EyePoint in Phase 2 PAVIA Clinical Trial for Treatment of Non-Proliferative Diabetic Retinopathy

 EyePoint Pharmaceuticals, Inc. (NASDAQ: EYPT), a pharmaceutical company committed to developing and commercializing therapeutics to improve the lives of patients with serious eye disorders, today announced that the first patient has been dosed in the Phase 2 PAVIA clinical trial of EYP-1901, a potential sustained delivery intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment targeting non-proliferative diabetic retinopathy (NPDR).

“We are excited to announce the first patient dosing of the Phase 2 PAVIA clinical trial of EYP-1901 for NPDR, a serious eye disorder affecting almost one-third of adults over the age of 40 with diabetes that can lead to severe vision loss if left uncontrolled,” said Jay Duker, M.D., Chief Operating Officer of EyePoint Pharmaceuticals. “Despite the severe nature of this disease, the current standard-of-care is no treatment until a patient develops sight-threatening complications. There remains a lack of approved treatments for this serious eye disease, leaving a significant opportunity for a long-acting treatment option that maintains the patient’s existing vision proactively. Building on EYP-1901’s excellent safety and efficacy results from our Phase 1 DAVIO trial in wet AMD, we believe that EYP-1901 has the potential to improve the current treatment paradigm as a sustained delivery maintenance treatment for NPDR and significantly improve the lives of patients living with this serious eye disorder.”

The 12-month, randomized, controlled Phase 2 PAVIA clinical trial of EYP-1901 for NPDR is expected to enroll approximately 105 patients randomly assigned to one of two doses of EYP-1901 (approximately 2 mg or 3 mg), or to the control group receiving a sham injection. EYP-1901 is delivered with a single intravitreal injection in the physician's office. The primary efficacy endpoint of the trial is improvement of at least two diabetic retinopathy severity scale (DRSS) severity levels as of week 36 after the EYP-1901 injection. Secondary endpoints include vision-threatening complications, occurrence of DME and/or proliferative disease, retinal ischemia/nonperfusion and safety. More information about the study is available at clinicaltrials.gov (identifier: NCT05383209).

https://www.biospace.com/article/releases/eyepoint-pharmaceuticals-announces-first-patient-dosed-in-phase-2-pavia-clinical-trial-of-eyp-1901-for-the-treatment-of-non-proliferative-diabetic-retinopathy/