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Friday, February 19, 2021

AstraZeneca/Oxford vaccine more effective with longer dose gap: study

 AstraZeneca and Oxford University’s COVID-19 vaccine is more effective when its second dose is given three months after the first, instead of six weeks, a peer-reviewed study published in The Lancet medical journal showed on Friday.

The study confirmed the Anglo-Swedish drugmaker’s findings from earlier this month that showed the vaccine had 76% efficacy against symptomatic coronavirus infection for three months after the first dose.

Efficacy was found to be at 81% with the longer interval of 12 weeks between the first and second dose, compared with 55% efficacy up to the six-week gap, according to the Lancet study, which backs British and WHO recommendations for longer intervals. (bit.ly/3bmLX25)

Faced with a resurgence in infections and new, highly transmissible variants of the virus, many countries are hoping to broaden immunization by giving some protection to as many people as possible with a first dose, while delaying subsequent shots.

https://www.reuters.com/article/us-health-coronavirus-astrazeneca/astrazeneca-oxford-vaccine-more-effective-with-longer-dose-gap-study-idUSKBN2AJ1WZ

Dynavax: EC Marketing Authorization for HEPLISAV B 2 Dose Adult Hep B Vax


-- Approval follows positive opinion by European Committee for Medicinal Products for Human Use

-- Approval based on safety and immunogenicity results from three Phase 3 clinical trials

-- Statistically significantly higher and faster rates of protection and similar safety compared to Engerix-B in all 3 trials

-- HEPLISAV B is the only 2-dose adult hepatitis B vaccine offering protection in just 1 month

https://finance.yahoo.com/news/dynavax-announces-european-commission-marketing-172000389.html

Galapagos (NASDAQ:GLPG) Raised to Outperform at Raymond James

 Galapagos (NASDAQ:GLPG) was upgraded by investment analysts at Raymond James from a "market perform" rating to an "outperform" rating in a report released on Friday, Analyst Ratings Network reports.

https://www.marketbeat.com/instant-alerts/nasdaq-glpg-a-buy-or-sell-right-now-2021-02/

FDA: COVID-19 Not Transmitted by Food or Packaging

 There is no evidence you can catch coronavirus through food or food packaging, the FDA and other government agencies said Thursday.

Since the pandemic began more than a year ago, the CDC and other health agencies have said they're pretty certain the virus is not transmitted through food or food packages. The latest statement reconfirmed that idea.

"After more than a year since the coronavirus disease 2019 (COVID-19) outbreak was declared a global health emergency, the U.S. Department of Agriculture, the U.S. Food and Drug Administration and the U.S. Centers for Disease Control and Prevention continue to underscore that there is no credible evidence of food or food packaging associated with or as a likely source of viral transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19," said the statement attributed to Janet Woodcock, MD, acting commissioner of food and drugs at the U.S. Food and Drug Administration.

The statement noted that COVID-19 is a respiratory illness spread person to person. Some researchers found small amounts of virus particles on food or food packaging, but infection usually requires a much higher number of particles, the statement said.

The statement said there's an "international consensus" that the chances of infection from touching food packaging or eating food is extremely low, such as the recent opinion from the International Commission on Microbiological Specifications for Foods

"Based on the scientific information that continues to be made available over the course of the pandemic, the USDA and FDA continue to be confident in the safety of the food available to American consumers and exported to international customers," the statement said.

Sources:

FDA. "COVID-19 Update: USDA, FDA Underscore Current Epidemiologic and Scientific Information Indicating No Transmission of COVID-19 Through Food or Food Packaging."

CDC. "Food and Coronavirus Disease 2019 (COVID-19)."

ICMF. "ICMSF Opinion on SARS-CoV-2 and its relationship to food safety."

https://www.medscape.com/viewarticle/946116

Biden to Pledge $4 Bln to COVAX Vaccine Program at G7 Meeting Friday

 The Biden administration will pledge $4 billion to a vaccination program for poorer countries at a global economic summit on Friday in hopes that other countries will follow suit and contribute additional funds, U.S. officials said on a Thursday press call.

At a meeting of the Group of Seven nations, a summit for the world'’s largest economies, the White House will announce plans to immediately grant $2 billion to the international COVAX program, which aims to ensure a fair supply of coronavirus vaccines around the world, officials said.

