Cutaneous Reactions Reported after Moderna and Pfizer COVID-19 Vaccination

 

• DDevon E. McMahon, BA
• Erin Amerson, MD
• Misha Rosenbach, MD
• Kimberly Blumenthal, MD MSc
• Lindy P. Fox, MD
• Esther E. Freeman, MD PhD 
• SDOI:
  https://doi.org/10.1016/j.jaad.2021.03.092
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• Abstract

  Background

  Cutaneous reactions after mRNA-based COVID-19 vaccines have been reported but are not well characterized.

  Objective

  To evaluate morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

  Methods

  A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination.

  Results

  From December 2020-February 2021, we recorded 414 cutaneous reactions to mRNA COVID-19 vaccines from Moderna (83%) and Pfizer (17%). Delayed large local reactions were most common, followed by local injection site reactions, urticarial eruptions, and morbilliform eruptions. Forty-three percent of patients with first dose reactions experienced second dose recurrence.

  Limitations

  Registry analysis does not measure incidence. Morphologic misclassification is possible.

  Conclusion

  We report a spectrum of cutaneous reactions after COVID-19 mRNA vaccines. Most patients with first dose reactions did not develop a second dose reaction, and no patients in the registry developed serious adverse events after the first or second dose. These data provide reassurance to patients and providers.
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• https://www.jaad.org/article/S0190-9622(21)00658-7/fulltext
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