Deciphera expands cancer pipeline

– DCC-3116 Selectively Targets ULK Kinase, an Initiating Protein that Activates Autophagy –

– Company to Host a Webcast on Tuesday, June 18, 2019 at 8 a.m. ET to Discuss Autophagy Inhibition and the Treatment of Mutant RAS Cancers –

Deciphera Pharmaceuticals, Inc. (DCPH) today announced the addition of a new candidate to its pipeline, DCC-3116, a potential first-in-class small molecule designed to inhibit cancer autophagy, a key tumor survival mechanism. DCC-3116, discovered using the Company’s novel switch control inhibitor platform, is designed to inhibit autophagy by inhibiting the ULK kinase. Autophagy is a cellular pathway that has been shown to be upregulated in mutant RAS cancers and that also mediates resistance to inhibitors of the RAS signaling pathway. Subject to favorable investigational new drug (IND)-enabling studies and filing and activation of an IND, Deciphera intends to develop DCC-3116 for the potential treatment of mutant RAS cancers in combination with inhibitors of downstream effector targets including RAF, MEK, or ERK inhibitors as well as with direct inhibitors of mutant RAS.

DCC-3116 Event and Webcast Information

Deciphera will host a live event and webcast to discuss the new program on Tuesday, June 18, 2019 at 8 a.m. ET. The event will feature members of the Deciphera management team and Channing Der, Ph.D., Sarah Graham Kenan Distinguished Professor, Department of Pharmacology, UNC School of Medicine, who is a leading expert in mutant RAS cancers and autophagy.

A live audio webcast of the event and accompanying slides may be accessed through the Investors section of Deciphera’s website at www.deciphera.com. A replay of the webcast will be available for 30 days following the event.

https://finance.yahoo.com/news/deciphera-pharmaceuticals-inc-expands-pipeline-110000100.html