Video posted to social media showed burned out and burning vehicles as violence spread across the city, closing the airport.
Ovidio Guzman, a son of incarcerated Guzman, was arrested by Mexican authorities, five officials familiar with the matter told Reuters on Thursday.
News of the capture came after a night of violence in Culiacan in the northern state of Sinaloa, home to the drug cartel of the same name, and one of the world's most powerful narcotics trafficking organizations.
Two days before the FDA is expected to make a decision onBiogen andEisai's lecanemab, another death possibly linked to the Alzheimer's drug came to light, courtesy of aletterpublished Wednesday in theNew England Journal of Medicine.
The letter to the editor, written by Nicholas J. Reish, M.D., Ph.D. and other physicians at Northwestern, outlines the case of a 65-year-old patient with early Alzheimer’s. The patient had participated in both the randomized Phase III Clarity-AD trial and received three intravenous infusions of the anti-amyloid antibody in the open-label phase.
The patient had cerebral amyloid angiopathy (CAA), according to the autopsy report. CAA is a cerebrovascular disorder in which amyloid beta-peptide accumulates in the walls of small-to-medium-sized cerebral blood vessels and meninges.
Upon suffering a stroke, the patient was treated with intravenous tissue plasminogen activator (t-PA), an emergency stroke-busting medication. According to the authors, the patient then experienced “numerous acute intracerebral hemorrhages” and subsequently died.
The authors went on to write that “the extensive number and variation in sizes of the cerebral hemorrhages in this patient would be unusual as a complication of t-PA solely related to cerebrovascular amyloid.”
The findings “raise the possibility of cerebral hemorrhages and necrotizing vasculopathy associated with t-PA infusion in a patient with cerebrovascular amyloid who had received lecanemab,” the authors concluded.
In a response also published Wednesday in NEJM, Drs. Marwan Sabbagh, M.D. of the Barrow Neurological Institute and Christopher H. van Dyck, M.D. of the Yale School of Medicine agreed that the case “raises important management issues”, particularly for patients who are homozygous for the APOE ε4 allele.
Sabbagh presented data from Clarity-AD at the 2022 Clinical Trials on Alzheimer's Disease (CTAD) conference in November, where he addressed two deaths that had previously been linked to lecanemab.
In October, an unnamed Clarity-AD investigator attributed a patient’s death to lecanemab. The following month, one day ahead of the CTAD presentation, a report in Science linked a second patient’s death to the drug. Both deaths occurred due to bleeding in the brain.
Sabbagh and Dyck suggested that other factors, including high blood pressure and vasculitis, might have contributed to the stroke patient’s death. They went on to point out that there have been fatal intracerebral hemorrhages after t-PA treatment in people with CAA who were not taking anti-amyloid medications.
BioSpace has reached out to Eisai for additional comment and will update this story accordingly.
Biogen and Eisai have a date with the FDA on Jan. 6.
Multi-year collaboration focuses on three strategic pillars: cancer immunotherapies, infectious disease vaccines, and expansion of BioNTech’s footprint in the UK
BioNTech aims to design and roll out randomized clinical trials with registrational potential for the Company’s personalized mRNA cancer immunotherapies in the UK
Accelerated clinical trial recruitment with first patient to be enrolled in a trial as part of this collaboration in H2 2023
Set-up of an R&D hub in Cambridge (UK) with the aim to employ more than 70 highly skilled scientists with the first employees commencing work in Q1 2023
In the latest sign that Washington is not backing down from its ramped-up military support to the democratic island of Taiwan, and at a moment repeat PLA aircraft incursions have continued their intensity, the US Navy hassailed another destroyer through the Taiwan Strait.
The Navy's 7th Fleet announced Thursday its guided-missile destroyer Chung-Hoon made the passage as part of its commitment to a "free and open Indo-Pacific."
"The Arleigh Burke-class guided-missile destroyer USS Chung-Hoon conducted a routine Taiwan Strait transit Jan. 5 (local time) through waters where high-seas freedoms of navigation and overflight apply in accordance with international law," the Navy's 7th Fleet Public Affairs office announced.
"Chung-Hoon’s transit through the Taiwan Strait demonstrates the United States’ commitment to a free and open Indo-Pacific," the Navy added.
