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Friday, August 17, 2018

Hospital Readmissions Drop for Stroke Patients


The 30-day hospital readmission rate for stroke patients declined by an annual average of 3.3% from 2010 to 2014, national data on more than 2 million stroke hospital discharges indicated.
About one in eight adult stroke patients were readmitted within 30 days of hospital discharge in that period, but stroke patients discharged from high-volume non-teaching hospitals were more likely to return than patients treated at high-volume academic centers, reported Farhaan Vahidy, MD, MPH, PhD, of McGovern Medical School at UTHealth in Houston, and colleagues in JAMA Network Open.
“This work provides the most comprehensive evidence to date that 30-day readmission rates have declined during 2010 to 2014 in the U.S. for patients with different types of stroke — ischemic stroke, primary intracerebral hemorrhage, and subarachnoid hemorrhage,” Vahidy told MedPage Today.
Reducing ischemic stroke readmissions is a quality metric of the Centers for Medicare & Medicaid Services (CMS), but less is known about readmission rates of stroke patients who are covered by other insurers or uninsured, or people who have hemorrhagic strokes.
In the current study, Vahidy and colleagues analyzed 2,078,854 index stroke events in the Nationwide Readmissions Database of the Healthcare Cost and Utilization Project between January 1, 2010, and September 30, 2015, representing 50% of all U.S. hospitalizations in 22 states. Of these events, 87.6% were acute ischemic strokes, 8.7% were intracerebral hemorrhages, and 3.6% were subarachnoid hemorrhages. The researchers defined readmission as any admission within 30 days of index hospitalization discharge.
Mean patient age was about 70 and 51.9% were female. More than 35% of patients in the study were younger than 65, and more than 25% were not insured by Medicare or Medicaid.
Overall, 13.7% of intracerebral hemorrhage patients, 12.4% of acute ischemic stroke patients, and 11.5% of subarachnoid hemorrhage patients were readmitted within 30 days.
About one in five readmissions had the same primary discharge diagnosis as the index hospitalization; the second most common readmission reason was septicemia. Based on CMS-defined algorithms, more than 90% of readmissions were unplanned; depending on the stroke subtype, up to 13.6% were considered potentially preventable.
Among patients with acute ischemic stroke, 30-day readmission rates were significantly lower for patients younger than age 65 compared with older patients (10.8% versus 13.3%). There also were significant differences in readmission rates between payer types (OR 0.70 for private insurance versus Medicare), even after controlling for age, suggesting CMS readmission estimates may not be nationally representative.
While teaching hospitals had steady readmission rates on average regardless of how many stroke cases they treated, non-academic centers had higher readmission rates with increasing numbers of stroke patients.
“Intuitively, you would think that the higher volume of stroke patients a hospital treats, the better the quality of care is and the better their outcomes,” observed Adam Webb, MD, of Emory University Hospital in Atlanta, who was not involved in the study. “In fact, this is just the opposite for readmission in non-teaching hospitals.”
“The authors correctly point out that high-volume teaching hospitals are more likely to participate in stroke quality data registries such as Get With The Guidelines and may be more likely to be Joint Commission–accredited stroke centers,” Webb told MedPage Today.“This is yet another argument why stroke systems of care should be set up, whenever possible, to route patients to these types of hospitals.”
This research “provides a nationally representative benchmark to examine readmission rates for patients hospitalized with stroke,” added Elan Guterman, MD, of the University of California San Francisco, who also was not involved with the study.
“It also demonstrates clear variation in readmission rate across different institutional settings and over time,” Guterman said. “This is an informative place to start and poses many important questions about what is driving this variability.”
The analysis has several limitations, the researchers noted; for example, the database did not allow them to control for stroke-specific severity measures or track individual patients across multiple years.
The findings are best suited for improving local care rather than establishing a national performance standard, they added: “Further work is warranted to establish the validity of national readmission measures, particularly in the context of emerging evidence of compromised survival associated with readmission reduction for other conditions.”
The authors declared no competing interests.

