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Wednesday, April 28, 2021

Flexion: Positive prelim data on knee osteoarthritis

 

  • Findings from a Phase 1 single ascending dose trial indicate the low dose of FX201, an intra-articular gene therapy candidate for osteoarthritis (OA), was generally well-tolerated

  • Two of five patients (40%) treated with FX201 in the low-dose, single ascending dose cohort reported substantial improvement in pain out to Week 24

  • No evidence of systemic biodistribution of FX201 in plasma or shedding in urine or at the injection site was observed in any patient

  • Longer term follow-up data from the low-dose cohort will be presented at ASGCT on May 11

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