OCS-01 Phase 3 DIAMOND trials miss primary vision endpoint, prompting no FDA filing

 

• Oculis announced May 29, 2026 that both DIAMOND-1 and DIAMOND-2 Phase 3 trials of OCS-01 eye drops in DME failed primary BCVA change from baseline at week 52.
• Key secondary endpoint (proportion with ≥15-letter BCVA gain) also missed in both trials despite substantial retinal thickness reduction vs vehicle.
• OCS-01 was well-tolerated with safety consistent with prior studies; no unexpected adverse events.
• Company stated it will not pursue FDA regulatory filing for OCS-01 in DME and is redirecting resources to Privosegtor (optic neuropathies PIONEER program) and Licaminlimab (dry eye PREDICT-1).
• CEO Riad Sherif: "disappointed that the substantial and sustained reduction in retinal thickness... didn’t translate into BCVA improvement at week 52."
• $278M cash provides runway into 2H 2029, supporting continued late-stage pipeline execution.
• Stock fell ~23% on May 29 (close ~$22.71 from $29.65) with further extended-hours decline reaching ~34% drop, matching the reported premarket move.

https://finviz.com/stock?t=OCS&p=d

GNTA surges in premarket on completion of full A.T.C. acquisition

 

GNTA surges 33% in premarket on completion of full A.T.C. acquisition

• Genenta closed acquisition of remaining 80.5% of A.T.C. S.r.l. on May 29, 2026 before Italian notary.
• €9.6M purchase settled via issuance of 24.6M new shares at €0.39 each to sellers.
• Deal gives Genenta 100% ownership of profitable defense/tech firm with €4M projected 2026 revenue and >€2M EBITDA.
• Advances transformation into Saentra Forge, industrial consolidator targeting defense, aerospace, national security.
• Sellers subject to 36-month lock-up on shares, with price protection options but no governance rights.
• Builds on January 2026 strategic pivot; recent 15% gain on May 29 close shows building momentum.

https://finviz.com/stock?t=GNTA&p=d

Ryabkov: Russia, Cuba to cooperate in energy

 Russian Deputy Foreign Minister Sergey Ryabkov stated on Monday that cooperation between Russia and Cuba continues "in all areas," and that the two countries will continue work on joint projects.

"A number of promising joint projects in energy, metallurgy, transportation, agriculture, biopharmaceuticals and biotechnology, information and communications technology, and education are being developed and are already under implementation," Ryabkov said at the opening of the exhibition dedicated to Cuban revolutionaries in Moscow.

Russian officials have repeatedly shown support for the island nation amid the American blockade of energy. Earlier, Moscow condemned the indictment of Cuba's former President Raul Castro.

https://breakingthenews.net/Article/Ryabkov:-Russia-Cuba-to-cooperate-in-energy/66410138

IDF orders evacuation of Beirut's southern outskirts

The Israel Defense Forces (IDF) issued an evacuation warning to residents of Beirut's southern suburbs ahead of airstrikes.

"If the terrorist Hezbollah continues launching rockets towards Israeli cities and towns, the Defense Army will respond by targeting objectives in the southern Dahiya," IDF spokesperson Avichay Adraee wrote on X, stressing that Israel is not fighting Lebanese people but the military group.

The Israeli army reported earlier today that its troops eliminated three Hezbollah operatives in southern Lebanon yesterday.

https://breakingthenews.net/Article/IDF-orders-evacuation-of-Beirut's-southern-outskirts/66410020

WTI surges over 7.5% amid Iran escalation fears

 The prices of oil futures continued to move upward on Monday, with the West Texas Intermediate (WTI) rallying over 7.5% after media reported that Tehran would stop negotiations with the United States over Israel's latest military actions in Lebanon, and completely close the Strait of Hormuz. Iran and the US also recently exchanged strikes, further bringing the stability of the region into question.

WTI for July deliveries soared 7.80% at 10:16 am ET, going for $94.19 per barrel. At the same time, Brent for the August settlements soared 6.69%, selling at $97.22 a barrel.

https://breakingthenews.net/Article/WTI-surges-over-7.5-amid-Iran-escalation-fears/66410053

US downs 2 Iranian missiles targeting Kuwait base

 The United States Central Command (CENTCOM) claimed on Monday that its forces "successfully intercepted" and "immediately defeated" two Iranian ballistic missiles targeting American forces stationed in Kuwait. The agency added that no US personnel were harmed.

"US Central Command remains vigilant and will continue to protect our forces from Iranian aggression while supporting the ongoing ceasefire," CENTCOM wrote in an X post.

The attacks came after the US claimed to have carried out "self-defense strikes on Iranian radar and command and control sites for drones" over the weekend in retaliation for earlier Iranian aggressions.

https://breakingthenews.net/Article/US-downs-2-Iranian-missiles-targeting-Kuwait-base/66408621

Iran said to halt US talks, completely close Hormuz

 Iran ended the negotiations with the United States over Israeli strikes on Lebanon and will completely shut the Strait of Hormuz, Iranian Tasnim News Agency reported on Monday.

According to the outlet, Tehran suspended "talks and exchanges of messages through mediators" due to "continued crimes of the Zionist regime in Lebanon," as the resolution of the Lebanon crisis was one of Iran's preconditions for peace. The Iranian side accused the US of "violating the ceasefire on all fronts."

Tehran is said to completely shut the critical Strait of Hormuz, as well as the Bab el-Mandeb Strait, in order to "punish the Zionists and their supporters."

https://breakingthenews.net/Article/Iran-said-to-halt-US-talks-completely-close-Hormuz/66409600