Pfizer's (PFE) recent buyout, Seagen (SGEN), has lost a patent dispute with Daiichi Sankyo (DSKYF) with AstraZeneca (AZN).
https://seekingalpha.com/news/4055534-pfizer-loses-enhertu-patent-dispute-daiichi
Wednesday, January 17, 2024
Arcus Phase 1b Study Promising Overall Survival in Pancreatic Cancer
- Median Overall Survival was 15.7 months for all patients treated with 100 mg quemliclustat-based regimens in the ARC-8 study, which exceeds the historical benchmark data for chemotherapy alone
- A 37% reduction in risk of death and a 5.9-month improvement in median overall survival was observed for patients treated with quemliclustat-based regimens when compared to a Synthetic Control Arm® (SCA®) of patients treated with chemotherapy alone in a post-hoc analysis
- Detailed results will be presented at the ASCO Gastrointestinal Cancers Symposium on January 19 from 12:30 – 2:00pm PT / 3:30 – 5:00pm ET
Leap to present on Phase 2 study at ASCO
30% ORR and 93% DCR across heterogenous second-line CRC patients
treated with DKN-01 plus bevacizumab and chemotherapy
Subgroup analysis reveals greatest benefit in left-sided tumors, particularly rectal and rectosigmoid patients with
46% ORR, 100% DCR, and preliminary median PFS of 9.4 months.
Leap to host conference call to report additional clinical data including further subgroup analyses
on Tuesday, January 23, 2024 at 8:30 a.m. ET
Leap's management team, together with Dr. Pelster and Dr. Wainberg, will host a conference call on Tuesday, January 23, 2024 at 8:30 a.m. Eastern Time to further discuss the data. The conference call will be broadcast live in listen-only mode and can be accessed via the website URL: https://edge.media-server.com/mmc/p/q5zrz568. A replay of the event will also be available for a limited time on the Investors page of the Company's website at https://investors.leaptx.com/.
Acurx: 'Positive Partial Comparative Data' for Ibezapolstat from Phase 2b C. diff. Trial
- Ibezapolstat outperformed vancomycin showing eradication of fecal C. difficile at Day 3 of treatment in 15 of 16 treated patients (94%), versus vancomycin which had eradication of C. difficile in 10 of 14 treated patients (71%).
- Ibezapolstat, but not vancomycin, consistently preserved and allowed regrowth of key gut bacterial species believed to confer health benefits including to prevent recurrence of CDI
- Further analyses will be forthcoming Q1 2024, as data become available, regarding other endpoints from the Phase 2b trial, including Extended Clinical Cure (ECC) data up to 94 days
- Preparation underway for meetings with FDA, European Medicines Agency and other global regulatory agencies and advancement to international Phase 3 clinical trials
- Ibezapolstat has previously received FDA QIDP and Fast-Track Designation
'Grabbing $300 billion of Russian assets is no panacea, West cautions in Davos'
Western officials said in Davos on Wednesday they were open to the idea of confiscating $300 billion of Russian assets to help Ukraine, but cautioned that the devil was in the legal detail and that, even if it could be done, it would be no panacea for Kyiv.
After President Vladimir Putin sent troops into Ukraine in 2022, the United States and its allies prohibited transactions with Russia's central bank and finance ministry, blocking around $300 billion of sovereign Russian assets in the West.
G7 countries are discussing possibly confiscating the frozen Russian assets, though some G7 members have concerns about the precedent, mechanism and potential impact of taking such a step against central bank assets.
"The first thing you know is a ton of lawyers need to get involved. No decisions been made," Penny Pritzker, U.S. special representative for Ukraine's economic recovery, told a panel on Monday.
"If a decision gets made it's going to end up being collective. It's a misperception to think this is going to be a panacea effect. There's real effort going on but we are far from a conclusion."
Russia, which was not represented at Davos, has warned that confiscation of those assets would go against the principles of free markets and the Kremlin has warned it would seize U.S., European and other assets in response to such a move.
CLEAR MECHANISM NEEDED
U.S. Treasury Secretary Janet Yellen last year expressed concerns about significant legal obstacles to confiscating frozen Russian assets, but more recently has embraced exploring the idea in a tighter funding environment.
'#TikTokMadeMeBuyIt: Stanley unleashed 'perfect storm' of viral marketing for Quencher mugs'
A major marketing expert claimed that Stanley unleashed a "perfect storm" of viral marketing with social media monolith TikTok to get consumers crazy for its 40 oz. Quencher mugs.
Victor Lee, the president of marketing consulting group Advantage Unified Commerce, recently spoke to Fox News Digital about how the company used the social media platform to snag the attention of millions of Americans and get them to buy its tumbler – dubbed the "Stanley Cup" by fans.
The strategy netted the company ten times its usual annual profits in just a short period of time and made legions of consumer ravenous for the product.
Woodland Hills, CA - January 09: A few 40oz. 'Quenchers', the Stanley insulated steel tumblers, remain at a Target store on Tuesday, Jan. 9, 2024 in Woodland Hills, CA. (Brian van der Brug / Los Angeles Times via Getty Images / Getty Images)
The expert called Stanley’s entrance into the viral marketing space "brilliant," especially for being able to take something as innocuous as a water bottle and turn it into a must-have product.