Robot-powered digital pharmacy to open in UK


A robot-powered digital pharmacy is to open in Liverpool, aimed at helping people with chronic conditions get medicines delivered for free using the AI mobile app, Now Patient.
The £1.5m project will create around 30 jobs in the city, which has been highlighted as having some of the most deprived health districts in the UK.
The pharmacy run by Now Patient, developed by Now Healthcare Group, will be able to dispense around 500,000 prescriptions per month using the latest robotic distribution technology.
The NHS-approved telepharmacy “super-hub” aims to revolutionise services for those who have suffered through recent community pharmacy cuts and have difficulty accessing their medications.
The Now Patient app was created to enable up to 15 million people living with long-term health conditions such as cancer, diabetes and lung disease, to get free delivery of their repeat NHS prescriptions across Liverpool – and the rest of the UK.
The robot used in Liverpool is the latest specification and speeds up the dispensing process by selecting the correct products via box size, not name or label.
NHS chronic care patients can nominate Now Patient as their NHS pharmacy to get free delivery of their repeat prescriptions nationwide.
Now Healthcare Group has agreed a contract with the NHS to ensure they deliver the same quality service for the whole of England. The app is free to download and available on iOS and Android.
There has been a huge demise in high street pharmacies – since January 2017, pharmacy chain Lloyds has shut and sold off more than 190 branches amid cuts in funding from the government.
Figures uncovered earlier this year by the website Chemist and Druggist showed that 156 pharmacies have closed between April 2016 and April 2018.
The government’s plan cut funding by 4% in 2016-17 and 3.4% in 2017-18, when the pharmacy budget was £2.592 billion.
Now Healthcare Group was founded by Lee Dentith who established the business when he could not get a GP appointment for his son.
As a result he set about creating technology to enable GP appointments from mobile phones, which is one of the company’s offerings.
Lee Dentith, founder and CEO of Now Healthcare Group said: “The NHS is evolving, and digital innovation is crucial to offering patients quality care and choice. 15 million people in the UK are suffering with chronic conditions, and Now Patient enables them to be empowered to manage their own healthcare needs and to reduce the strain on our country’s overstretched health services.”

Avista Healthcare Public Acquisition Corp., Organogenesis set combination


Avista Healthcare Public Acquisition Corp and Organogenesis announced that they have entered into a definitive merger agreement, under which Organogenesis will become a wholly owned subsidiary of AHPAC. Affiliates of Avista Capital Partners have agreed to invest $92M in the combined company in conjunction with the transaction. Following the closing of the transaction, Organogenesis will be listed on the Nasdaq Stock Exchange under the ticker symbol (ORGO) The combined company will have an anticipated initial enterprise value of approximately $673M. Organogenesis’ mission is to provide integrated healing solutions that improve medical outcomes and the lives of patients, while lowering the overall cost of care. Organogenesis’ product portfolio is designed to treat a variety of patients with repair and regenerative needs across the continuum of care. Organogenesis has over 600 employees worldwide and is led by a management team of with more than 75 years of collective regenerative medicine experience. This transaction will be funded through a combination of cash, stock, and rollover debt financing. Organogenesis’ key existing shareholders will remain committed long-term partners by rolling over their equity into the combined company. The boards of directors of AHPAC and the company have unanimously approved the proposed transaction and shareholders of the company representing approximately 89% of the outstanding stock of the company have agreed to support approval of the proposed transaction in any consent solicitation or shareholders’ meeting in connection with the transaction. Completion of the proposed transaction, which is expected before the end of the year, is subject to customary and other closing conditions, including regulatory approvals and receipt of approvals from AHPAC’s shareholders.

Alpine Immune Sciences (ALPN) Now Covered by Raymond James


Raymond James initiated coverage on shares of Alpine Immune Sciences (NASDAQ:ALPN) in a report issued on Monday, The Fly reports. The brokerage set a “buy” rating and a $13.00 price target on the biotechnology company’s stock. Raymond James’ price target indicates a potential upside of 89.78% from the company’s previous close.

