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Tuesday, August 1, 2023

Feds hired NY health czar who defended deadly nursing-home order

 Exactly three years ago this week, then-state Health Commissioner Howard Zucker testified before the Legislature, delivering a full-throated defense of the Cuomo-Hochul administration’s nursing-home policy.

From a deadly March 25, 2020, nursing-home order, to the elaborate efforts to cover up its fatal consequences, the moment demanded truth, transparency and accountability.

Zucker was the wrong man for the job and failed miserably to deliver.

Meanwhile, with COVID tests in high demand and not readily available, friends and family of the Cuomo-Hochul administration were getting incredible VIP access that misallocated resources and abused power.

Zucker should have been fired on the spot, but instead, he failed upward and now serves in a senior position in the Biden Centers for Disease Control and Prevention.

Didn’t anyone at the White House look at his disastrous record?

Three years after that hearing, New Yorkers are still searching for accountability; Zucker’s Aug. 3, 2020, testimony was his first and only joint legislative hearing on the disastrous March directive.

After COVID-positive patients were ordered back into nursing homes to be placed with healthy seniors, thousands of residents died of the disease as a result.

Ambulance workers removing a COVID-19 patient from Cobble Hill Health Center nursing home in Brooklyn on April 17, 2020.
Ambulance workers removing a COVID-19 patient from Cobble Hill Health Center nursing home in Brooklyn on April 17, 2020.
Photo by Braulio Jatar/SOPA Images/LightRocket via Getty Images

There was no bureaucrat in a more powerful position to answer for this than Zucker. That August hearing was a moment of truth that proved to be anything but a proper accounting.

Just weeks before, he’d released a report drastically undercounting nursing-home deaths and attempting to clear the administration of wrongdoing.

Lawmakers wanted to examine inaccuracies with case counts and death tolls, how Zucker’s Department of Health was tracking nursing-home patients who received intensive-care from hospitals and other impacts of the deadly nursing-home order.

Zucker simply defended the policy, doubled down on his phony report and cynically blamed asymptomatic staff for the infections in the affected facilities.

The Cuomo administration released a report undercounting the deaths of COVID-19 patients in nursing home in 2020.
The Cuomo administration released a report undercounting the deaths of COVID-19 patients in nursing home in 2020.
Photo by Eduardo Munoz Alvarez/Getty Images

He claimed the state did not want to “double count” nursing-home deaths as the reason for spotty data.

At his behest, DOH refused to count patients as “nursing-home deaths” if they were moved from homes to hospitals before passing away.

New York was the only state in the country attempting this deceptive tactic.

Zucker came to the hearing empty-handed, without any new concrete figures.

He refused to answer for the heavy-editing work of the governor’s office to limit the count, and ultimately refused to show up for a follow-up hearing the week after.

Scandal and controversy plaguing Howard Zucker didn’t stop there.

While nursing homes were receiving an influx of COVID-positive patients, they were not able to adequately test patients and staff due to shortages.

Yet with an illegal and abusive assist from Zucker’s DOH, family and friends of the Cuomo-Hochul administration had the red carpet rolled out for them when it came to testing.

Every element of misappropriation was on display: Health Department staff would show up at private friends’ and families’ residences, and their test samples were given front-of-the-line attention at the state lab.

There was plenty of controversy over those Zuckerbucks used by Facebook’s Mark Zuckerberg to influence US elections, but far more attention should have been given to the Zuckerswabs used by Howard Zucker to benefit Cuomo-Hochul VIPs during COVID.

With all this, folks might think he surely was disciplined, fired, demoted or otherwise punished.

Wrong.

Turns out, he got a promotion — a big one: He’s now deputy director of global health at the CDC.

People protesting against New York's COVID-19 nursing home policy at a vigil in Manhattan on March 25, 2021.
People protesting against New York’s COVID-19 nursing home policy at a vigil in Manhattan on March 25, 2021.
Photo by Spencer Platt/Getty Images

In this role, Zucker is responsible for overall planning, direction and management of global strategy and programs at the CDC.

It’s been three years, but New Yorkers have not forgotten, and thousands of families of deceased seniors will not stop demanding answers and accountability.

From Congress to local district attorneys, there are many authorities with the power to investigate his and the administration’s misdeeds to help bring closure.

(But don’t count on Gov. Kathy Hochul, who promised a report but still has yet to deliver.)  

