Sana Positive Results in Type 1 Diabetes Study of Islet Cell Transplant Without Immunosuppression

 First-in-Human Study Provides Evidence that Sana’s Hypoimmune (HIP) Technology Enables Transplanted Islet Cells to Avoid Immune Rejection and Produce Insulin Without Immunosuppression

Results Demonstrate HIP-Engineered Primary Pancreatic Islet Cells Avoid Immune Detection, Function, and Persist after Intramuscular Transplantation in First Treated Patient with Type 1 Diabetes

Function and Persistence of Pancreatic Islets Were Detectable by Production of Consistent Levels of Circulating C-Peptide, a Marker of Insulin Production, and Increased C-Peptide Levels with a Mixed Meal Tolerance Test (MMTT)

MRI Shows Signals Consistent with Graft Survival 28 Days after Transplantation

Study Continues to Evaluate Safety, Persistence, and Function of Transplanted Cells

Conference Call to be Webcast at 1:30pm PT

Sana will host a webcast conference call to discuss results today, January 7, 2025 at 1:30 p.m. PT. The live webcast and audio archive of the presentation will be accessible on the Investor Relations page of Sana’s website at https://sana.com/. The call can be accessed by dialing (877)-346-6112 (domestic) or (848)-280-6350 (international) and referring to conference ID 9582416.

https://www.globenewswire.com/news-release/2025/01/07/3005841/0/en/Sana-Biotechnology-Announces-Positive-Clinical-Results-from-Type-1-Diabetes-Study-of-Islet-Cell-Transplantation-Without-Immunosuppression.html