The Stanley Cup craze has been in overdrive in recent months, evidenced in viral videos showing consumers buying up store shelves of the product within minutes, and weeping for joy after getting them for Christmas. The craze has become so prevalent that headlines have been made about parents telling bullies to lay off their kids for not having an official Stanley tumbler.
Lee began by discussing the current social media landscape and how the tumbler company was able to use it to its advantage. The expert mentioned how the current way to win the social media race is by doing the best at leveraging the attention of the platform users for the company or influencer’s benefit.
"Your phone is now saying, ‘if I have five minutes to your attention, where do you want to go?’ And wherever you tap to, that's who wins," he said. "And if they don't give you enough good stuff to occupy five minutes, you know you're shutting that app off or that site off, and you're going to another button, and you're hitting it. That's the race."
He noted, "Who wins the race is what they did with your attention. And I think this is where TikTok fell into" Stanley’s plans.
The expert further detailed how TikTok, compared to other social media platforms, is best equipped to trigger audiences into a reaction, including buying products. Providing an example, he said, "TikTok is very well known for, ‘I'm going to throw a random challenge. Go do it. Go run and jump into that swimming pool. Go hop the fence or do this.’ And there's a lot of other controversial stuff."
He also referenced the growing "#TikTokMadeMeBuyIt" trend that’s been sweeping the platform. The hashtag currently boasts 86.6 billion views and counting on all videos related to it. The trend involves users showing off the products they’ve bought while scrolling the app, which seems to drive more marketing and sales for the products depicted.
This almost compulsive virality combined with product placement means "now there's real business implications" for these social media platforms, Lee said, before adding that Stanley taking advantage of this dynamic "was the perfect storm."
"I would say they absolutely defined a moment of time and succeeded in it," the expert declared.
Explaining how the company did this specifically, Lee noted that Stanley relied on a mixture of factors, including TikTok’s platform, and Stanley’s knowledge of its audience.
He said, "It's not all luck, it’s not all strategy. It’s a fine mix of it. But it's also a conviction of knowing where an audience is, in this case social media and TikTok specifically, and then allowing multiple adjacencies."
Providing examples, he continued, "Like you started innovative with an influencer, if you want to call it innovative, then you went into TikTok. Suddenly it's like, ‘Well, what's the other adjacency? Well, is this audience also a Target audience? More Target than probably other retailers? Are they a Starbucks audience? More Starbucks than other coffee? Let's go there.’"
Stanley marketed its cups with both Target and Starbucks. The Target exclusive Stanley Quencher made news after viral video showed customers at a Target in El Paso allegedly buying up the store’s entire stock within minutes. Lee said the brand partnership itself was a "traditional" strategy rather than "innovative" on its own, but then combined with the design of cups and TikTok marketing, that’s where it become innovative.
He said, "But they struck it where it is innovative. It is the big Stanley Cup, giant one. It is colored. It is exclusive. It is that. So that's their innovation, which fits."
Shoppers rush to grab Stanley Valentine's cups at Target
Target shoppers run to get their hands on a special Valentine's Day edition of a special 40-ounce Stanley tumbler in Arizona. (Credit: @victoria_robino_26/LIFESTYLOGY /TMX)
Continuing, Lee discussed how social media, particularly TikTok, has been utilized by Stanley and other companies to generate a connection between the consumer and the product they see on their favorite influencers' channels for example.
Mentioning his experience as the head of Hasbro’s digital marketing, he said, "During that time the craze in our world was the unboxing of toys. Why would a five-year-old kid watch an hour of YouTube of somebody opening up a toy? And what we found out is there's a psychological effect of surprise, ‘I have something, and it's open,’ and there's a connection to like, Christmas, of opening something up. And that to them just captured their attention."
He added that TikTok presents the current form of that. "Now you fast-forward it six, ten years later. What is that? Well, there's entertainment value – TikTok is a massive entertainment value of that."
Lee added that TikTok is having a "double effect" on users. "Were we interesting? And did you do something? And I think that's the magic intersection that people aren't talking a lot about," he said.
Noting how marketing products benefits from this connection established between users and social media, he said, "Social media was always passive. I get to watch something, I get to engage, I get to feel that if there's a celebrity involved, that I am closer to them than if I see them in their natural environment, on TV or in a movie. And social allows me a glimpse of their real life. Now, if I happened to start buying something from them, it makes me a tighter connection."
"Because social feels more intimate and I'm closer to you – and if I trust you – it's a perfect storm, is what’s happening."
Guggenheim’s Walsh Says She’s Very Worried About Regional Banks
Regional banks are facing risks that will limit their lending ability, according to the chief investment officer of Guggenheim Partners Investment Management.
“I’m very concerned about the regional banks,” Anne Walsh said in a Bloomberg Television interview at the World Economic Forum in Davos. “They’ve got several risks happening at this point in time. They’ve got commercial real estate and a refinancing wall in that space and a refinancing wall in their commercial and industrial loans”
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