Arcutis: New Phase 2 Data in Adults with Chronic Plaque Psoriasis

 

• During the open label trial, 57.1% of roflumilast-treated participants achieved Investigator Global Assessment (IGA) of clear or almost clear at any time in study; the median duration of clear or almost clear was 10 months (40.1 weeks)
• Efficacy was consistent over time across all endpoints, and no lessening of response (no tachyphylaxis) from roflumilast cream was observed
• Long-term IGA success and Intertriginous-Investigator Global Assessment (I-IGA) success results are consistent with results from the DERMIS-1 and DERMIS-2 Phase 3 clinical trials
• Roflumilast cream was very well-tolerated, with low rates of discontinuations due to either adverse events or lack of efficacy

https://www.biospace.com/article/releases/arcutis-presents-new-phase-2-long-term-data-showing-sustained-efficacy-and-clearance-for-a-median-of-10-months-with-roflumilast-cream-in-adults-with-chronic-plaque-psoriasis/