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Saturday, May 8, 2021

Unexpected tumor reduction in metastatic colorectal cancer during SARS-Cov-2 infection

 



PDF: https://scholar.google.com/scholar_url?url=https://journals.sagepub.com/doi/pdf/10.1177/17588359211011455&hl=en&sa=T&oi=ucasa&ct=ufr&ei=d5mWYKS2Do3nmQGH3ofYDQ&scisig=AAGBfm2hgZVKofqNEcOI2qE8SLrwIBZTQA

Herein, we describe three patients affected by metastatic colorectal cancer (mCRC) experiencing infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) and reduction of disease burden during coronavirus disease 2019 (COVID-19) course. Insights into tumor-associated angiotensin-converting enzyme (ACE)-2 expression and lymphocyte function suggest a correlation between host/SARS-Cov-2 infection and tumor burden reduction. This may shed new light into (a) the infection mechanism of SARS-CoV-2 virus and (b) the multiple aspects of a composite antiviral immune response with potential paradoxical and unexpected applications.

https://journals.sagepub.com/doi/full/10.1177/17588359211011455

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