At the least, the state could finally update its grossly inaccurate July 2020 DOH report.

And as for the disgraced Howard Zucker, he should be permanently tossed as far out of government as possible.

Lee Zeldin (R) represented Suffolk County in the House of Representatives from 2015-2023 and ran for governor of New York last year.

https://nypost.com/2023/08/01/feds-hired-ny-health-czar-who-defended-deadly-nursing-home-order/

Boehringer moves liposarcoma drug into pivotal trial

 Boehringer Ingelheim has started a registration trial of its experimental therapy brigimadlin as a treatment for dedifferentiated liposarcoma (DDLPS), a rare cancer with limited treatment options.

The orally-available MDM2-p53 agonist is designed to restore the function of p53, the most frequently mutated gene in cancer, which has so far resisted drug development efforts. The p53 gene itself is mutated in one-half of all cancers, while its signalling pathway is disrupted in the other half.

Brigimadlin (also known as BI 907828) is a small molecule that blocks the interaction between the p53 protein – which suppresses cancer by stimulating the expression of genes that are involved in DNA repair and programmed cell death – and MDM2, which inhibits its activity.

Advancing the compound into a phase 2/3 trial is a landmark moment for p53 as a drug target, with prior efforts to develop drugs that target mutant p53 held back by difficulties in finding a suitable binding site as well as delivering them to the nucleus of cells, where the protein is mainly located.

The BRIGHTLINE-1 study compares brigimadlin to chemotherapy with doxorubicin in patients with advanced, inoperable DDLPS, an aggressive tumour type that starts in fat cells and is characterised by amplification of the MDM2 gene.

At the moment, the only treatment option is chemotherapy, but this typically stops working in a few months and has a lot of side effects. Five-year survival for advanced DDLPS patients is low, coming in somewhere between 20% and 44%.

In early-stage clinical testing, brigimadlin was shown to slow the growth of DDLPS as well as other p53-mutated solid tumours, both alone and in combination with Boehringer's experimental PD-1 inhibitor ezabenlimab (BI 754091).

Boehringer announced the start of the pivotal trial in its interim update today, in which it also said it had accelerated the clinical development of two other cancer therapies – HER2-directed tyrosine kinase inhibitor zongertinib (BI 1810631) and DLL3/CD3 bispecific T-cell engager BI 764532 – after "positive early…data."

Outside oncology, the German pharma also said it had moved PDE 4B inhibitor BI 1015550 into two phase 3 trials in idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis. Boehringer is already a big player in IPF with its Ofev (nintedanib) therapy.

In its update, Boehringer said currency-adjusted net sales rose by 9.7% to €12.2 billion ($13.4 billion), led by growth for Eli Lilly-partnered diabetes and heart failure and chronic kidney disease therapy Jardiance (empagliflozin).

https://pharmaphorum.com/news/boehringer-moves-liposarcoma-drug-pivotal-trial

EQRx's low-price drugs mission ends with Revolution buy

 EQRx's pledge to disrupt the pharma pricing system started with a clarion call in 2020 but ended with a whimper today with an agreement to be taken over by Revolution Medicines.

Revolution and EQRx both emerged from the stable of former Third Rock Ventures partner and serial biotech company founder Alexis Borisy, and the merger will see around $1 billion added to Revolution's capital reserves that will help it to advance its pipeline of cancer therapies through the clinic.

EQRx's R&D programmes will be wound up and intellectual property rights returned to their original owners, with the combined company focusing all its efforts on three clinical-stage RAS(ON) inhibitors, RMC-6236, RMC-6291 and RMC-9805.

When it was formed, EQRx said it planned to bring a new PD-L1 checkpoint inhibitor to market, licensed from China's CStone Pharma, that would be priced at a substantial discount to the current therapies on the market, such as current market leader Keytruda (pembrolizumab) from MSD.

Its plans were thrown into disarray, however, when it became clear that the FDA was reluctant to approve drugs based purely on overseas data, a stance exemplified when the regulator blocked the approval of Eli Lilly's PD-1 inhibitor sintilimab – licensed from China's Innovent Biologics – last year.

As a result, EQRx hit the reset button, shedding more than half of its workforce, shedding partnerships and abandoning all its R&D programmes – including PD-L1 inhibitor sugemalimab. It said it would continue to develop one asset, a CDK 4/6 inhibitor called lerociclib, which had advanced into a phase 3 endometrial cancer trial, but that is now also shelved.

