Precision BioSciences Inc (NASDAQ: DTIL) and iECURE announced a license and collaboration agreement.
Under the agreement iECURE plans to advance Precision's PBGENE-PCSK9 candidate into Phase 1 studies and gain access to Precision's PCSK9-directed ARCUS nuclease to develop additional gene-editing therapies for genetic diseases, initially targeting liver diseases.
iECURE plans to file a clinical trial application in 2022 to advance the PBGENE-PCSK9 through Phase 1 studies for familial hypercholesterolemia (FH).
Precision will retain rights to PBGENE-PCSK9.
In return, Precision has granted iECURE a license to use its PCSK9-directed ARCUS nuclease to insert genes into the well-characterized PCSK9 locus to develop treatments for four other pre-specified rare genetic diseases.
Precision will receive an equity stake in iECURE and is eligible to receive milestone and royalty payments.
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