Favorable safety and tolerability profile– Superior antiviral activity with ABI-H0731 in combination with nucleos(t)ide therapies– Selected for inclusion in “Best of ILC” presentation– Company to host conference call Monday, April 15, 2019 at 8am EDT
Assembly Biosciences, Inc. (NASDAQ: ASMB), a clinical-stage biotechnology company developing innovative therapeutics targeting hepatitis B virus (HBV) and diseases associated with the microbiome, presented interim results from two Phase 2a clinical trials of ABI-H0731 (731), a novel antiviral in development for the treatment of chronic HBV infection. The data were presented during a late-breaker oral session on Saturday, April 13, 2019, at The International Liver Congress™(ILC), the Annual Meeting of the European Association for the Study of the Liver (EASL) in Vienna, Austria. The late-breaker abstract was also selected for inclusion in the ‘Best of ILC’ presentation as well as for press release coverage at ILC 2019. A copy of the presentation will be posted to the Events & Presentations page in the Investors section of the company’s website at assemblybio.com.
“This interim analysis of two Phase 2a studies supports that 731 in combination with nucleos(t)ide therapy (Nucs) demonstrates rapid and enhanced anti-HBV activity,” said Dr. Jacob Lalezari, of Quest Clinical Research in San Francisco. “The data we have seen thus far are directionally correct and decreases in HBeAg and HBsAg have been observed in some individuals in both studies. The accelerated decline and significant loss of baseline RNA and DNA viremia suggest that combination therapy with a core inhibitor + Nuc has the potential to significantly advance treatments for patients with HBV.”
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