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Thursday, January 4, 2024

Prescription drugs sold online without 'robust' checks

 Patients' lives are being put at risk because it is too easy to buy prescription-only medicines from online pharmacies, a leading pharmacist says.

A BBC investigation found 20 online pharmacies selling restricted drugs without checks - such as GP approval.

In total, we bought over 1,600 various prescription-only pills by entering false information without challenge.

Regulator the General Pharmaceutical Council says extra checks are needed when selling some drugs online.

The BBC's findings highlight the "wild west" of buying medicines on the web, says Thorrun Govind, a pharmacist, health lawyer and former chair of the Royal Pharmaceutical Society.

"The current guidance basically tells pharmacies to be robust, but do that in your own way, and we know that under this current system, patients have died," she says.

The parents of a woman who died in 2020, after accidentally overdosing on medicines she bought online, are among those calling for stricter rules.

Katie Corrigan, from St Erth in Cornwall, had developed an addiction to painkillers after experiencing neck pain.

"Katie needed help, she didn't need more medication," says her mum, Christine Taylor.

Her GP had stopped supplying the drug after realising she had been allowed to request new prescriptions prematurely and been prescribed too much.

Instead, Katie, 38, was able to buy a painkiller and a drug used to treat anxiety from multiple online pharmacies without notifying her GP.

The coroner at Katie's inquest confirmed her GP had not been contacted by any of the pharmacies to check the drug was safe for her. In his final report, he said the safety controls were inadequate.

Christine wants online pharmacies to obtain more background information. "It's far too easy - it's people's lives, and it's a disaster waiting to happen," she says.

Undercover experiment

Current guidance from the regulator, the General Pharmaceutical Council, (GPhC) says online prescribers must get "all the information they need" to ensure a medicine is safe and appropriate for an individual patient.

It also states that "high-risk, habit-forming medicines", like those Katie Corrigan was able to buy, should not be sold online without additional safeguards.

But some of the medicines she bought still appear to be readily available from some online pharmacies, the BBC has found.

Some of the drugs the BBC reporter managed to buy during the investigation
The BBC bought three restricted drugs online as part of the investigation

We attempted to buy prescription-only drugs from regulated online pharmacies.

We selected three restricted drugs - including an anti-anxiety drug, a painkiller and a sleeping medication. We are not naming these drugs because they can be dangerous when taken without medical guidance.

Of the 20 businesses we identified selling one or more restricted drugs:

  • We found nine pharmacies selling the anti-anxiety drug
  • Three pharmacies sold the anti-anxiety medicine to us on the basis of our answers to an online questionnaire and did not require further checks
  • In total, we were able to buy a potentially fatal dose of the anti-anxiety medicine
  • We bought the painkiller from nine pharmacies based on online questionnaires
  • We similarly obtained the sleeping medication from 14 pharmacies

But 13 online pharmacies which sold at least one of these drugs refused to sell to us without access to some medical records, proof that we had been prescribed them before by a doctor, or permission to contact our GP to carry out further safety checks.

Two pharmacies refunded our order after assessing our answers to the questionnaire.

We also found evidence of high-risk and potentially addictive medicines, including benzodiazepines and antidepressants, being sold on the basis of online questionnaires.

One online pharmacy sent a marketing email telling us we had "something fabulous" in our basket and to "buy before time runs out", referring to an addictive painkiller. This is language the regulator, which can disqualify a pharmacist from its register, says should not be used.

Five of the pharmacies that sold to us sent follow-up emails with more safety information and contact details if we had concerns or needed to ask any questions.

Every pharmacy that sold to us had a disclaimer urging us to alert our GP about the purchase.

'Vague guidance'

The BBC spoke to several other people who said they have been able to circumvent safety checks to buy medicines from online pharmacies.

One woman, who wanted to remain anonymous, said she bought a prescription-only weight loss drug in July by falsely claiming to be roughly double her real weight in a questionnaire.

The woman said she was asked to verify her identity by showing an image of her driving licence, but was not asked to provide any evidence of her weight.