The United States will supply the remaining $2 billion over the next two years as other nations fulfill their own pledges, the officials said. The funding was approved by Congress earlier this month.

https://www.medscape.com/viewarticle/946108

'Final word': Vaccinating Teachers to Reopen Schools 'Not Doable'

 Vaccinating all teachers against COVID-19 before schools reopen isn't doable, Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said Wednesday.

"If you are going to say that every single teacher needs to be vaccinated before you get back to school, I believe quite frankly that's a non-workable situation," he said on CBS This Morning.

Fauci, who also serves as President Joe Biden's chief medical adviser, added that teachers should "absolutely" be prioritized as essential workers in immunization eligibility schedules. However, schools shouldn't remain closed until every teacher is vaccinated, he said.

"You should try to get as many teachers as you possibly can vaccinated as quickly as you possibly can," he said. "You don't want to essentially have nobody in school until all the teachers get vaccinated."

Reopening schools has become a major question under the Biden administration, with some officials unable to provide clear answers, according to Politico. During a town hall on Tuesday, Biden said his goal is to reopen K-8 schools by the end of the first 100 days of his administration.

Earlier this month, Rochelle Walensky, director of the CDC, also said that teachers don't need to be vaccinated for schools to open safely again. On Wednesday, Jen Psaki, the White House press secretary, agreed that vaccinating teachers isn't necessary for reopening schools, according to The Hill .

"Neither the president nor the vice president believe that it is a requirement," Psaki said during a press briefing.

"At the same time, the president and vice president also believe that teachers should be prioritized," she said. "That's up to states to determine."

The CDC's Operational Strategy for K-12 Schools, which was released on Friday, says vaccinating teachers offers an "additional layer of protection" against COVID-19 but that it shouldn't be required to reopen in-person learning. The guidelines emphasize social distancing and masking, along with smaller class sizes and monitoring of COVID-19 transmission at the local level.

"It is critical for schools to open as safely and as soon as possible, and remain open, to achieve the benefits of in-person learning and key support services," according to the CDC guidance.

"To enable schools to open safely and remain open, it is important to adopt and consistently implement actions to slow the spread of SARS-CoV-2 both in schools and in the community," the guidance says.

Sources

CBS News, "Dr. Fauci on COVID-19 vaccination efforts."

Politico, "Fauci: 'Non-workable' to vaccinate teachers before schools open."

The Hill, "White House says teacher vaccinations not required for schools to reopen."

CDC, "Operational Strategy for K-12 Schools through Phased Mitigation."

https://www.medscape.com/viewarticle/946124

Nursing schools see enrollment bump amid pandemic

 Last December, Mirande Gross graduated from Bellarmine University in Louisville, Kentucky, with a bachelor’s degree in communications. But Gross has changed her mind and is heading back to school in May for a one-year accelerated nursing degree program. The pandemic that has sickened more than 27 million people in the United States and killed nearly 500,000 helped convince her she wanted to become a nurse.

“I was excited about working during the pandemic,” Gross, 22, said. “It didn’t scare me away.”

Enrollment in baccalaureate nursing programs increased nearly 6% in 2020, to 250,856, according to preliminary results from an annual survey of 900 nursing schools by the American Association of Colleges of Nursing.

“In the pandemic, we saw an increased visibility of nurses, and I think that’s been inspirational to many people,” said Deb Trautman, president and CEO of the association, whose members represent nursing programs at the bachelor’s, masters and doctoral levels. “It’s a profession where you can make a difference.”

Two-year associate nursing degree programs seem to be experiencing a similar bump, though hard numbers are unavailable, said Laura Schmidt, president of the Organization for Associate Degree Nursing.

There’s no way to know exactly what is propelling the new applications. But medical schools also saw an 18% boost in applications last year, a jump partly attributed to the pandemic and high profile of key doctors, such as Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, during the crisis.


It’s possible that the media stories, social media accounts and front-line medical workers’ personal accounts of battling the novel coronavirus have played a role. “Nurse” was the No. 1 term that people queried “how to become” on Google in 2020, according to Google trends data.

For Gross, it was a turn back to an initial career choice. When she started college, nursing was her chosen path. But after fainting twice while shadowing a nurse at the hospital, she switched to a major that didn’t involve needles or blood. For the past two years, she’s worked as a newborn photographer at a hospital near her Louisville home, and she no longer gets squeamish at the sight of IVs or injuries.

“When I saw on the news nurses being so overworked, I thought, ‘Gosh, I wish I could be in there helping,’” said Gross.

