Hui Xu, MSc1; Rongrong Yang, MSc1; Xiuying Qi, PhD1; et alChristina Dintica, MSc2; Ruixue Song, MSc1; David A. Bennett, MD3; Weili Xu, MD, PhD1,2
JAMA Neurol. Published online July 14, 2019. doi:10.1001/jamaneurol.2019.2455
Key PointsQuestion Is high lifespan cognitive reserve (CR) indicator associated with a reduction in dementia risk, and how strong is this association in the presence of high brain pathologies?
Findings In this cohort study including 1602 dementia-free older adults, high lifespan CR was associated with a decreased risk of dementia. This association was present in people with high Alzheimer disease and vascular pathologies.
Meaning Accumulative educational and mentally stimulating activities enhancing CR throughout life might be a feasible strategy to prevent dementia, even for people with high brain pathologies.
Abstract
Importance Evidence on the association of lifespan cognitive reserve (CR) with dementia is limited, and the strength of this association in the presence of brain pathologies is unknown.
Objective To examine the association of lifespan CR with dementia risk, taking brain pathologies into account.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.