Bicycle Therapeutics, a biotechnology company pioneering a new class of therapeutics based on its proprietary bicyclic peptide (Bicycle®) product platform, today announced the receipt of a milestone payment in connection with the initiation of a Phase 1 clinical study evaluating THR-149, under its ophthalmology alliance with ThromboGenics NV (Euronext Brussels: THR), a biopharmaceutical company focused on developing treatments for vitreo-retinal disorders.
THR-149 is a novel plasma kallikrein inhibitor identified and optimized by the Bicycle technology platform. The open-label, multicenter, dose escalation study will evaluate the safety of intravitreally administered THR-149 for the treatment of diabetic macular edema (DME). Initial study results are anticipated in mid-2019.
In addition, Bicycle Therapeutics announced the expansion of the alliance, which aims to identify and optimise additional Bicycles for the treatment of ophthalmic diseases.
“As the second Bicycle in the clinic, THR-149 will enable us to further evaluate the tremendous potential for Bicycles to treat significant human diseases with unmet need,” said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. “Our decision to expand our alliance is a testament to both the highly collaborative nature of the relationship and our ability to develop novel Bicycles as therapeutics for patients with ophthalmic diseases. We are excited to continue our work with ThromboGenics to develop innovative therapeutics.”
“Bicycles have unique properties that make them particularly suited for diabetic macular edema (DME),” said Patrik De Haes, M.D., Chief Executive Officer of ThromboGenics. “Progressing THR-149 to the clinic is a significant achievement and marks an important milestone in our collaborative efforts to bring novel treatments to patients suffering from diseases of the eye. We are excited to build on the learnings we have made in our existing partnership with Bicycle in our extended collaboration.”
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