The $1 billion in cash that EQRx still holds will now be added to Revolution's healthy $900 million cash balance, giving the combined company plenty of financial resources to bring the RAS(ON) candidates through development.

Revolution said its plan now is to press ahead with the parallel development of all three drugs, with RMC-6236 – a multi-RAS inhibitor – due to start "one or more" pivotal trials as a monotherapy in 2024. Data from earlier studies in non-small cell lung cancer (NSCLC) and pancreatic cancer will be presented at the ESMO cancer congress in October.

There will also be an update in the coming months on KRAS G12C inhibitor RMC-6291, which would be a potential rival to Amgen's Lumakras (sotorasib) and Mirati's Krazati (adagrasib), already approved in the US for KRAS-mutated NSCLC. Finally, a trial of KRAS G12D inhibitor RMC-9805 is due to start shortly.

"This singular acquisition of a sizable quantum of capital signifies the growing confidence we have in our RAS-focused drug candidate pipeline and substantially increases our capacity to continue advancing high-performing oncology assets," commented Revolution's chief executive Mark Goldsmith.

Revolution said it expects the deal to close in November.

https://pharmaphorum.com/news/eqrxs-low-price-drugs-mission-ends-revolution-buy

US Loses Fitch AAA Rating; White House Says GOP Extremism 'Continued Threat' To Economy

 On Tuesday, Fitch downgraded the U.S. government’s top credit rating, a move that surprised investors and drew a strong response from the White House, despite the resolution of the debt ceiling crisis two months ago.

What Happened: Fitch downgraded the United States to AA+ from AAA, citing fiscal deterioration over the next three years and repeated down-the-wire debt ceiling negotiations that threaten the government's ability to pay its bills, Reuters reports.

This decision comes two months after the Democratic President Joe Biden and the Republican-controlled House of Representatives reached a debt ceiling agreement that lifted the government’s $31.4 trillion borrowing limit, ending months of political brinkmanship.

White House Press Secretary Karine Jean-Pierre said that the ratings model used by Fitch declined under President Donald Trump and then improved under Biden.

“It defies reality to downgrade the United States at a moment when President Biden has delivered the strongest recovery of any major economy in the world,” said Jean-Pierre on X, formerly Twitter.

The White House said in a statement that it strongly disagrees with this decision. Instead it blamed Republicans’ actions as a “continued threat” to the U.S. economy.

“President Biden has delivered the strongest recovery of any major economy in the world. And it's clear that extremism by Republican officials—from cheerleading default, to undermining governance and democracy, to seeking to extend deficit-busting tax giveaways for the wealthy and corporations—is a continued threat to our economy."

Why It Matters: Treasury Secretary Janet Yellen also disagreed with Fitch’s downgrade calling it “arbitrary and based on outdated data,” reported Reuters.

The downgrade is significant as it marks the second time a major rating agency has stripped the United States of its triple-A rating, the first being Standard & Poor's.

This decision reflects the ongoing concerns about the U.S. government’s fiscal management and the political standoffs over the debt limit, as earlier discussed on Benzinga.

The downgrade could potentially increase the financing costs for the U.S. government. However, some analysts, like Steven Ricchiuto, U.S. chief economist at Mizuho Securities USA, believe the impact of the downgrade will be limited.

Venture capitalist Chamath Palihapitiya has previously stated that credit rating downgrades may not significantly impact the economy, as reported by Benzinga. He noted that after the Standard & Poor’s downgrade in 2011, there was no significant impact on the economy.

https://www.benzinga.com/economics/macro-economic-events/23/08/33510518/us-loses-aaa-credit-rating-from-fitch-biden-white-house-says-republican-extremism

'EcoWarrior' plastic-free Barbie elaborate hoax by climate-change activists

 Amid this summer’s ongoing Barbie-mania came one product drop that actually stood out above the bright-pink cacophony: a line of MyCelia™ EcoWarrior Barbies, inspired by environmental activists including Greta Thunberg and Daryl Hannah, along with the unprecedented announcement that Mattel will stop using plastic completely by 2030.

“I am honored to join forces with Mattel in their visionary efforts to create a better world through play,” said actress and longtime activist Hannah in a news release seemingly issued by the toy company on Tuesday, as reported in outlets from the Washington Times (since removed) to People. “Barbie has changed in many ways since I was a girl, but under the surface, she’s still toxic. Now, when she’s done being used, instead of persisting forever as a poison Barbie will be able to return to the earth, just like all living things. I am thrilled to be a part of this exciting journey.”

