Abstract
Viral infections are dangerous diseases for human health worldwide, which lead to significant morbidity and mortality each year. Because of their importance and the lack of effective therapeutic approaches, further attempts should be made to discover appropriate alternative or complementary treatments. Melatonin, a multifunctional neurohormone mainly synthesized and secreted by the pineal gland, plays some roles in the treatment of viral infections. Regarding a deadly outbreak of COVID-19 across the world, we decided to discuss melatonin functions against various viral infections including COVID-19. Therefore, in this review, we summarize current evidence on melatonin therapy for viral infections with focus on possible underlying mechanisms of melatonin actions.
Conclusion
This study has provided a comprehensive overview of numerous beneficial properties of melatonin in different viral complications even viral respiratory disorders associated with oxidative stress, inflammation, and immune dysfunction. Literature evidence supports that the management of oxidative stress and inflammatory responses, as well as the regulation of immune responses may be critical to target respiratory virus infections such as SARS-CoV-2. Due to a positive correlation between immune dysfunction and disease severity in patients with COVID-19, it is necessary to consider this condition for preparing the optimal vaccine. The safety of melatonin profile has been broadly examined in different preclinical and clinical studies on wide-range doses. Because of the lack of an available vaccine or effective antiviral treatment for COVID-19, the use of melatonin as an adjuvant might be worth consideration. Although the direct protective action of melatonin against COVID-19 is unknown, its extensive application in animal studies and human clinical trials has repeatedly verified its efficacy and safety in a broad range of disorders. Therefore, melatonin practical usage in the current COVID-19 outbreak is suggested to be beneficial.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405774/
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.