Blueprint Med Shows Anti-Tumor Activity in Updated Trial Data Presented at ASCO

— 60% ORR in post-platinum RET-fusion NSCLC and 63% ORR in RET-mutant MTC patients previously treated with multi-kinase inhibitors; median durations of response not reached —

— Responses observed across treatment-naïve and previously treated patients, and regardless of RET alteration or tumor type —

— Strong activity against brain metastases in NSCLC patients —

— Plan to submit initial NDA to FDA for BLU-667 in RET-fusion NSCLC in first quarter of 2020 —

— Blueprint Medicines to host investor event and webcast on Monday, June 3, 2019 at 6:30 p.m. CT —

Blueprint Medicines Corporation (NASDAQ: BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, today announced updated data from the ongoing registration-enabling ARROW trial of BLU-667 in patients with RET-altered cancers. The data presented at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting show durable clinical activity in patients with RET-altered non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and other cancers. Designed by Blueprint Medicines, BLU-667 is a potent and highly selective oral inhibitor of RET fusions and mutations, including predicted resistance mutations.

Blueprint Medicines will host an investor event on Monday, June 3, 2019 beginning at 6:00 p.m. CT (7:00 p.m. ET) in Chicago to provide a portfolio update, including a review of updated clinical data from the ongoing ARROW trial of BLU-667 in patients with RET-altered cancers and the ongoing registration-enabling NAVIGATOR trial in patients with PDGFRA Exon 18 mutant and fourth-line gastrointestinal stromal tumors (GIST). Formal presentations and the live webcast will begin at 6:30 p.m. CT (7:30 p.m. ET). The event will be webcast live and can be accessed under the “Investors & Media—Events & Presentations” section of Blueprint Medicines’ website at www.BlueprintMedicines.com. A replay of the webcast will be available approximately two hours after the event and will be available for 30 days following the event.

https://www.prnewswire.com/news-releases/blueprint-medicines-highly-selective-ret-inhibitor-blu-667-shows-durable-anti-tumor-activity-in-patients-with-ret-altered-cancers-in-updated-arrow-trial-data-presented-at-asco-2019-300860552.html