aTyr: Preclinical data on aggressive cancer inhibitory treatment at AACR

  aTyr Pharma Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, today announced a poster presentation at the 2023 American Association for Cancer Research (AACR) Annual Meeting, which is being held April 14 – 19, 2023, in Orlando, FL. The abstract is available on the AACR website. The poster will be available on the aTyr website once presented.

The poster presents preclinical findings characterizing the inhibition of tumor growth and therapy resistance in aggressive cancers overexpressing VEGF-C treated with ATYR2810, a fully humanized monoclonal antibody that selectively and functionally blocks neuropilin-2 (NRP2) and VEGF-C signaling by directly binding at the site of the VEGF binding pocket. Treatment with ATYR2810 monotherapy and in combination with chemotherapy in a model of non-small cell lung cancer demonstrated increased tumor growth inhibition and sensitivity to chemotherapy. In a model of clear cell renal cell carcinoma, ATYR2810 in combination with the VEGFR-targeted therapy sunitinib inhibited tumor growth and led to tumor regression in some cases. These data demonstrate the potential therapeutic effects of blocking the NRP2/VEGF-C signaling axis with ATYR2810 on enhanced tumor growth inhibition and sensitivity to chemotherapy and targeted therapy.

https://www.biospace.com/article/releases/atyr-pharma-presents-preclinical-research-demonstrating-treatment-with-atyr2810-inhibits-tumor-growth-and-therapy-resistance-in-highly-aggressive-cancers-at-the-2023-aacr-annual-meeting-/