Iterum Therapeutics will present three posters at the European Congress of Clinical Microbiology & Infectious Diseases, or ECCMID. The authors reviewed the records of 4,792 patients given oral antibiotics for uncomplicated urinary tract infections, or uUTIs, and assessed the difference in 28-day outcomes for patients with a uUTI whose pathogens were susceptible to empiric therapy versus those who were non-susceptible to therapy, highlighting the risk factors associated with failure. They concluded the most significant risk for treatment failure is treatment of the index infection with an antibiotic to which the organism in a prior infection was resistant. Age, gender and diabetes mellitus also increased the likelihood of treatment failure. Treatment failure and hospitalization rates double with mismatched empiric antibiotic therapy. The more antibiotic class resistance, the higher likelihood of treatment failure.
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