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Thursday, December 6, 2018

China’s WuXi AppTec raises $1 billion in Hong Kong listing


Chinese medical tech platform WuXi AppTec raised $1.01 billion in its Hong Kong listing, sources told Reuters on Friday, making it one of this year’s last big deals in the Asian financial hub to end on a positive note.

Shanghai-listed WuXi priced its listing at HK$68 ($8.71) per share, at the middle of an indicated range of HK$64.1-HK$71.5, said the sources, who are familiar with the matter.
It could raise up to $1.16 billion if an over-allotment option is exercised within a month of the start of trading.
WuXi could not be immediately reached for a comment.
This listing should come as good news for Hong Kong where many firms like Meituan Dianping have sunk below their IPO prices, while others have scaled back their targeted fundraising amid jittery markets.
Bankers have been hoping for WuXi and tech giant Tencent’s music arm, which launched its hotly-anticipated U.S. initial public offering (IPO) of up to $1.2 billion on Monday, to go well and help usher in 2019 on a positive note.
One source said WuXi could have priced higher – it was giving guidance of HK$70 on Thursday – but wanted to leave money on the table because of volatile markets this week.
Hong Kong is on track to become the world’s top IPO centre by volume this year, with $33.2 billion raised so far, Refinitiv data shows. But concerns over a China-U.S. trade war and slowing growth in the world’s No.2 economy continue to be a drag.
Hong Kong’s benchmark Hang Seng is down more than 12 percent this year.
Shanghai-based WuXi describes itself as the largest pharmaceutical R&D services platform in Asia by revenue.
The company had revenues of 4.41 billion yuan ($641 million) in the first half of this year, versus 3.67 billion yuan in the same period last year, according to its listing prospectus. Its profits jumped 67 percent to 1.3 billion yuan in the first half.
WuXi intends to use the proceeds from the listing to expand capacity across its units globally, invest in seven China projects such as a Chengdu R&D campus and set up a bioanalytical laboratory in San Diego, California, the prospectus says.
It also intends to fund the acquisition of contract research organisation companies.
WuXi shares will begin trading in Hong Kong on Dec. 13.
Goldman Sachs, Huatai Financial and Morgan Stanley are sponsoring the listing.

Almost Half of Americans to Skip Flu Shot This Year


More than 40% of Americans have not been vaccinated against influenza this year and don’t plan to get vaccinated, despite repeated warnings about the potential dangers of the flu, as well as last year’s record-high number of deaths from flu, a new survey indicates.
The survey included 1202 interviews with a nationally representative sample of adults aged 18 years and older. It was conducted between November 14 and 19 by the National Opinion Research Center (NORC) at the University of Chicago.
Results showed that 43% of adults had received the flu shot and that 14% had not yet been vaccinated but intended to get vaccinated this season. Yet, 41% of adults surveyed said they had not been vaccinated and did not intend to get vaccinated. About 2% were undecided about getting the flu shot or did not respond to the question.
The highest vaccination rate (62%) was for adults older than 60 years, a group at higher risk for flu-related complications. However, 1 in 4 (24%) people aged 60 years and older did not plan to get vaccinated this year.
Adults younger than 45 were the least likely to report being vaccinated. Roughly half of this group indicated that they did not plan to receive a vaccination this year.
Among adults who have children younger than 18 years living in their home, 39% said they do not vaccinate their children.

Misconceptions Common

The top reasons people cited for not getting vaccinated against the flu were concern about side effects from the vaccine (36%), concern about getting the flu from the vaccine (31%), and because they never get the flu or they do not think the flu vaccine works (31%).
“Unfortunately, many people are still not getting flu shots due to broader misconceptions about the value of receiving a flu shot and concerns about the safety and efficacy of the vaccines,” Caitlin Oppenheimer, MPH, senior vice president of public health research at NORC, said in a news release.
The Centers for Disease Control and Prevention (CDC) recommends routine annual influenza vaccination for all persons aged 6 months or older who do not have contraindications. The CDC estimates that flu vaccination coverage among adults was 37% for the 2017-2018 season and 43% for the 2016-2017 season.
Last year’s flu season was particularly severe, with a record-breaking 900,000 hospitalizations and more than 80,000 deaths in the United States. Although most flu deaths were in adults older than 65, the flu also killed 180 children and teenagers.
Many survey respondents did not know this. About two thirds (63%) incorrectly believed that last year’s season was about the same as usual, was less severe than usual, or they did not know. People who had already received their flu shot for this season were more aware of the severity of last year’s flu season; 43% of people who had already been vaccinated correctly identified last year’s season as being more severe than usual, compared to only 30% of people who do not plan to get vaccinated.
“Flu vaccination helps prevent people from getting sick with the flu and reduces the severity of illness for those who do get sick. Widespread vaccination also helps create ‘herd immunity’ that protects vulnerable groups who are prevented from getting vaccinated,” Caroline Pearson, BA, senior fellow at NORC, said in news release. “Unfortunately, over half of all adults are currently unvaccinated, with four in 10 not intending to get vaccinated, placing themselves and those around them at risk.”

