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Thursday, January 26, 2023

AC Immune Alzheimer's Vaccine Shows Positive Initial Interim Safety, Immunogenicity in Phase 1b/2

 AC Immune’s ACI-24.060 Anti-Amyloid Beta Vaccine for Alzheimer’s Shows Positive Initial Interim Safety and Immunogenicity in Phase 1b/2 ABATE Trial

  • ACI-24.060 elicited an anti-Abeta antibody response in ABATE’s first, low dose cohort

  • ACI-24.060 was generally well tolerated with no safety concerns observed

  • With these findings, dosing in the second, higher dose Alzheimer’s cohort has begun

  • Screening of cohort of study participants with Down syndrome also cleared to begin

  • Further safety and immunogenicity findings from ABATE cohorts expected in H2 2023

  • Initial data on amyloid plaque reduction measured via PET imaging anticipated in 2024

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