Cortexyme To Present Data at Alzheimer’s Association

Cortexyme, Inc. (CRTX), today announced that its work to pioneer a novel disease-modifying therapeutic approach to treat a key underlying cause of Alzheimer’s and other degenerative diseases will be discussed in two research abstracts at the Alzheimer’s Association International Conference^® 2019 (AAIC^®). The conference, which is the largest international meeting dedicated to advancing dementia science, will be held July 14-18, 2019 in Los Angeles.

In a Developing Topics poster (P4-663), researchers will detail the rationale for and design of the GAIN trial, the recently initiated Phase 2/3 study of Cortexyme’s lead gingipain inhibitor, COR388, in subjects with mild to moderate Alzheimer’s disease (AD). The GAIN trial is based on growing evidence that points to a key role for Porphyromonas gingivalis, the bacterium most commonly associated with chronic periodontal disease, in the development of AD, based on the identification of the bacteria in the brain of AD patients and its ability to cause neurodegeneration, inflammation, and other pathology associated with Alzheimer’s in animal models.

“We’re in a critical moment for Alzheimer’s drug development, and patients deserve new approaches driven by solid science,” said Casey Lynch, Cortexyme’s chief executive officer, chair, and co-founder. “The researchers at Cortexyme, along with our academic and industry collaborators, look forward to the opportunity to share the latest updates on our work to evaluate the gingipain hypothesis, which represents a wholly new, potentially disease-modifying approach to a disease that affects millions of patients and their families globally.”

A second Developing Topics poster (P4-542) will examine the utility of a speech-based digital biomarker for tracking disease progression and treatment response to COR388. This tool, developed by Winterlight Labs, was deployed in Cortexyme’s Phase 1b clinical trial of COR388 and is also being used as an exploratory endpoint in the GAIN trial.

https://finance.yahoo.com/news/cortexyme-announces-upcoming-data-presentations-120000767.html