Cipla Approved for Generic Reyataz Antiretroviral


Cipla Limited (‘Cipla’) today announced that it has received final approval for its Abbreviated New Drug Application (ANDA) for Atazanavir Caps 100mg, 150mg, 200mg, 300mg from the United States Food and Drug Administration (US FDA).
Cipla’s Atazanavir Caps 100mg, 150mg, 200mg, 300mg is AB-rated generic therapeutic equivalent version of Bristol-Myers Squibb Pharma Company’s, Reyataz. It is a protease inhibitor indicated for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in patients with minimum age of 6 years and older weighing at least 15 kg.
According to IQVIA (IMS Health), Reyataz and its generic equivalents had US sales of approximately $324M for the 12-month period ending April 2018.

Shionogi New Drug Application in Japan for Treatment of Adult ADHD


Shionogi & Co., Ltd. (hereafter ‘Shionogi’) today announced that Shionogi applied for approval to manufacture and sell the therapeutic agent for adult indication of attention deficit hyperactivity disorder (ADHD), INTUNIV Tablets 1mg/3mg (generic name: guanfacine hydrochloride).
Shionogi & Shire conducted the clinical studies of INTUNIV in adult ADHD patients (18 years old and over) in Japan first in the world. INTUNIV demonstrated a statistically significant improvement compared with placebo in the primary endpoint of ADHD evaluation scale. INTUNIV also demonstrated statistically significant superior efficacy compared with placebo in the clinically important secondary endpoint of the clinical global impression improvement scale (CGI-I). Additionally, INTUNIV demonstrated favorable safety and efficacy profile in long-term treatment for 1 year at longest.
INTUNIV is a ‘selective 2A adrenergic receptor agonist’, firstly approved as a drug for ADHD with this mechanism of action, and INTUNIV is a non-central nervous system stimulant that is to be administered once daily and has been approved as a drug for ADHD in pediatric patients (6 to 17 years old) in 36 countries including Japan. In Japan, Shionogi launched INTUNIV for indication of ADHD in pediatric patients on May 2017. Shionogi will further contribute to treatment of ADHD through providing INTUNIV as a new treatment option for adult ADHD patients.

Glenmark eyes collaboration for India orthopaedic, pain management business


Glenmark Pharmaceuticals Ltd, a research-led global integrated pharmaceutical company, today announced that it has entered into a collaboration with leading, home-grown private equity firm True North for its orthopaedic and pain management business for India and Nepal market.
Under this collaboration, Glenmark’s orthopaedic and pain management business, valued at Rs. 635 cr., will be transferred to a new entity to-be incorporated by True North. New entity would be named as ‘Integrace Private Limited’ or any such other name including the name ‘Integrace’ as may be approved by Central Registration Centre (‘Integrace’). Integrace will market the product portfolio in India and Nepal. The transaction is expected to be completed in 2-3 months.
Sujesh Vasudevan, President India Formulations, Middle East and Africa at Glenmarkwill join the Board of Directors of Integrace.
Glenmark is one of the fastest growing companies in the Indian pharmaceutical market. The company’s orthopaedic and pain management business in India, consisting of brands such as Esoz, Bon K2, Collasmart, and Lizolid, clocked revenue of Rs.155.8 cr. in FY 2017-18. Glenmark’s orthopaedic and pain management business accounted for 6% of the company’s India sales and 1.7% of the total consolidated revenue in FY 2017-18. The key brands are leaders in their respective therapy areas.
‘Glenmark is present in multiple therapy areas in India and remains committed to grow each of the business segments. With a view to provide additional focus and resources to the orthopaedic franchise, we are collaborating with True North and firmly believe that this alliance will help unleash the full potential of this business,’ said Sujesh Vasudevan, President India Formulations, Middle East and Africa at Glenmark.
True North (formerly known as India Value Fund), has USD 2.5 billion of assets under management and has invested in more than 30 companies in its 19 years of operations.