'Pasithea Positive Initial Results in Phase 1 Clinical Trial of PAS-004 in Advanced Cancer'

 -- Single patient in 2mg cohort with stage 3 colon cancer who received 4 prior lines of therapy achieves prolonged stable disease and remains on drug into 6th dosing cycle --

-- No treatment-related adverse events (TRAEs) or dose-limiting toxicities (DLTs) observed to date, including no rash or gastrointestinal (GI) AEs --

-- Systemic exposure at steady-state enables constant target inhibition while avoiding peak plasma toxicities --

-- Half-life of approximately 70 hours supports once-daily or less frequent oral dosing --

-- Distinctive MEK inhibitor profile for the treatment of both NF1-related plexiform and cutaneous neurofibromas, cancer, and other opportunities --

https://www.globenewswire.com/news-release/2024/09/26/2953686/0/en/Pasithea-Therapeutics-Announces-Positive-Initial-Safety-Tolerability-Pharmacokinetic-PK-and-Preliminary-Efficacy-Data-from-its-Phase-1-Clinical-Trial-of-PAS-004-in-Advanced-Cancer.html