SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology company delivering innovative therapies for difficult-to-treat and often life-threatening infections, today announced results showing evidence of activity of the company’s lead product candidate, ibrexafungerp, against fungal infections in multiple settings and indications. These include case studies showing treatment with oral ibrexafungerp resulting in full clearance of Candida auris infections. The findings were described in one oral presentation and five poster presentations at the 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), April 13-16, 2019, in Amsterdam, Netherlands.
“We are encouraged by the data shared at ECCMID 2019 and ibrexafungerp’s potential to be a new treatment in the fight against difficult-to-treat and resistant fungal infections,” said David Angulo, M.D., Chief Medical Officer of SCYNEXIS. “This additional evidence of clinical activity of ibrexafungerp in a variety of infection types further highlights its versatility and its potential to address unmet needs. We are heartened by the recent attention given to Candida auris, as we believe that increased awareness combined with new treatments are the keys to success in the fight against this serious global health threat.”
The five ibrexafungerp poster presentations are as follows:
- Successful Treatment of Two Patients with Candida auris Candidemia with the Investigational Agent, Oral Ibrexafungerp (formerly SCY-078) from the CARES Study (#L0028 – Deven Juneja, MD)
- Favourable Clinical Outcome of Two Patients with Candida spp. Spondylodiscitis Treated with Oral Ibrexafungerp (formerly SCY-078) from the FURI Study (#L0033 –Philipp Koehler, MD)
- Use of Ibrexafungerp (formerly SCY-078) to Treat Severe Azole-refractory Oesophageal Candidiasis: A Case Report from the FURI Study (#P0125 – Jose Vazquez, MD)
- Penetration of Ibrexafungerp (formerly SCY-078) versus Micafungin at the Site of Infection in an Intra-abdominal Candidiasis Mouse Model (#O0740 – Annie Lee, PhD)
- Efficacy of Ibrexafungerp (formerly SCY-078) against Pneumocystis Pneumonia in a Murine Therapeutic Model (#O0733 – Stephen Barat, PhD)
The ECCMID 2019 posters are available on the SCYNEXIS website and on the ECCMID 2019 website.
One oral presentation (#L0010), showcasing results from the first interim analysis of 20 patients with various Candida infections from the FURI study will be given by Dr. Oliver Cornely on Tuesday, April 16, from 11:00-12:00 CET.
Conference Call Details
SCYNEXIS will hold a conference call today at 4:15 p.m. ET to discuss the ibrexafungerp data presented at ECCMID 2019. SCYNEXIS management will be joined by the following global thought leaders:
- Oliver Cornely, M.D., Professor of Internal Medicine and Medical Director, Clinical Trials Center Cologne at the University of Cologne in Germany;
- Jose Vazquez, M.D., Division Chief and Professor of Medicine and Infectious Diseases, Augusta University, Georgia; and
- Deven Juneja, M.D., Assistant Professor, Department of Critical Care at the Max Super Specialty Hospital in New Delhi, India. Due to prior commitments, Dr. Juneja is unable to join today’s call but kindly recorded his remarks.
U.S. Dial-in Number: 844-309-3707
International Dial-In Number: 661-378-9467
Conference ID: 2870577
The slide and audio webcast can be accessed by visiting the Investors section of the Company’s website at http://ir.scynexis.com. A replay of the webcast will be available shortly after the conclusion of the call and will be archived on the Company’s website for 30 days.
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