Aridis Pan-Coronavirus, Inhaled Antibody Cocktail Protective in Non-Human Primates

  Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS), a biopharmaceutical company focused on the discovery and development of novel anti-infective therapies to treat life-threatening infections, announced today that inhaled treatment of its fully human monoclonal antibody cocktail AR-701 resulted in no detectable SARS-CoV-2 virus in the lungs of infected rhesus macaques, and protected their lungs from disease. AR-701 was effective in the non-human primates when used either as a prophylactic or therapeutic treatment regimen.

• Therapeutic administration of inhaled AR-701 substantially reduced and continued to suppress the viral load in the nasal sinus and oropharynx (upper respiratory tract region) for the entire 5-day testing period.
• Additional lab research also indicates both mAbs in the AR-701 cocktail are effective against the SARS-CoV-2 Omicron BA.1, BA.2, BA.4, BA.5 subvariants in vitro. 

This non-human primate research was conducted through a collective effort involving researchers at the Oregon National Primate Research Center (ONPRC) at Oregon Health & Science University (OHSU), the University of California at Davis, Vanderbilt University, the University of California at Irvine, and Aridis, with a grant supplement to OHSU from the National Institutes of Health's Office of Research Infrastructure Programs in the Office of the Director (OD, PHS grant P51 OD011092).  Preliminary study results were recently presented at the Immunotherapy for Infectious Diseases Conference 2022 in Pavia, Italy. Additional data are being analyzed and will be submitted to a peer-reviewed scientific journal for publication.

https://www.biospace.com/article/releases/aridis-pan-coronavirus-inhaled-monoclonal-antibody-cocktail-ar-701-is-protective-in-non-human-primates/