Acceleron announced it is discontinuing development of ACE-2494, a systemic muscle agent the company had been studying in a Phase 1 healthy volunteer trial for the potential treatment of neuromuscular disorders. “Although ACE-2494 showed promising early signs of target engagement in our recently completed Phase 1 trial, the frequency of anti-drug antibodies (ADAs) observed among participants has led us to discontinue the program,” said Habib Dable, President and Chief Executive Officer of Acceleron. “The formation of ADAs was not associated with any adverse event, but the ADA profile is not consistent with a clinical program that Acceleron would advance. ”
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