There were no further checks to ensure the drug was suitable before it was dispatched.

"After taking it for a few days, I felt really bad - I couldn't eat, I was exhausted and basically stopped functioning," she said.

"If I'd had to send a picture, or any proof of my weight, I don't think I would have been prescribed it."

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If you are affected by any of the issues raised in this story you can contact BBC Action Line here.

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Unlike illegitimate, black market sellers, licensed online pharmacies are regulated by the GPhC and employ qualified pharmacists and prescribers.

They are expected to carry out risk assessments to determine which medicines can be safely sold online, and the regulator can take action if they are deemed to be practising dangerously.

But Ms Gorrund says the guidance from the regulator is too vague, and does not state clearly enough what checks online pharmacies should be conducting.

"This has led to such a variation, with some online pharmacies asking for checks like video consultations, while others seem to let you simply click on the drug you want and go forward to pay," she explains.

Thorrun Govind
Thorrun Govind says the guidance from the regulator, the GPhC, is too vague

The Royal Pharmaceutical Society says the findings are "concerning", and it wants to see regulators take action where poor professional practice has been highlighted.

The GPhC issued renewed guidance in 2022 after it found hundreds of its investigations into whether pharmacies should be allowed to continue operating related specifically to online pharmacies.

In a statement, it told the BBC it expected pharmacy owners to carry out risk assessments to identify which medicines are safe to supply online and identify requests for medicines that are too large or too frequent.

A spokesperson said: "We have made it clear that medicines liable to abuse, overuse or misuse, such as opioids and sedatives, should not be sold online unless further safeguards have been put in place.

"We have taken regulatory action against online pharmacies which fell short of professional standards, including in some cases where 'high-risk, habit-forming' medicines were supplied on the basis of an online questionnaire."

https://www.bbc.com/news/health-67714023

France detects bird flu on vaccinated ducks farm

France has detected bird flu on a duck farm in the Vendee region in the west of the country, the farm ministry said on its website, the first such outbreak since France started vaccinating against the virus last year.

The Vendee prefecture said highly pathogenic avian influenza, commonly called bird flu, had been detected on Tuesday on a farm with 8,700 ducks in the town of Notre Dame de Riez. All of them had been vaccinated, it said.

Bird flu, which is carried by migrating wild birds and can then be transmitted between farms, has ravaged flocks around the globe in recent years, disrupting supply, pushing up food prices and raising concern of a risk of human transmission.

To protect itself, France launched a vaccination campaign early last October, targeting ducks only as they can easily transmit the virus without showing symptoms.

The vaccine is not supposed to fully protect birds from catching the disease but to limit its spread and thus avoid massive preventive culls. It comes in addition to standard biosecurity and control measures.

France is the first large exporter to vaccinate poultry against bird flu, braving trade barriers from countries that fear the virus could spread without being noticed.

France had raised the risk level of bird flu to 'high' from 'moderate' last month after new cases of the disease were detected, forcing poultry farms to keep birds indoors to stem the spread of the highly contagious virus.

So far seven bird flu outbreaks have been detected in France since Nov. 27, the agriculture ministry said on its website, of which five on turkeys, one on laying hens and one on ducks.

https://uk.news.yahoo.com/france-detects-bird-flu-vaccinated-142624601.html

Putin offers citizenship to foreigners who fight for Russia

 Russian President Vladimir Putin approved an order that will grant citizenship to foreigners who fight against Ukraine.

According to the decree, foreign nationals who serve with the Russian military for at least one year will be eligible to receive citizenship for both themselves and their families.

The Kremlin extended the offer to "foreign citizens who signed a [one-year] contract with the Russian Armed Forces or military formations or who are undergoing military service during the special military operation [in Ukraine]," according to a translation from the Moscow Times.


Russian President Vladimir Putin sitting
Russian President Vladimir Putin attends a meeting with the president of the United Arab Emirates in Abu Dhabi.

Citizenship benefits would extend to those who served, their spouses, parents and children.