Demand for nurses was strong even before the pandemic hit. There are about 3 million registered nurses in the United States, but employment is expected to grow 7% between 2019 and 2029, according to the Bureau of Labor Statistics, faster than the 4% average for all occupations. Many hospital medical staffs are stretched to the breaking point as they deal with a surge of COVID-19 patients and at the same time cope with staff shortages as medical personnel have become ill with COVID or had to quarantine.

Meeting the demand for nurses is hampered by long-standing capacity issues at nursing schools. According to a report by the American Association of Colleges of Nursing, programs at the bachelor’s and graduate degree levels turned away more than 80,000 qualified applicants in 2019. The reasons included not having enough faculty, clinical training sites and supervisors or classroom space, as well as budget constraints, the report found.

“The people who are prepared to teach are at least master’s degree level and frequently have doctorate degrees,” said Beverly Malone, president and CEO of the National League for Nursing. “They can work at hospitals or community care centers for [significantly] more money.”


Malone and others also noted that it can be difficult to ensure access to the clinical training slots that nursing students need. This problem was exacerbated during the pandemic when many hospitals sent nursing students home to avoid their getting sick and to conserve scarce personal protective equipment for staffers treating covid patients.

For some nursing students, the pandemic has opened their eyes to new possibilities for patient care. David Namnath is finishing a two-year associate nursing degree at the College of Marin in Kentfield, California. He learned last spring that his clinical rotation at the local hospital would be canceled because of covid.

Instead, he and other students took on a telenursing project, in which he made regular wellness check-ins and provided health education related to chronic conditions such as diabetes and back pain with eight patients over video and phone.

“It was really helpful for me,” said Namnath, 29, who has a bachelor’s degree in biochemistry and worked in a lab before starting nursing school. “It’s not something you normally learn. I think we became more three-dimensional because of it.”

Some people who got nursing degrees in years past but didn’t practice also may be taking a fresh look at the profession, said David Benton, CEO of the National Council of State Boards of Nursing. More than 222,000 nurses who were educated in the U.S. took the National Council Licensure Examination last year, a figure that was 5% higher than the year before, he said.

The economic downturn that has shuttered thousands of businesses may have made nursing more attractive, he said.

“We know that, nationally, services like the restaurant industry have shut down,” Benton said. “But one thing that hasn’t shut down is demand for health care.”

Nurses who worked in hospitals made $79,400 a year on average in 2019, according to the Bureau of Labor Statistics. But as the covid crisis hit and hospitals scrambled to find staff last year, nurses who were willing to travel to covid hot spots could make many times that amount, in some cases up to $10,000 a week.


There are many paths to becoming a nurse. A growing proportion of nurses get a bachelor of science degree in nursing at four-year colleges. But many still go to community colleges for two-year associate degrees in nursing. These programs are more affordable and may appeal to older students who are parents or going back for a second degree, said Schmidt.

Both types of graduates can take the nurse licensing exam and become registered nurses. But nurses with bachelor’s degrees may be better positioned for higher-level jobs or supervisory roles. They may also earn more money. According to the association of nursing colleges’ annual survey, 41% of hospitals and other health care facilities require new nursing hires to have a bachelor’s degree in nursing.

Many nursing schools have “RN to BSN” programs that enable registered nurses with associate degrees to get the additional training they need for their bachelor of nursing degrees. And numerous accelerated programs, like the one Mirande Gross will start in May, allow people to fill in their nursing education gaps in a compressed time frame.

Not every nursing student sees the pandemic as an opportunity, however. Steven Bemben worked as a paramedic in Uvalde County, Texas, west of San Antonio, during the first frightening months of the pandemic last year. Personal protective equipment was hard to come by, and sometimes the calls to transport very sick covid patients came nonstop.

“It was extremely stressful, and people were getting fatigued and burned out,” said Bemben, 33, who had been on the job for nine years.

Last October, he quit his paramedic job, and in January he started a two-year bachelor’s nursing program at the University of Texas-San Antonio. (He already has an associate degree, although not in nursing.)

When Bemben finishes school, he hopes, the pandemic will be in our collective rearview mirror.

“By the time I graduate, I’m trying to stay optimistic that we’ll be past all this stuff,” he said.

https://www.fiercehealthcare.com/practices/i-wanted-to-go-there-and-help-nursing-schools-see-enrollment-bump-amid-pandemic