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Thursday, March 7, 2024

'An Oprah Special: Shame, Blame and the Weight Loss Revolution' Monday, March 18'

Oprah Winfrey hosts a sit-down conversation around the radical impact of prescription weight loss medications in the primetime event, "An Oprah Special: Shame, Blame and the Weight Loss Revolution," airing MONDAY, MARCH 18 (8:00-9:00 p.m. EDT), on ABC and the next day on Hulu. The special delves into the prevailing questions and concerns surrounding the impact on our health care, economy, lifestyle and culture. Speaking in front of a live studio audience, Oprah gathers the country's leading medical experts and everyday people who are in the battle of one of the biggest health care crises the world has ever known. For the first time in history, new drugs could prove to be the game changer to stem the tide of people living with obesity, an epidemic which has grown exponentially since the 1970s, costing $173 billion per year in medical costs in the United States alone.

"It is a very personal topic for me and for the hundreds of millions of people impacted around the globe who have for years struggled with weight and obesity," said Oprah Winfrey. "This special will bring together medical experts, leaders in the space and people in the day-to-day struggle to talk about health equity and obesity with the intention to ultimately release the shame, judgment and stigma surrounding weight." 

"We are thrilled to work with Oprah and the voices she has assembled to open a dialogue that destigmatizes and educates viewers on the important and polarizing topic of weight loss," said Craig Erwich, president of Disney Television Group. "I can think of no one better to lead this meaningful conversation about such a critical issue that touches all of our lives."

Joining the conversation are medical experts including Cleveland Clinic's Dr. W. Scott Butsch, ABC News chief medical correspondent Dr. Jennifer Ashton, ABC News medical correspondent Dr. Darien Sutton, Cedars-Sinai Medical Center's Dr. Amanda Velazquez and patients from around the country who have a range of personal experiences with prescription weight loss medications, including a teenager who was among the first to take the new drugs and begs the question whether these medications should be given to minors. Oprah also invites leaders from the two global pharmaceutical companies behind these revolutionary drugs to address what this means for the 100 million Americans and over 1 billion adults worldwide living with a deadly disease.

Key questions are addressed: Why is obesity designated a disease? Who are the medications really intended for? Who is eligible to receive weight loss drugs? What should folks ask their doctors? What are the short-term and long-term side-effects? What are the supply chain challenges and the impact on those with diabetes? Why is there shame surrounding taking medication, and what is the future of these medicines in our society and culture?

"An Oprah Special: Shame, Blame and the Weight Loss Revolution" is produced by Harpo Productions, executive produced by Oprah Winfrey and Tara Montgomery.

https://abc.com/collection/coming-soon/news/watch-an-oprah-special-shame-blame-and-the-weight-loss-revolution-on-abc-hulu

Transgender Healthcare Group Pushed Pseudoscientific Sex Change Experiments

 by Debra Heine via American Greatness,

Newly leaked files from a leading transgender “healthcare” organization show that doctors are aware that children and adolescents do not always comprehend and thus cannot consent to the hormonal and surgical transitions they champion. They also admit privately that the experimental procedures often have devastating and permanent side effects, including cancer and sterility.

The files from the World Professional Association for Transgender Health (WPATH) were obtained by journalist Michael Shellenberger, who posted the entire cache online. They include conversations from a WPATH internal messaging board and video from an Identity Evolution Workshop.

The internal communications suggest that the organization is controlled by gender ideologues who routinely conduct experimental hormonal and surgical procedures on minors and vulnerable adults despite legitimate medical and ethical concerns.

These shocking findings come after members of WPATH were credibly accused in the media of “rubbing shoulders with pedophiles and fetishists.”

After a months long investigation in 2022, the news and opinion website Reduxx found that WPATH was involved with a fetish forum that hosts and produces fictional child pornography and extreme sadomasochistic content, including graphic child sexual torture fantasies.

Despite serious concerns about the radical organization, the National Institutes of Health, the World Health Organization and every major American medical and psychiatric association all turn to WPATH for guidelines on how to treat gender-confused youth, the New York Post reported.

A number of doctors in the group admitted that their patients often did not understand the ramifications of hormone treatment or surgery – such as developing facial hair, the files showed.

A child psychologist said in a leaked email:

“[It is] out of their developmental range to understand the extent to which some of these medical interventions are impacting them.

“They’ll say they understand, but then they’ll say something else that makes you think, oh, they didn’t really understand that they are going to have facial hair.”

During a May 2022 internal workshop titled “Identity Evolution,” Daniel Metzger, a British Columbia endocrinologist said, “I think the thing you have to remember about kids is that we’re often explaining these sorts of things to people who haven’t even had biology in high school yet.”

Metzger noted that many adolescents are unable to grasp the lifelong consequences of infertility.

“It’s always a good theory that you talk about fertility preservation with a 14-year-old,” he said, “but I know I’m talking to a blank wall. They’d be like, ‘ew, kids, babies, gross.’ Or, the usual answer is, ‘I’m just going to adopt.’ And then you ask them, ‘Well, what does that involve? Like, how much does it cost?’ ‘Oh, I thought you just like went to the orphanage, and they gave you a baby.’ . . . I think now that I follow a lot of kids into their mid-twenties, I’m always like, ‘Oh, the dog isn’t doing it for you, right?’”

WPATH tells the public that surgical and hormonal treatments are tested and safe, but what members say amongst themselves is an entirely different matter.

In 2022, for instance, Marci Bowers, WPATH’s transgender president and a pelvic and gynecologic surgeon based in California, made the disputed claim that puberty blockers are “completely reversible.” In the internal forum however,  she acknowledged that such treatment is “in its infancy.”