The decisions show foreign support for Russia's invasion of Ukraine has become an increasing priority for the government.


At least 315,000 Russian troops have been killed or injured so far in the war in Ukraine, amounting to nearly 90% of its personnel when the conflict started, a December 2023 report claimed.


Russian passport
An employee adjusts blank Russian passports at a Goznak factory in Moscow.

The statistic was highlighted in a declassified U.S. intelligence report that found Russia began its invasion of Ukraine in February 2022 with 360,000 troops, a source familiar with the document told Reuters at the time.

The report also said Russia started the war with 3,100 tanks but has since lost 2,200 of them, and after backfilling its army with T-62 tanks produced in the 1970s, it only has about 1,300 tanks on the battlefield, according to Reuters, citing the source.

Global intelligence reports have shown extensive efforts by Russian agents to field combatants in the conflict from foreign countries.

The Cuban government said last year it had uncovered a human trafficking network being operated in Russia with the goal of recruiting citizens to participate in the war against Ukraine.

Cuba's Ministry of Foreign Affairs said in a statement at the time that the country's ministry of the interior uncovered the operation, which it says has been dismantled.

The country's foreign affairs ministry said the country has a "firm and clear historical position against mercenarism, and it plays an active role in the United Nations in rejection of the aforementioned practice, being the author of several of the initiatives approved in that forum."

https://news.yahoo.com/putin-offers-citizenship-foreigners-fight-154427415.html

Trump meets Teamsters chief as union weighs presidential race

 Donald Trump met with the head of the Teamsters on Wednesday and made plans to meet with rank-and-file members later this month as he seeks the 2024 Republican presidential nomination, the former president and the union said in statements.

Sean O'Brien, president of the International Brotherhood of Teamsters, and Trump had "an in-depth and productive discussion on worker issues most important to the Teamsters Union," the labor group, which represents 1.3 million workers from truckers and police to nurses and film crews, said in a post on the X social media platform.

The meeting comes during a 2024 presidential campaign in which the economy is front and center, with unions seeking to capitalize on the historic shift in the U.S. labor market and securing a wave of recent labor deals with support from Democratic President Joe Biden's administration.

Biden, who quashed Trump's reelection bid in 2020 and has touted his union bona fides for decades, is likely to face Trump again in the November election if the Republican frontrunner secures his party's nomination.

"There are serious issues that need to addressed to improve the lives of working people across the country, and the Teamsters Union is making sure our members’ voices are heard as we head into a critical election year,” O’Brien said in the statement on Wednesday night.

Trump, in a post on his Truth Social platform, called the dinner meeting "great," adding, "Looking forward to more discussions about important issues in the near future!"

He also pledged to meet with union workers and other Teamsters officials at a January roundtable in Washington, the union said.

O'Brien, a self-described tough "SOB," is part of a new generation of union leaders - including United Auto Workers (UAW) President Shawn Fain and Association of Flight Attendants-CWA President Sara Nelson - seeking to re-energize the fight for workers' rights. Union members at Detroit's Big Three automakers, major airline carrier pilots and UPS have all recently secured labor contracts with hefty pay increases and job protections.

Their endorsements could be crucial in a presidential race among a closely divided electorate where just a few thousand votes in several key states could have an outsized impact.

In the past, Trump has found support among blue-collar workers, particularly in conservative areas.

Like the Teamsters, the UAW has not yet endorsed a candidate. That union's president, however, has been critical of Trump and invited Biden to a strike picket line last fall before winning record agreements with General Motors, Ford and Chrysler parent Stellantis. Trump did not visit a union picket line but did deliver a speech outside Detroit urging autoworkers to support him.

Government employee unions have also pushed back on Trump's proposal to strip federal worker protections as part of his plan to gut the civil service and install loyalists.

https://news.yahoo.com/teamsters-chief-trump-meet-union-150323935.html

Consumer Reports finds 'widespread' presence of plastics in food

 Consumer Reports has found that plastics retain a "widespread" presence in food despite the health risks, and called on regulators to reassess the safety of plastics that come into contact with food during production.