Last month China's Foreign Ministry accused the Pentagon of seeking to create new tensions across the Taiwan Strait with its provocative sail-throughs. At the same time the Chinese military has on multiple occasions in recent months breached the Taiwan Strait median line both in the air and at sea - a pattern which grew only after Nancy Pelosi's provocative August visit to Taipei.
China’s warplane incursions into Taiwan's air defense zone nearly doubled in 2022 compared to the year before as Newsweek reviews of the numbers:
Chinese military aircraft, mostly fighter jets, were detected in the island's air defense identification zone, east of the Taiwan Strait median line, on 1,737 occasions in 2022, up from 972 in the previous 12 months, statistics compiled by U.S.-based analysts Gerald Brown and Ben Lewis revealed.
Meanwhile, as we noted earlier this week, Xi's newly appointed Chinese Foreign Minister Qin Gang is busy attempting a 'softening' and breakthrough in US-China relations.
After taking over the post last Friday, before which he served as the ambassador to the US, he wrote in a new Washington Post op-ed published Wednesday that US-China competition "should not be a zero-sum game," arguing further that "The world is wide enough for China and the US to both develop and prosper."
He asserted that "decoupling serves no one’s interest", but that healthy relations including economic cooperation "will remain an important mission" in his new role as Beijing's top diplomat, but it remains that "Improving relations takes work by both sides," he wrote.
Qin called for 'stability' in relations, ironically just ahead of next week's US-Taiwan official trade delegation talks in defiance of China's condemnations.
As South China Morning Post underscores, the White House is involved: "The trip – a rare visit of US executive branch officials to Taiwan since President Joe Biden took office – will mark the second round of face-to-face talks on the trade initiative and the first held on the island. Washington and Taipei agreed to the talks in June," the report detailed.
A new California law, allowing men who identify as female to be housed in women’s prisons, is wreaking havoc within the women’s prison system and creating an environment of fear and “total chaos emotionally,” according to Amie Ichikawa, a plaintiff in a lawsuit which seeks to overturn it.
“It’s the worst human science project I’ve ever seen,” she said during a recent episode of EpochTV’s California Insider.
“This is very callous and brazen psychological warfare that is occurring right in our own state being fully funded by taxpayers’ dollars.”
Ichikawa, at 24, was incarcerated at the Central California Women’s Facility in Chowchilla for five years. She recently founded the nonprofit Woman II Woman, which provides resources, education, and support for currently incarcerated women.
She said since 2020 when California Gov. Gavin Newsom signed the bill—named The Transgender Respect, Agency, and Dignity Act and authored by California State Sen. Scott Wiener (D-San Francisco)—she has received more phone calls, emails, and letters than she can count from incarcerated women in fear of their safety, post-traumatic disorder triggers, pregnancy, and STDs.
“How could they do this to us?” she said, was their theme.
California women’s cells now house eight inmates each, she said—extremely close living quarters of about 6-feet per inmate, leading to concerns by some female prisoners they may end up housed with a man—who now identifies as female—who has raped, for example, or who has “predatory intentions.”
“That’s a very tight space to share with anyone,” she said.
“But even more so with someone who has a history of violence against women.”
Ichikawa, now 40, said she realizes there is no privacy in prison, but with the new law, “there is no dignity either,” as some transfers are and will be full-bodied males, sharing what was once single-sex space.
The law allows an inmate who identifies as transgender, non-binary, or intersex to be housed, at their choice, with either male or female prisoners. By all accounts, it was written to help the transgender community feel more comfortable if incarcerated.
But according to Ichikawa, it has not benefited anyone.
“It has really created a toxic, diabolical situation of … the prison of the mind,” she said.
“People are afraid. Women are afraid to say anything. It’s crippling.”
She said there have been 40 such cases of men being transferred to women’s prisons since the law went into effect in January of 2021 and there are currently nearly 300 more applications in the pipeline, with more than one-third from inmates who are registered sex offenders.
According to Ichikawa, typically about 17 percent of California’s incarcerated are registered as such.
“That’s a big jump,” she said.
Some, she said, are men capitalizing on the law to move from typically more dangerous lockdowns because it’s easy to do so, with few requirements for a transfer other than self-identification.
“This is open season for anyone who wants to get out of the men’s prisons,” she said.
