN, which are required to access the conference call.
A simultaneous audio webcast and replay will be accessible on the events section of Autolus’ website.
Nvidia soon to join Dow?
Is Nvidia about to reach a new milestone by joining the Dow Jones, the most exclusive and longest-running index on the US stock market? The question arises in view of the company's weight on the stock market and its importance in the global ecosystem. The forthcoming ten-for-one stock split may well help the decision. But nothing has yet been done.
A company's inclusion in the Dow Jones Industrial Average (DJIA) is a milestone for US-listed companies. Wall Street's oldest index comprises just 30 stocks, and changes are relatively rare (7 in the last 15 years). Inclusions and exclusions are subject to a number of criteria, not all of which are explicitly defined, as selection is partly subjective (no numerical criteria, apart from share price, as we shall see later) and carried out by a special committee of S&P Dow Jones Indices. Here are a few criteria:
- The company has an "excellent reputation".
- Sustained growth
- Attractive to a large number of investors
- Maintains "adequate" sector representation
- It must be incorporated and headquartered in the United States, and generate "a significant portion" of its revenues there.
- It does not belong to the Transportation (GICS code 2030) or Utilities (GICS code 55) sectors.
- The most expensive stock in the index must not be more than ten times more expensive than the cheapest.
Nvidia is a candidate for inclusion in the index, given its growth over the past two decades and its position as one of the fastest-growing companies in the United States. Based on current share prices (USD 1141), the operation would not have been possible under the last of the aforementioned laws. But Nvidia has announced its intention to divide the value of its stock by ten, to make it more accessible, more liquid and... perhaps to set its sights on the Dow Jones? The index is in fact weighted by price - an incongruity in modern times - and not by capitalization. S&P can't afford to include stocks whose price is too high, at the risk of giving them too much influence in the index. On the basis of the current price of USD 1141, a tenfold split would bring the price down to around USD 114, which would be much more acceptable for inclusion in the Dow Jones. Currently, the Dow's most influential stock is UnitedHealth (USD 504), ahead of The Goldman Sachs Group (USD 460) and Microsoft (USD 430).
The market had speculated that Amazon would enter the Dow in 2022, after a "split". The stock was finally added earlier this year, at the expense of Walgreens Boots (which had ousted General Electric in 2018). In the technology segment, Microsoft and Intel had joined the index in 1999, becoming the first Nasdaq-listed stocks to be included in the Dow. Apple had to wait until 2015 (replacing AT&T).
Many positive arguments
Nvidia has the potential to join the Dow Jones, but the final decision is partly discretionary, as we've seen. Changes are not that frequent in the old index. Even so, the forecasts make Intel a risky proposition. The company has not been on a roll for some time now, and is at the very bottom of the rankings in terms of share price (USD 31). What's more, it seems easier to replace a technology with a technology for the committee: it avoids having to rack your brains over sector representativeness!
The stock ticks quite a few boxes in favor of inclusion. But perhaps the committee will want to wait for the dust to settle after the stock's stratospheric rise (it can decide when it likes). On the other hand, Nvidia's entry into the Dow would enable the old index to better replicate the strength of the technology sector, since Intel hasn't been the best horse to bet on in this area in recent years. Several market insiders punctuated their comments on the subject with this mantra, which pretty much sums up the general feeling: it's not a question of if Nvidia will enter the Dow, but when.
Here it is: 'Trump supporters call for riots and violent retribution after verdict'
Supporters of former President Donald Trump, enraged by his conviction on 34 felony counts by a New York jury, flooded pro-Trump websites with calls for riots, revolution and violent retribution.
After Trump became the first U.S. president to be convicted of a crime, his supporters responded with dozens of violent online posts, according to a Reuters review of comments on three Trump-aligned websites: the former president's own Truth Social platform, Patriots.Win and the Gateway Pundit.
Some called for attacks on jurors, the execution of the judge, Justice Juan Merchan, or outright civil war and armed insurrection.
“Someone in NY with nothing to lose needs to take care of Merchan,” wrote one commentator on Patriots.Win. “Hopefully he gets met with illegals with a machete,” the post said in reference to illegal immigrants.
On Gateway Pundit, one poster suggested shooting liberals after the verdict. “Time to start capping some leftys,” said the post. “This cannot be fixed by voting."
Threats of violence and intimidating rhetoric soared after Trump lost the 2020 election and falsely claimed the vote was stolen. As he campaigns for a second White House term, Trump has baselessly cast the judges and prosecutors in his trials as corrupt tools of the Biden administration, intent on sabotaging his White House bid. His loyalists have responded with a campaign of threats and intimidation targeting judges and court officials.
“This was a disgrace, this was a rigged trial by a conflicted judge who was corrupt,” Trump told reporters afterwards, echoing comments he often made during the trial.
A 12-member jury found Trump guilty on Thursday of falsifying documents to cover up a payment to silence a porn star’s account of a sexual encounter ahead of the 2016 election. Sentencing is set for July 11, days before the Republican Party is scheduled to formally nominate Trump for president ahead of the Nov. 5 election. Trump has denied wrongdoing and is expected to appeal.
Trump continued his attacks online after the verdict.
On Truth Social, he called Merchan “HIGHLY CONFLICTED” and criticized his jury instructions as unfair. One commentator responded by posting a picture of a hangman's platform and a noose with the caption: “TREASONOUS MOBSTER OF THE JUSTICES SYSTEM!!”
Jacob Ware, a co-author of the book “God, Guns, and Sedition: Far-Right Terrorism in America”, said the violent language used by Trump’s followers was testament to the former president’s “ironclad ability to mobilize more extreme supporters to action, both at the ballot box and through violence.”
“Until and unless he accepts the process, the extremist reaction to his legal troubles will be militant,” said Ware, a research fellow at the Council on Foreign Relations.
A spokesperson for Truth Social said, “It’s hard to believe that Reuters, once a respected news service, has fallen so low as to publish such a manipulative, false, defamatory and transparently stupid article as this one purely out of political spite.”
All three sites have policies against violent language, and some of the posts were later removed. Representatives of Patriots.Win and Gateway Pundit did not immediately return requests for comment. A Trump spokesperson also did not respond to an email seeking comment.
“HANG EVERYONE”
After Thursday's verdict, many of his supporters also said that his conviction was proof that the American political system was broken and that only violent action could save the country.
“1,000,000 men (armed) need to go to Washington and hang everyone. That's the only solution,” said one poster on Patriots.win. Another added: “Trump should already know he has an army willing to fight and die for him if he says the words...I’ll take up arms if he asks.”
Other posts specifically urged targeting Democrats, in some cases suggesting they be shot. “AMERICA FULLY DESTROYED BY DEMOCRATS. LOCK AND LOAD,” wrote a commentator on Gateway Pundit.
While the posts identified by Reuters all called for violence or insurrection, most fell short of the legal standard for a prosecutable threat, which typically requires evidence that the comment reflects a clear intent to act or instill fear, rather than simply suggesting a frightening outcome.
Still, one researcher who studies extremist militias said the guilty verdict could inspire violence by reinforcing a conviction among some of Trump's supporters that he's a victim of a conspiracy orchestrated by his enemies.
“I do think a lot of these folks have been looking for an excuse to maybe mobilize for a while,” said Amy Cooter of the Middlebury Institute of International Studies’ Center on Terrorism, Extremism and Counterterrorism. “I hope I’m wrong. I’ve said for a long time, though, that I would not be shocked to see violence result from a guilty verdict, either directed toward the jurors” or others connected to the case.
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