Oasmia reported its analysis of the data from the Phase II study and it’s the follow-up has been finalized and summarized in a report. Overall, 17 dogs participated and were treated with Doxophos Vet in the main study and eight of these continuing during the follow-up part. The objective was obtained, as 75% of the dogs with B-cell lymphoma showed a response after at least two treatment cycles. Progression free survival was defined as the time from screening to progression, or death of any cause. The study results confirmed that the dose of Doxophos Vet defined in a prior dose-finding study is appropriate with regards to both efficacy and safety in dogs with lymphoma. The pharmacokinetic profile analyzed shows there is a rapid distribution of doxorubicin into the tissues, and that the Doxophos Vet formulation does not alter the release properties of doxorubicin when infused into the blood. The most frequently reported adverse reaction after Doxophos Vet treatment was myelosuppression. This is the most expected adverse reaction with chemotherapy. Of the majority of the adverse events, 88% in the main study and 69% in the follow-up were mild to moderate.
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