“There are very few reasons why someone would not want to take advantage,” of this.
In the 30-minute interview, she said there is no evidence of any women, so far, becoming harmed in the new arrangement.
But, she said, some female inmates have lodged complaints and then were retaliated against for doing so by prison authorities, who called such “harassment.”
Ichikawa additionally said currently incarcerated women were given little preparation for the change, but said she learned from some that a poster was introduced in one woman’s prison detailing options in the event of pregnancy. Condoms, she said, are also now dispensed.
“Those were never available before in women’s prisons,” she said.
She said she was also shocked to learn only nine California lawmakers voted against the bill, and that the California Women’s Legislative Caucus, composed of dozens of female Senators and Assemblymembers, backed it.
“It took my breath away to learn how much support was behind this,” she said.
“I didn’t know so many elected officials hated women so much.”
And, she said, she doesn’t think it’s stopping in California.
“This has got to be a nationwide, even a global movement to erase women,” Ichikawa said.
She said lawmakers who passed the bill didn’t fully understand its ramifications.
“Any adult breathing and with a pulse can see it will create a huge problem when you take a whole population and handpick a little part of it and give them all these privileges. It’s going to be dangerous,” she said.
She said she believed politicians got caught up in today’s ideological culture wars and were “fooled by pretty language, inclusive words.”
Ichikawa’s lawsuit, filed in November of 2021 in the U.S. District Court, Eastern District of California, Fresno, alleges the law violates the federal and state rights of women currently incarcerated in California’s prisons.
If approved, glofitamab would be the first fixed-duration CD20xCD3 T-cell engaging bispecific antibody approved to treat the most aggressive type of non-Hodgkin lymphoma
Results from the pivotal phase I/II NP30179 study showed glofitamab induced durable response rates in people with heavily pre-treated large B-cell lymphoma, with 40% achieving a complete response
Glofitamab is part of Roche’s industry-leading portfolio of T-cell engaging bispecific antibodies, which also includes the newly FDA-approved first-in-class Lunsumio to treat follicular lymphoma
Just 327 unrepentant crooks accounted for 30% of the Big Apple’s 22,000shoplifting arrests last year, the NYPD said Thursday.
The staggering statistics mean the alleged recidivists got busted a total of about 6,600 times — for an average of more than 20 times each.
But even more alarming is where most of them are now — which is right back on the streets, NYPD Chief of Crime Control Strategies Michael Lipetri said during a briefing on 2022’s CompStat numbers.
“We arrested 327 people, 327 people that account for 30% of all the arrests,” he said. “All the arrests — 327 people are 30% of our 22,000.”
Lipetri also said that “about half” of the group were “convicted felons.”
Just 327 unrepentant crooks accounted for 30% of the Big Apple’s 22,000 shoplifting arrests last year.William Farrington
“And guess what? Two hundred thirty-five of them — so 235 out of 327 — are walking around the streets of New York right now,” he said. “Just doing what? Unfortunately, making stores close or making families wait 15 minutes 20 minutes to get something unlocked — because there’s not a lot of consequences.”
New York’s controversial, 2019 bail reform law generally prohibits judges from setting bail in cases involving non-violent felonies and misdemeanors such as shoplifting.
Mayor Eric Adams, who’s been calling on state lawmakers to roll back bail reform, said Thursday that he planned to “return to Albany this year to talk about things like, how do we look at recidivism?”
The alleged recidivists got busted a total of about 6,600 times — for an average of more than 20 times each.Helayne Seidman
The Post has exclusively exposed several serial shoplifters, including self-proclaimed “professional booster” Michelle McKelley, “Teflon con” Charles Wold and “Man of Steal” Isaac Rodriguez — whose story led then-NYPD Commissioner Dermot Shea to tweet: “Insanity. No other way to describe the resulting crime that has flowed from disastrous bail reform law.”
Also during Thursday’s briefing at NYPD headquarters in Lower Manhattan, Chief of Patrol John Chell said the department’s low-profile Neighborhood Safety Teams seized 431 guns during 411 incidents that led to 501 arrests.
“One out of every four encounters resulted in a firearm being removed from the street,” Chell said.
The overall rate of major crimes increased by 22.4%, with double-digit spikes in five of the seven categories.Paul Martinka
