Axon Neuroscience Eyes Promising Peptide Vaccine Against COVID-19

AXON Neuroscience (“Axon”), a clinical-stage biotech company and an industry leader in treating and preventing neurodegenerative diseases, is developing a promising vaccine candidate against COVID-19.

Axon has over 20 years’ experience in development of safe and immunogenic peptide vaccines. Its well-established scalable technology allowed the company to move quickly in recent weeks to create a novel peptide vaccine in support of the global fight against COVID-19.
Norbert Žilka, Chief Scientific Officer of Axon, said: “We have over sixty scientists with expertise in key disciplines – immunology, pharmacology, structural biology, proteomics, genomics – making Axon ideally placed to deliver a rapid solution for combatting the new coronavirus.”
Axon used its established peptide-based vaccine platform to produce a novel prophylactic COVID-19 vaccine, intended to treat infected patients and protect healthy individuals from infection. Axon’s vaccine contains only selected epitopes capable of inducing desirable T cell and B cell mediated immune responses to prevent interaction of the virus Spike (S) glycoprotein with its target human cells, thus preventing the virus from entering the cells and spreading. This approach is designed to prevent the unwanted serious side effects observed in previous studies of conventional vaccines against SARS-CoV.
The elderly patients most at risk for COVID-19 are prone to develop serious respiratory complications and pneumonia, which might result in permanent lung damage or even death. In general, elderly individuals typically do not respond as well to vaccination, resulting in ordinary vaccinations having a limited effect. Axon has developed innovative proprietary technologies to stimulate the immune systems of elderly people and people with immunodeficiencies in order to produce a high antibody response in these vulnerable populations.
“The human immune system slowly deteriorates with age. This immunosenescence, combined with other comorbidities, makes elderly people highly sensitive to SARS-CoV-2 infections and prone to severe respiratory complications. We believe we have a safe and effective vaccine concept to prevent future outbreaks of COVID-19 and at the same time protect the most vulnerable groups,” said Professor Eva Kontsekova, Immunologist and the Head of Immunotherapy at Axon.
The recent workshop co-chaired by both the European Medicines Agency (EMA) and Food and Drug Administration (FDA) confirmed that an expedited regulatory pathway could be available for well-tested vaccine platforms, such as Axon’s. Data from Axon’s previous Alzheimer’s Disease clinical trials could facilitate a quick move to first-in-human clinical trials with the new COVID-19 vaccine.
Peptide vaccines represent a promising alternative to conventional vaccine approaches, particularly given their speed of development and ease of production. Axon’s longstanding strategic collaboration with the European-based global leader in peptide vaccine manufacturing means that the transfer to GMP production is quick, inexpensive and highly scalable due to the established analytical and manufacturing methods used in Axon’s other development programs.
https://www.biospace.com/article/releases/axon-neuroscience-has-a-promising-peptide-vaccine-against-covid-19-in-development/