The non-profit consumer group said on Thursday that 84 out of 85 supermarket foods and fast foods it recently tested contained "plasticizers" known as phthalates, a chemical used to make plastic more durable.

It also said 79% of food samples in its study contained bisphenol A (BPA), another chemical found in plastic, and other bisphenols, though levels were lower than in tests done in 2009.

Consumer Reports said none of the phthalate levels it found exceeded limits set by U.S. and European regulators.

It also said there was no level of phthalates that scientists confirm is safe, but that does not guarantee the safety of foods you eat.

Phthalates and bisphenols can disrupt the production and regulation of estrogen and other hormones, potentially boosting the risk of birth defects, cancer, diabetes, infertility, neurodevelopmental disorders, obesity and other health problems.

Among tested supermarket foods, Annie's Organic Cheesy Ravioli contained the most phthalates in nanograms per serving, 53,579, followed by Del Monte sliced peaches and Chicken of the Sea pink salmon.

Elevated phthalate levels were also found in products such as Cheerios, Gerber baby food and Yoplait yogurt, and several burgers, nuggets and fries from Wendy's, Burger King and McDonald's.

Consumer Reports also found variations among similar products. The 33,980 phthalates in nanograms per serving in Wendy's Crispy Chicken Nuggets, for example, was more than four times the level in McDonald's Chicken McNuggets.

"That tells us that, as widespread as these chemicals are, there are ways to reduce how much is in our foods," said James Rogers, who oversees Consumer Reports' product safety testing.

The consumer group said a reassessment by the U.S. Food and Drug Administration and other agencies of the risks of plasticizers is "overdue and essential."

Polar raspberry lime seltzer was the only tested product containing no phthalates.

General Mills, whose brands include Annie's, Cheerios and Yoplait, did not immediately respond to requests for comment. Burger King and Wendy's did not immediately respond to similar requests.

Chicken of the Sea and Del Monte said they do not add phthalates to their food, and receive similar assurances from their suppliers. Del Monte also said that phthalates are "widespread in the environment."

Gerber and McDonald's said they follow regulatory requirements, and require rigorous testing for chemicals in packaging.

https://news.yahoo.com/consumer-reports-finds-widespread-presence-110515746.html

Silo Pharma Concludes First Phase of Dose-Ranging Study Of Intranasal Treatment For PTSD

 Thursday, Silo Pharma Inc 

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 provided an update on its previously announced dose-ranging study of SPC-15, a targeted prophylactic treatment for post-traumatic stress disorder (PTSD). 

In November, Silo Pharma announced a new exclusive license agreement with Medspray Pharma BV for its proprietary patented soft mist nasal spray technology, the delivery mechanism selected for Silo's intranasal therapeutic drug SPC-15.

The study aims to identify the maximum tolerated intranasal dose of the drug and pharmacokinetic in small animals to determine the therapeutically relevant dose range.

The six-to eight-week non-GLP study includes a single ascending dose evaluation (phase 1) and a 7-day repeat intranasal dose toxicity and pharmacokinetic study. 

In the first phase of the study, all of the animals appeared to tolerate the intranasal dosing procedure well, with minimal struggling and no sneezing observed. 

The final validation report is expected in the first quarter of 2024. 

Eric Weisblum, Chief Executive Officer of Silo Pharma, commented, "There have been no adverse clinical observations reported to date for this study, which began in late November 2023 and will conclude in the first quarter of 2024. If successful, this non-GLP study will be followed by a GLP safety and toxicology study, both of which will be utilized in connection with filing an expected Investigational New Drug (IND) application with the FDA." 

Preclinical data has shown that SPC-15 has additive benefits for combating stress-induced pathophysiology at the behavioral and neural levels. 

https://www.benzinga.com/general/biotech/24/01/36485690/silo-pharma-concludes-first-phase-of-dose-ranging-study-of-intranasal-treatment-for-post-traumati