Even further, noted the press release, the new Barbie line will soon expand to honor more than 2,500 global environmental activists who have died or been killed in the line of protecting nature in the last decade.

It was all pretty astonishing.

And you’d even be forgiven for finding the news unbelievable — since it was, in fact, a hoax, as shared exclusively with Yahoo Entertainment prior to Tuesday's announcement.

The trick came courtesy of longtime political pranksters the Yes Men, comprising Igor Vamos and Jacques Servin (better known as their activist alter egos, Mike Bonanno and Andy Bichlbaum), and Hannah herself, who starred in the fake commercial about the line of EcoWarrior Barbies and was scheduled to host a late-day press conference on Tuesday to reveal the hoax. Together, the activists decided to seize this Barbie-obsessed moment to sound the alarm on the climate crisis.

“This is probably the most successful PR coup of all time when it comes to people thinking that because there are surface changes in the doll that it’s changing some fundamental dynamic in our culture, which it’s not,” Vamos tells Yahoo of the Barbie movie, which he has not yet seen but plans to with his kids. “Barbie is still literally made out of oil by sweatshop workers. … But we’re caught up in identity politics and losing track of what’s happening, which is the planet is being destroyed right in front of us.”

He adds: "To say the doll is feminist now when the toy is contaminating the environment that the future of all humanity and all life depends on is kind of a colossal and bizarre joke."

A Mattel spokesperson told Yahoo regarding the press release: "This release has nothing to do with Mattel. It is not a product and it is fabricated. This is false and inaccurate information." Later, the spokesperson added, "It’s a hoax. Not sure if Ms. Hannah is really involved or not but this has nothing to do with Mattel."

The Yes Men have been using satirical performance art to raise awareness of harmful corporate behaviors — from unfair labor practices to the wreaking of environmental disasters — for over 20 years. In that time, they’ve skewered everyone from Dow Chemical and McDonald’s to Adidas and Starbucks.

And, long before this week, Mattel.

The fake EcoWarrior Barbies announcement was actually a reprise of a project called the Barbie Liberation Organization (BLO), which, back in 1993, saw Vamos and a team of activists pull off a major stunt in protest of the newly released Teen Talk Barbie, which said, among other objectionably sexist phrases, "Math is hard." In response, the underground team purchased hundreds of the Barbies, along with the same amount of talking G.I. Joe dolls; they then switched the voice boxes and put all the toys back on shelves, with the military doll saying things like "Let’s go shopping!" and Barbie uttering, "Vengeance is mine!" It prompted a flurry of gobsmacked media coverage.

Fast-forward to today, when Barbie might finally have the feminist part right thanks to frequent rebrands and fresh help from Greta Gerwig’s anti-patriarchy lens, but the plastic problem remains, says Hannah.

"I feel like they’re separate issues," the Splash star, who has not seen Barbie but has been arrested over the years for protesting issues from the Keystone XL pipeline to the razing of an urban farm in Los Angeles, tells Yahoo.

"I think it's a great thing, actually, that Mattel is trying to join the modern world, and that they're taking this sort of brave step to focus on changing that narrative of ‘math is hard’ … They took a big chance with a brand that's very important to them," she continues. "But nevertheless, they are a multi-billion-dollar corporation. They have the means to be able to make an impact. They're one of the largest toy companies in the world and toys don't need to be made of something that poisons children, literally, and that gets into our bodies, into our systems, into our landfills, into our waterways, into every part of our life support systems."

Because the company has the means, she adds, "they have the power to be able to say, ‘Not only are we going to change what our brand stands for in terms of the messages [about] body image and self-esteem and feminism, but also, like, the basics of just what the product is made out of."

Hijinks as activism

So why have the Yes Men decided that trickery is the way to make bold statements?

"In one word: fun," Vamos, also a media-arts professor, says. "It’s not the best way to do activism, but it's a way that works for a lot of people, and people like to share things that are fun, so it's highly shareable. And … especially in dire times, it helps to be able to have a laugh while you’re trying to make a difference."

Finding the perfect target, he says, is sometimes a matter of something just "leaping out at you" (as in "math is hard"), while other times it's about "fitting into a campaign that already exists, like the U.S. Chamber of Commerce being part of climate-change denial movement," which Yes Men seized upon in 2009.