CMS: Health Spending Growth Slowed to 3.9% in 2017


National health spending rose 3.9% in 2017 — a slower growth rate than the previous 2 years — mainly due to a slowdown in use and intensity of hospital care, physician and clinical services, and prescription drugs, the Centers for Medicare & Medicaid Services (CMS) said Thursday.
Spending reached $3.5 trillion, but grew more slowly than in 2016, when it increased by 4.8%, or 2015, when it grew by 5.8%, according to Anne Martin, lead author of the report and an economist in the National Health Statistics Group at CMS’s Office of the Actuary, who spoke on a phone call with reporters. The 2017 health spending growth of 3.9% is lower than the 4.2% increase the gross domestic product (GDP) for 2017; healthcare’s share of the GDP was 17.9%, similar to 2016.
The slowing growth rate compared with the last 2 years “is a pleasant surprise, in part because as the economy improves you worry that one of the unintended consequences … is that we might see an increase in spending, but that doesn’t appear to be happening,” Gail Wilensky, PhD, who served as CMS administrator under President George H.W. Bush, said in a phone interview. “It is especially promising as we’re continuing a 20-year cycle of having Baby Boomers age into Medicare,” although a single year of decrease doesn’t necessarily mean a trend, added Wilensky, a senior fellow at Project HOPE, in Bethesda, Md.
In terms of spending by sector, spending on physician and clinical services, rose 4.2%, down from 5.6% in 2016, Martin said. The rate of spending growth for retail prescription drugs also fell, from 2.3% in 2016 to 0.4% in 2017 — the slowest growth rate since 2010 — while spending growth for hospital care dropped from 5.6% in 2016 to 4.6% in 2017.
The drop in physician and clinical services spending could be impacted by a number of factors that CMS doesn’t specifically estimate numbers for, such as “[more use of] high-deductible health plans, which would affect physicans and clinics, and a shift in the site of care as you have services traditionally consumed in other settings being consumed in clinical and freestanding settings that they weren’t previously,” said Aaron Catlin, a coauthor of the report, who is also with the National Health Statistics Group at CMS. “What we can tell you is that price growth increased [only] slightly in 2017 for physicians and clinics, so the indications are that use and intensity have slowed.”
As for the slower growth in drug spending, that may have occurred because, while there was a large spending increase in 2014 due to the advent of expensive hepatitis C treatments, “[that growth] subsided as many were cured of the disease,” Martin said. “In addition, more spending is continuing to go to lower-cost generics, and price increases also have slowed.”
Marsha Simon, PhD, a healthcare consultant here, said she found it “concerning” that state and local Medicaid expenditures grew at 6.4% — “well in excess of GDP growth, while federal Medicaid expenditures increased just a modest 0.8% in 2017. State and local governments have fewer tools to absorb cost increases than the federal government — for example, all but one state is barred from deficit spending. As the federal share of the Affordable Care Act (ACA) expansion population continues to decline, so will state and local Medicaid costs continue to increase.”
“These data point to the need to achieve savings by allowing states to modernize the administration of Medicaid by eliminating outdated federal requirements such as permitting only government employees to determine and re-determine eligibility for Medicaid,” she said in an email. “This requirement impedes the adoption of integrated state health enrollment systems to better serve poor families, since the Children’s Health Insurance Program (CHIP) has no such requirement. It also prevents states from improving Medicaid program integrity.”
Ed Haislmaier, senior research fellow at the Heritage Foundation, a right-leaning think tank here, said in a phone interview that he found it interesting that “they’re attributing the slowdown in hospital and physician services to changes in volume and mix but not price, whereas you’ve seen decreasing prices playing a factor with drugs. That suggests that inflation — in the pure sense of price change — is pretty well under control in this sector, which hasn’t been the case in the past.”
The slowdown in drug price growth is not a surprise despite the sharp increases in price for some existing drugs and the introduction of new treatments with six-figure price tags, mainly because so few people overall are taking those pricey medications, Haislmaier said. “This is the problem people have — they see a large number associated with unit cost and they don’t understand the significant difference between the aggregate in the system and the unit cost … Yes, there are expensive cancer drugs, but 85% of all prescriptions are for generics.”
Joe Antos, PhD, scholar in health care and retirement policy at the American Enterprise Institute, another conservative think tank, was amused by the title of the Health Affairs article that discussed the results, which included the subheading “Growth Slows to Post-Great Recession rates.”
“Somebody blew this big time; we’ve been at ‘post-Great Recession’ since 2010, including in 2017,” he said in a phone interview. “It really just means that the slowdown we’ve seen since that recession has continued, remarkably enough.”
While this report was definitely a positive, “having one more year of slow spending raises the question of will this good news continue indefinitely into the future,” Antos said. Although there is somewhat of a dark shadow on the spending horizon with the retiring Baby Boomers, “are we going to see things turn around dramatically? No, it happens more gradually, but a reasonable prediction is that sometime in the next 10 years, even if these good numbers hold out for a long time, we’re going to begin to see a turnaround … The question in our minds always is, when are we going to see a change?”

