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Thursday, January 9, 2020

FDA OKs Blueprint kinase inhibitor for GI tumor

The FDA approves Blueprint Medicines’ (BPMC +0.9%) Ayvakit (avapritinib) for the treatment of adults with unresectable/metastatic gastrointestinal stromal tumor (GIST) harboring a platelet-derived growth factor receptor alpha ((PDGFRA)) exon 18 mutation, including PDGFRA D842V-positive GIST, the most common exon 18 mutation.
Avapritinib is an oral inhibitor of KIT- and PDGFRA-mutant kinases which are highly active in GIST.

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