Obstructive sleep apnea highly prevalent in COVID19 moderate to severe ARDS survivors

 Abhishek Goyal, Khushboo Saxena, Avishek Kar, Alkesh Khurana, Abhijit P Pakhare, Parneet Kaur Bhagtana, Chinta Siva Koti Rupa Sridevi

doi: https://doi.org/10.1101/2021.05.04.21256593

This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

PDF: https://www.medrxiv.org/content/10.1101/2021.05.04.21256593v1.full.pdf

Abstract

Study Objectives- Studies have found Obstructive Sleep Apnea (OSA) as a risk factor for increased risk for COVID19 Acute respiratory Distress Syndrome (ARDS); but most of the studies were done in already known patients of OSA. This study was done to find prevalence of OSA in patients with COVID-19 related acute respiratory distress syndrome. Methodology- A hospital based longitudinal study was conducted among COVID 19 Intensive Care Unit (ICU) survivors. All consecutive COVID19 with moderate to severe ARDS were evaluated for OSA by Level I Polysomnography (PSG) after 4-6 weeks of discharge. Prevalence of OSA and PSG variables {Total sleep time, Sleep efficiency, sleep stage percentage, Apnea Hypopnea Index (AHI), T90, nadir oxygen} was estimated. Results- Out of 103 patients discharged from ICU during study period (October 2020 to 15 December 2020), 67 underwent Level I PSG. Mean Age was 52.6 years and mean Body Mass Index was 27.5 Kg/m2. Total sleep time was 343.2 minutes, sleep efficiency was 75.9. OSA (AHI more than 5 ) was seen in 65/67 patients and 49 patients had moderate to severe OSA (i.e. AHI more than 15). Conclusion- Moderate-severe OSA was highly prevalent (73%) in COVID19 moderate to severe ARDS survivors. Role of OSA in pathophysiology of COVID19 ARDS needs further evaluation.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

This was a non funded study

https://www.medrxiv.org/content/10.1101/2021.05.04.21256593v1