CinCor Topline Data for Phase 2 Hypertension Trial Misses

 Primary endpoint in Intention to Treat (ITT) was not met despite large absolute reductions in Systolic Blood Pressure (SBP)

12.6 mmHg placebo-adjusted reduction in SBP with 2 mg baxdrostat in a pre-specified subgroup that represents approximately 81-89% of the U.S. hypertension population (nominal p-value = 0.001)

Safety profile and tolerability consistent with BrigHtn Phase 2 data; no patient discontinued due to treatment-related adverse events; low hyperkalemia incidence

HALO in combination with BrigHtn informs the dose and study populations anticipated to be recruited into Phase 3 trials pending confirmation by FDA at planned end of Phase 2 meeting in January 2023; Phase 3 trials expected to begin first half of 2023

Baxdrostat’s clinical program remains on track for a potential NDA submission in 2025

Conference call and live webcast today at 8:00 AM Eastern Time

CinCor management will hold a conference call and live webcast today at 8:00 AM Eastern Time to provide an update on the Phase 2 HALO trial. The dial-in number for the conference call is 877-407-9039 (U.S./Canada) or 201-689-8470 (international). The conference ID for all callers is 13734665. The live webcast and replay may be accessed by visiting the CinCor website at https://www.cincor.com/events-presentations. The replay will be available for 30 days following the call.

https://finance.yahoo.com/news/cincor-pharma-announces-topline-data-123000488.html