SARS-CoV-2 exposure generates T-cell memory in absence of detectable viral infection

 

Zhongfang Wang, 

Xiaoyun Yang, 

Jiaying Zhong, 

Yumin Zhou, 

Zhiqiang Tang, 

Haibo Zhou, 

Jun He, 

Xinyue Mei, 

Yonghong Tang, 

Bijia Lin, 

Zhenjun Chen, 

James McCluskey, 

Ji Yang,

Alexandra J. Corbett & 

Pixin Ran

PDF: https://www.nature.com/articles/s41467-021-22036-z.pdf

Abstract

T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. We also demonstrate the size and quality of the memory T-cell pool of COVID-19 patients are larger and better than those of close contacts. However, the proliferation capacity, size and quality of T-cell responses in close contacts are readily distinguishable from healthy donors, suggesting close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection. Additionally, asymptomatic and symptomatic COVID-19 patients contain similar levels of SARS-CoV-2-specific T-cell memory. Overall, this study demonstrates the versatility and potential of memory T cells from COVID-19 patients and close contacts, which may be important for host protection.

https://www.nature.com/articles/s41467-021-22036-z