In this latest case, Vamos and Servin were working with Hannah on a documentary about the original 1993 BLO stunt when Hannah suggested it was a good time to target Barbie once again.

Even though they are impersonating corporations with their hoaxes, the Yes Men have surprisingly been sued only once, by the U.S. Chamber of Commerce, which wound up dropping the legal action.

"We want to be sued, we welcome it, and that maybe makes them fear us a little bit, because that would be an opportunity to hold them accountable in the court of public opinion," says Vamos. "Going into court when you have the moral high ground, you may not win, … but at least you can make your point along the way." With their spotlighting of Adidas over Cambodian working conditions, for example, "it was clear who's in the right and in the wrong, so if they decided to sue over satire, even if they won, we would get to talk about them, and it would amplify the story."

Also, he stresses, "We aren't breaking the law."

But what's wrong with Barbie?

According to the non-profit global alliance Plastic Pollution Coalition, "Barbie (and all of her plastic 'friends' and accessories) are made with at least five types of fossil fuel-based plastics: polyvinyl chloride (PVC), ethylene vinyl acetate (EVA), acrylonitrile butadiene styrene (ABS), and hard vinyl — plus additive chemicals," some linked to "asthma, metabolic disorders, obesity, and other health problems."

And then there's her footprint. "Plastic’s endless and toxic existence fuels serious pollution of our air, land, fresh water, ocean and bodies. This pollution starts when the fossil fuel ingredients used to make plastics are extracted from the Earth and continues on into plastics and chemical production, storage, transportation, and manufacturing. Plastics carry on polluting throughout their use and eventual toxic 'disposal' in landfills, incinerators, or the environment," says the coalition.

Even before Gerwig's movie, nearly 60 million Barbies were sold globally, equivalent to more than 100 sold every minute, "contributing emissions equivalent to burning 381 million gallons of gasoline," noted a recent analysis of toys in the Yale Environment Review.

"It's bigger than Mattel, but it's a good place to start because of all the attention that's on them now, and also because they could lead," says Hannah, pointing to a recent announcement about a shift in materials — something Mattel stressed to Yahoo on Tuesday, saying, "We have long-ago announced our sustainability goals, most notably to achieve 100% recycled, recycled or bio-based plastic materials by 2030 which can be found here."

But unfortunately, Hannah says, "there just is no such thing" as recycling, stressing that "we have to face that the petrochemical industry has promoted recycling because it alleviates their guilt around the fact that it is all going to the landfill. … It was all kind of a scam to make people feel better about using disposable plastics."

Indeed, major environmental organizations including Greenpeace have declared recycling to be "a dead-end street," and extensive reporting has called it out as a "myth."

Says Vamos on recycling: "All it means is that you’re using things that have been used before, but it’s still plastic waste. It just kicks the can down the road a little bit. It doesn’t solve the problem at all."

Instead, stresses the campaign, companies must stop making harmful products in the first place — Vamos believes a "wartime approach," such as when the U.S. shut down car production during World War II in favor of focusing all resources on the war effort, is what's called for.

To that end, a centerpiece of the BLO's prank was that Barbies would now be made out of 100% biodegradable matter — like mushroom mycelium (used more and more in shoes and bags as a vegan alternative to leather), algae and seaweed.

Is that even possible?

Yes, Vamos claims, though "it would take a tremendous effort to get up to scale," and it would be expensive. "But what better time than now, when their stock price went up and they’re in the position to actually do it?"

Jokes aside, Hannah says there is no choice but to dig deep to find hope and join the effort to force change.

"The easiest and most basic thing to do is stop doing damage. Do I have hope that we will do it? All I know is that you can be nihilistic about it, or you can keep fighting for people to wake up and do something. And I think you really don't have a choice, you know? It's like … do I commit suicide or do I just keep trying to make my life better?"

As far as the upshot of this week's hoax, Hannah says, "I really do hope that Mattel takes this as a hint of what their next step should be and that they should do it as soon as humanly possible, because there are ways of making things out of other materials that already exist. It would be great if they would say: 'You know, that's a great idea. We might as well be the world's leaders in this and be the first and show the way forward.' It would be beautiful."

https://www.yahoo.com/entertainment/daryl-hannah-ecowarrior-plastic-free-barbie-hoax-climate-change-activists-exclusive-210816420.html