Gritstone: Results from Preclinical Study of Self-amplifying mRNA covid vax

 - Results, which were previously pre-printed in bioRxiv, show Gritstone’s second-generation self-amplifying mRNA (samRNA) vaccine candidate drove broad neutralizing antibodies, T cell responses and offered protection against SARS-CoV-2 infection in rhesus macaques --

-- Neutralizing antibody responses were induced at up to a 10-fold lower dose than first-generation mRNA vaccines --

-- Durable protection against SARS-CoV-2 in rhesus macaques observed with the samRNA vaccine regimen supports ongoing therapeutic exploration in coronaviruses and other infectious diseases --

https://www.biospace.com/article/releases/gritstone-announces-results-from-preclinical-study-of-its-self-amplifying-mrna-samrna-vaccine-against-sars-cov-2-published-in-nature-communications/