Zinc and COVID-19: Basis of Current Clinical Trials

• Amit Pal,
• Rosanna Squitti,
• Mario Picozza,
• Anil Pawar,
• Mauro Rongioletti,
• Atanu Kumar Dutta,
• Sibasish Sahoo,
• Kalyan Goswami,
• Praveen Sharma &
Rajendra Prasad

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• Biological Trace Element Research (2020)

PDF: https://link.springer.com/content/pdf/10.1007/s12011-020-02437-9.pdf

Abstract

Coronavirus disease-2019 (COVID-19) pandemic continues to threaten patients, societies, and economic and healthcare systems around the world. Like many other diseases, the host immune system determines the progress of COVID-19 and fatality. Modulation of inflammatory response and cytokine production using immunonutrition is a novel concept that has been applied to other diseases as well. Zinc, one of the anti-inflammatory and antioxidant micronutrient found in food with well-established role in immunity, is currently being used in some clinical trials against COVID-19. This review integrates the contemporary studies of role of zinc in antiviral immunity along with discussing its potential role against COVID-19, and ongoing COVID-19 clinical trials using zinc.

https://link.springer.com/article/10.1007/s12011-020-02437-9