Synaptogenix Discloses Further Bryostatin Trial Analyses at Alzheimer's Association

 Synaptogenix, Inc. (Nasdaq: SNPX), an emerging biopharmaceutical company focused on developing therapies for neurodegenerative diseases, today announced that its abstract for presentation at the Alzheimer's Association International Conference (AAIC) is now available entitled "Bryostatin Restores Cognitive Functions Above Baseline in Advanced Alzheimer's Disease (AD) Patients: A Regenerative Therapeutic Strategy."

"Recent further analyses of pre-specified cohort results revealed clear evidence of Bryostatin therapeutic efficacy for advanced AD patients. Analyses of treatment benefit, based on mean differences and as a function of successive dosing in the Company's two previous, separate clinical studies (#202 and #203), used each patient as his / her own control in both treatment and placebo groups. While these separate analyses showed treatment benefit, the combined groups in a pooled analysis conducted here produced a highly significant statistical separation of the Bryostatin treatment group (P<.001) from the placebo group. Consolidation of identically enrolled and treated patients in the two clinical trials increased the power (N = 95) of pre-specified Treatment and Placebo groups with the resulting separation. This integrated data analysis provides further encouragement that Bryostatin can make a clinically meaningful difference for treating the underlying pathology and cognitive deterioration of AD – as is now being tested in an NIH-sponsored, six-month clinical trial, incorporating lessons learned from the two previous pilot studies. This potential efficacy involved significant improvement over baseline (> + 4.0 Severe Impairment Battery, SIB, score), not only reduction in the rate of cognitive decline," commented Dr. Daniel Alkon, President and Chief Scientific Officer.

The abstract can be accessed via the following link: https://www.synaptogen.com/wp-content/uploads/2021/07/ESCIOBAADP.pdf

Also, as previously announced, Synaptogenix will hold a conference call for investors to discuss its abstract. The call will take place, today, Monday, July 26th at 4:15pm ET and will be hosted by the Company's Chief Executive Officer, Dr. Alan Tuchman, and its President and Chief Science Officer, Dr. Daniel Alkon. Drs. Tuchman and Alkon will take live Q&A following their prepared remarks.

The U.S. toll free dial-in for the conference call is (877) 407-9205, and the international dial-in number is 1-(201)-689-8054. A live webcast of the conference call will also be available via: https://www.webcaster4.com/Webcast/Page/2599/42216.

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