Results from several studies of Eli Lilly and Company’s (LLY) investigational dual GIP and GLP-1 receptor agonist (RA), tirzepatide, reinforce its potential in lowering A1C and body weight in people with type 2 diabetes. Early research results also support tirzepatide’s potential benefit in treating other metabolic conditions. The following findings were presented in oral and poster presentations at the American Diabetes Association’s® 79th Scientific Sessions® in San Francisco:
- improvements in markers of beta cell function (how cells in the pancreas produce, store and release insulin) and insulin sensitivity (how cells in the body respond to insulin) that help explain efficacy;1
- efficacy and improved tolerability with lower initial doses and smaller subsequent dose escalations;2
- significant A1C and body weight reductions in Japanese people with type 2 diabetes after just eight weeks of treatment;3 and
- improvements in markers of non-alcoholic steatohepatitis (NASH, liver inflammation and cell damage caused by liver fat) in people with type 2 diabetes.4
“These new tirzepatide data build upon the positive results seen in people with type 2 diabetes to date,” said Juan P. Frias, M.D., Medical Director and Principal Investigator, National Research Institute. “The results offer additional evidence of tirzepatide’s potential to meaningfully reduce A1C and body weight in people with type 2 diabetes and treat other metabolic conditions.”
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