Forget Hong Kong, Grail is now going for a 2019 IPO in the US


In testament to the murky sentiment hanging over the Hong Kong stock exchange — and hot on a record-breaking streak of public debuts stateside — high-flying cancer testing startup Grail has reportedly dropped its plans for a Hong Kong listing in favor of the US market.
Months after getting the scoop on Grail’s intention to list on the HKEX, Bloomberg is now reporting that Grail is mulling a US IPO instead, with a filing expected as early as 2019, citing unnamed sources.
The company, backed by Bill Gates and Jeff Bezos, has not responded to the reports.

The Menlo Park, CA-based company has not, however, stayed silent about its aggressive fundraising. In May, Grail scored $300 million from Ally Bridge Group and other marquee Chinese investors including Hillhouse Capital Group, 6 Dimensions Capital, Blue Pool Capital, Sequoia Capital China and WuXi NextCODE. Pitchbook data, as cited by Bloomberg, puts its private valuation at about $3.2 billion.
When Hong Kong first opened up its stock exchange to pre-revenue biotechs, Grail and fellow US biotech unicorn Moderna were rumoured to be the two overseas big shots who would be enticed by the prospects of listing in the Asian financial hub. Moderna has since filed a record $600 million IPO on the Nasdaq, while the first few companies listed on the HKEX have given some investors pause with underwhelming performances.

These weak performances, combined with an increase in market volatility, are the chief reasons behind Grail’s change of heart, the report suggested.
Steering Grail to the potential IPO will be Genentech vet and CEO Jennifer Cook as well as George Golumbeski, who joined as president after leaving a lengthy dealmaking career with Celgene.

Moderna 26M share IPO priced at $23.00


https://thefly.com/landingPageNews.php?id=2833457

Fresenius makes a flurry of deals in Chinese dialysis clinics and hospitals


Fresenius Medical Care has moved to dramatically widen its footprint in China’s dialysis market, acquiring large shares in multiple Chinese companies and hospital systems across the country.
The German company bought a 70% share of the dialysis-focused Guangzhou KangNiDaiSi Medical Investment Co., which is currently building three independent treatment centers in Guangzhou and Zhaoqing in southeast China, with a proposal for a fourth awaiting government approval.
Fresenius also netted 55% stakes in Henan Aishen Hospital Management Co. and Aishen Beijing Hospital Management Co., which are building 13 more dialysis centers and a grade I renal hospital.
That will add to Henan Aishen and Aishen Beijing’s dialysis care network spanning the country’s Henan, Shandong, Guangdong and Hainan provinces. Finally, Fresenius also acquired a 60% share in Daqing Kangda Dialysis Center Co., in the northeastern Heilongjiang province.
“These acquisitions mark an important strategic step in our business development in China,” Fresenius CEO Rice Powell said in a statement. “As the second largest product market, China is already today an important business growth driver for Fresenius Medical Care.
The flurry of acquisitions follows up on its 2017 purchase of Yunnan Kunming Wuhua Healthcare Hospital, as well as newly disclosed acquisitions of 70% shares apiece in Sichuan Hejiang Kangcheng Renal Hospital and Sichuan Ziyang Zhongxin Hospital, both in the Sichuan province, from this past summer.
“We have been continuously investing in enhancing our product range within the local market. We have also started to enter the provider business to introduce advanced dialysis services and operations management in China,” Powell said.
Chronic kidney disease affects just over 10% of China’s population, totaling more than 120 million people, Fresenius said. Citing figures from the Chinese Society of Nephrology, the company says there are currently 1 million registered patients with end-stage renal disease, but only about half receive dialysis treatment.
“As a leading provider of dialysis products and services in China, we are eager to work with other companies that are dedicated to elevating the treatment of kidney disease in this huge country,” said Harry de Wit, CEO of Fresenius Medical Care Asia-Pacific. “In particular, we focus on increasing access to treatment in rural areas, where there have traditionally been fewer options for patients.”
In a note to clients, analysts at Bernstein said the Chinese dialysis market ranks second behind the U.S. in terms of patient count, and estimated that the number of China’s dialysis patients is currently growing between 15% and 20% per year.

