Cognition Therapeutics Highlights Phase 2 Dementia Study

 Innovative trial addresses second most common dementia after Alzheimer’s disease, now enrolling patients at up to 30 activated sites across the USA

 Cognition Therapeutics, Inc., (Nasdaq: CGTX), (the “Company” or “Cognition”), today announced that the rationale and design of the Company’s ongoing SHIMMER clinical trial of CT1812 will be presented at the 2022 Clinical Trials in Alzheimer’s Disease (CTAD) conference. The Phase 2 SHIMMER (COG1201) study is intended to assess the safety, tolerability, and efficacy of CT1812 in individuals with dementia with Lewy bodies (DLB). CT1812 is a novel oral, once-daily small-molecule therapeutic designed to protect neurons from pathogenic forms of proteins such as α-synuclein and beta amyloid (Aβ) by preventing oligomers from binding to synapses.

There are currently no approved treatments for DLB, which impacts an estimated 1.4 million people in the United States, making it the second most common form of dementia. Patients may present with symptoms including cognitive or motor deficits, or changes in behavior (sleep disorders, hallucinations, anxiety), which can masquerade as other conditions, making it challenging to correctly diagnose DLB. It is believed that aggregated forms of α-synuclein and Aβ bind to neurons, triggering failures in protein trafficking and other key cellular functions. Such a catastrophic failure in cellular function eventually leads to the loss of neurons, driving disease pathology and giving rise to the constellation of symptoms associated with DLB.

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