has revealed topline results from the Phase 3 National Institutes of Health's (NIH) ACTIV-2 trial that assessed SAB-185 in non-hospitalized COVID-19 patients at high risk for severe outcomes.
What Happened: SAB-185 demonstrated benefit in sustained symptom resolution of COVID-19 caused by Omicron compared to participants who received a monoclonal antibody cocktail, REGEN-COV, developed by Regeneron Pharmaceuticals Inc
Data Results: 66% of participants treated with SAB-185 reached full symptom resolution for at least four consecutive days by Day 28, while only 50% of participants on REGEN-COV met this endpoint (p=0.010).
The median time to symptom resolution for at least four consecutive days was seven days shorter for SAB-185.
Also, the median time to symptom resolution for at least two consecutive days was six days shorter for SAB-185 than those treated with REGEN-COV (p=0.021).
In the non-Omicron population, the median time to symptom resolution for at least four consecutive days was seven days shorter for SAB-185, and the median time to symptom resolution for at least two consecutive days was four days shorter for SAB-185 than REGEN-COV.
However, neither of these analyses met statistical significance.
Why It Matters: Last March, SAB Biotherapeutics said that due to low hospitalization and death rates in the trial, the National Institutes of Health's NIH ACTIV-2 Program discontinued enrollment in its Phase 3 COVID-19 trial.
The sponsors concluded that the potential efficacy of SAB 185 would not be possible to demonstrate statistically significant clinical efficacy with the existing study design.
"The ACTIV-2 data further validates the potential of SAB's platform. It shows that the DiversitAb™ platform can open the door to treatments that are potentially more effective and potent and which remain efficacious over longer periods versus monoclonal antibodies," said Eddie J. Sullivan, co-founder, President & CEO of SAB Biotherapeutics
If thugs were hurting your kid, you’d do almost anything to stop them.
The harm the teachers unions inflict is legalized thuggery.
Here’s what you can do.
The tragic consequences of union strong-arming will be on display Wednesday, when a House subcommittee grills American Federation of Teachers chief Randi Weingarten on how the unions muscled the Centers for Disease Control and Prevention in February 2021 into setting impossible-to-meet requirements for reopening schools during COVID.
Closing schools in spring 2020, when no one understood COVID, was understandable.
But once science showed negligible risk to students in returning to the classroom, prolonging closures became child abuse.
School closures led to severe learning loss, setting back many kids for years, possibly the rest of their lives.
“This is potentially going to be a real problem for this generation,” warns Oxford University researcher Bastian Betthäuser.
McKinsey & Company calls the impact on students’ basic skills “grim.”
A staggering 37% of high-school students reported suffering mental-health struggles during the lockdowns in a CDC survey.
Weingarten has already lawyered up for the hearing.
Expect fireworks but no concrete changes.
State laws, not Congress, determine what powers teachers unions have.
Listen up, parents.
Protecting your kids from the unions requires waging political warfare, state by state.
Action is urgently needed.
Since 2008, learning progress in public schools has stagnated, and American kids are falling behind their peers in other countries.
The COVID lockdowns dealt a devastating blow, but schools were in crisis long before that.
Laws in 38 states guarantee collective bargaining, not just over pay but often over every aspect of the school day, even curriculum.
Unions use these powers to block school reform, opposing standardized testing, merit pay and teacher accountability.
And to stuff the curriculum with political indoctrination — what the AFT calls “social justice.”
Florida Gov. Ron DeSantis has vocalized his plans to make changes to students’ curriculum.REUTERS/ Sarah Silbiger
The unions also buy political influence outright. The National Education Association and AFT — the nation’s two biggest teachers unions — are among the largest donors to politicians, and at least 94% of that money goes to Democrats, according to Open Secrets.
No wonder Biden’s White House ordered the CDC to grovel to Weingarten and the teachers unions.
They support Democrats handsomely and in return get what they want at the bargaining table.
The good news is that in red and purple states, reformers are pushing to change that.
Arkansas Gov. Sarah Huckabee is pushing teachers unions away from teaching about gender theory.POOL/AFP via Getty Images/ Al Drago
Five states are banning unions from deducting dues from teachers’ paychecks, making it harder to raise millions for political clout.
Indiana Gov. Eric Holcomb, Florida Gov. Ron DeSantis and Arkansas Gov. Sarah Huckabee Sanders are also moving to curb unions from dictating curriculum, such as teaching elementary-school kids gender theory instead of arithmetic and reading.
Unfortunately, deep-blue states like Illinois and New York are union captives.
That explains the otherwise inexplicably destructive policy New York’s State Education Department is adopting.
The SED is making the abysmal reading and math scores of kids tested just after the lockdowns ended the baseline or “new normal” against which future students will be measured.
That redefines “proficiency” down to rock bottom.
A teacher’s students only have to do as well as kids who were locked at home with no classroom time at all.
Weingarten has lawyered up for the hearing.STEFAN JEREMIAH