Big pharma’s off-patent drugs lose out in China’s new price-cutting scheme


In a Battle of Waterloo-style defeat, off-patent drugs from big pharma firms lost major markets in China as the government adopted a novel procurement scheme to slash generic drug costs. But after steep price cuts, local firms aren’t considered winners, either.
Among the 31 drugs China’s newly formed health insurance watchdog listed for procurement in a pilot program, multinational pharmas participated in bidding to supply almost all of them, but landed only two contracts, according to multiple local reports of preliminary tender results.
The drugs all have generic versions available in China and include prominent brands such as Pfizer’s Lipitor, AstraZeneca’s Crestor, Sanofi’s Plavix, Gilead’s antiviral Viread (marketed by GSK in China), Novartis’ Gleevec and Lilly’s Alimta, among others. In the end, only AstraZeneca’s EGFR inhibitor Iressa and Bristol-Myers Squibb’s heart drug Monopril won their fights against local copycats.
Just how important is the procurement?
The Chinese government is testing a bulk purchase scheme for 11 major cities, including Beijing and Shanghai. On average, these cities make up about 30% of China’s total drug sales, local media reported. Each city calculated its annual demand at public hospitals—where most prescriptions in China are filled—for each drug and allocated around 30% to 50% share of that purchasing to a bidding pool, down from the previously rumored 60% to 70%, according to a tally by brokerage firm China Galaxy Securities as cited by local publication Healthcare Executive.
The winner takes all: The successful bidder on a particular drug walks away with the entire guaranteed purchase amount from all 11 cities.
Pocketing that kind of huge market should be a huge win for drugmakers. Why, then, did the MSCI China Health Care Index fall 8.4% Thursday, its largest decline since 2009, according to Bloomberg? As with any government-led drug purchases in China, huge price cuts are expected. Not to mention this is the first time drug procurement bids carried purchase amount promises with them.

The fight on this initial round was brutal to say the least. According to local reports, for drugs with three or more bidders, the lowest tender price was automatically chosen. Chia-tai Tianqing Pharma, for instance, cut its price by 90% to win a contract for hepatitis B treatment entecavir, as a generic to BMS’ Baraclude. Shares in the Chinese company’s parent firm, Sino Biopharmaceutical, plummeted 14% in Hong Kong Thursday.
While the official results have yet to be announced, the size of the price cuts appear to have gone beyond market expectations, and the example put a chilling effect on biopharma companies that didn’t even make the cut this time. Fosun Pharma saw its shares tumble 8.6% at the news. Even Chinese CRO giant WuXi AppTec dropped more than 6%. One of the few exceptions was Zhejiang Huahai Pharmaceutical, whose carcinogen-tainted valsartan API triggered a global recall recently. After it reportedly won the most tenders—six in total—its stock climbed 3%.
For all biopharma companies, foreign or domestic alike, winning such bulk purchase bids represent a dilemma. On the one hand, it means a sizeable secured market and savings on marketing efforts; but on the other, lowering prices significantly could put profits at risk.
The new procurement scheme comes at a time when China is pushing for wider adoption of generic drugs to drive down overall health spending and make room to adopt new innovative drugs in its national drug reimbursement system.
It could mean a bumpy road ahead for Big Pharma companies, which have enjoyed fast growth in China, thanks in part to some legacy drugs. For a long time, foreign pharma’s original drugs were considered better in China and were not placed in direct competition with local copycats. But those days are gone as the Chinese government inches forward with a campaign to evaluate the bioequivalence between domestically-made generics and their originators.