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Friday, June 11, 2021

AbbVie: 4-year Phase 3 Venetoclax Trial Followup Continues Longer Leukemia Survival

  AbbVie (ABBV) announced Friday results from a four-year follow-up analysis of the Phase 3 CLL14 trial. The new data shows that AbbVie's VENCLYXTO/VENCLEXTA fixed duration combination demonstrates sustained progression-free survival or PFS in chronic lymphocytic leukemia or CLL patients after three years off treatment.

CLL is a slow-growing form of leukemia, or blood cancer, in which too many immature lymphocytes are found predominantly in the blood and bone marrow.

The data showed that previously untreated patients with CLL with coexisting conditions who were treated with VENCLYXTO/VENCLEXTA (venetoclax) plus obinutuzumab continued to show longer PFS and higher rates of undetectable minimal residual disease or MRD compared to patients receiving a standard of care chemoimmunotherapy regimen of obinutuzumab and chlorambucil.

The data were presented for the first time during the virtual 26th European Hematology Association Annual Congress.

https://www.nasdaq.com/articles/abbvie%3A-4-year-follow-up-analysis-of-phase-3-venetoclax-trial-continues-to-show-longer-pfs

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