Bowers also told her colleagues the “fertility question has no research.”

There is an emerging body of scientific evidence that point to the potential harms of hormonal treatments and puberty blockers, including lower bone density, and infertility in patients.

The leaked emails also show that WPATH doctors discussed the risk of developing cancer following hormone treatment.

In once case, a 16-year-old girl who had been on puberty blockers for several years and testosterone for one year developed two liver tumors that an oncologist concluded were caused by the hormones.

One doctor discussed a transgender colleague who died of cancer after being on testosterone for years.

“I have one transition friend/colleague who, after about eight to 10 years of [testosterone] developed hepatocarcinoma [a form of liver cancer],” the doctor wrote.

“To the best of my knowledge, it was linked to his hormone treatment … it was so advanced that he opted for palliative care and died a couple of months later.”

WPATH adopted its current Standards of Care in 2022 after scrapping a draft chapter about ethics and removing minimum-age requirements for children starting puberty blockers or undergoing sexual-modification surgeries.

It had initially recommended 16 to start hormones and 17 for surgery.

The WPATH files also demonstrate how the activist doctors cavalierly approach critical questions such as when to begin the radical treatments on minors.

In one conversation, a member asked for advice about a 14-year-old patient, a boy who identified as a girl and had begun transitioning at 4.

The child insisted on a vaginoplasty, a surgery that removes the penis, testicles and scrotum and repositions tissue to create a nonfunctioning pseudo-vagina. It requires a lifetime of dilation. Was he too young at 14?

Bowers didn’t recommend the surgery, explaining “the tissue is too immature, dilation routine too critical.”

In lay terms, that means boys who are too young do not have enough penal tissue for the surgery and the surgeon must harvest intestinal lining to build the faux vagina. Even Bowers admits that can lead to “problematic surgical outcomes.”

She would know since she has performed more than 2,000 vaginoplasties. Her highest-profile patient is 17-year-old Jazz Jennings, the transgender star of reality TV show “I Am Jazz.”

Three corrective surgeries were required to fix problems from the original vaginoplasty.

“She had a very difficult surgical course,” Bowers admitted in a 2022 appearance on the show. “We knew it would be tough — it turned out tougher than any of us imagined.”

Knowing this, Bowers still told colleagues in the internal discussion forum that the best age for an adolescent to undergo surgery was “sometime before the end of high school does make some sense in that they are under the watch of parents in the home they grew up in.”

Christine McGinn, another transgender plastic surgeon from Pennsylvania, agreed. McGinn has performed “about 20 vaginoplasties in patients under 18” and thinks the “ideal time in the U.S. is surgery the summer before the last year of high school. I have heard many other surgeons echo this.”

McGinn said waiting until teens are older than 18 and in college is problematic because “there are too many stressors in college that limit patients’ ability to dilate.”

The members also discussed common complications for phalloplasty in which a nonfunctioning pseudo-penis is fashioned from a female patient’s forearm or thigh tissue.

The surgery, which requires a full hysterectomy and surgical removal of the vagina, often has serious consequences, including “pelvic inflammatory disease, vaginal atrophy, abnormal pap tests and incontinence.”

Several colleagues described patients struggling with debilitating bowel problems, bleeding and excruciating pain during sex (“feeling like broken glass”).

They said vaginal estrogen creams and moisturizers as well as hyaluronic acid suppositories “can be helpful.”

The files also expose WPATH’s embrace of even more disturbing sex “nullification” surgeries for patients who do not feel either male or female and identify only as nonbinary.

Doctors have performed horrific “de-gendering” surgeries in an effort to create a sexless and smooth cosmetic appearance in these people “that is unknown in nature,” The Post reported. These surgeries result in bodies that “resemble department-store mannequins.”

There is even an experimental “bi-genital” surgery that attempts to construct a second set of genitals.

In 2017, when tabloids reported a 22-year-old man had spent $50,000 to surgically remove his sex organs so he could “transform into a genderless extra-terrestrial,” it seemed a one-off oddity.

But WPATH has enshrined that concept in its Standard of Care — the same document in which the group endorsed for the time first time chemical or surgical castration for patients who identify as eunuchs. (WPATH even linked to the Eunuch Archives, where men anonymously share castration fetishes.)

These science-fiction-like surgeries are not only reserved for adults.

“How do we come up with appropriate standards for non-binary patients?” asked Thomas Satterwhite, a San Francisco-based plastic surgeon who has operated on dozens of patients younger than 18 since 2014. “I’ve found more and more patients recently requesting ‘non-standard’ procedures.”

What are nonstandard procedures? They include “non-binary top surgery,” a mastectomy without nipples. There are brutal procedures for girls that eliminate all or part of the vagina and for boys that amputate the penis, scrotum and testicles.

One San Francisco surgical clinic proclaimed on its website that the goal here “is a smooth, neutral body that is cosmetically free of sexual identification.”

Meanwhile, WPATH members mostly dismiss the mounting number of disgruntled detransitioners who regret the choices they made as youths after they reach adulthood.

One case involved a 17-year-old boy, just graduated from high school, who had been on testosterone for two years. He was reported to be “very distraught and angry. He reports he feels he was brainwashed and is upset by the permanent changes to his body.”

A self-described “queer therapist” argued that young people cannot be brainwashed. “In my experience, those stories come from people who have an active agenda against the rights of trans people.”

Bowers said that “I do see talk of the phenomenon [detransitioners] as distracting from the many challenges we face.”

detrans subreddit currently has over 53,000 members.

Rachel Levine, the transgender assistant secretary for health, is a WPATH member who has nothing but praise for the organization.

According to Levine, WPATH “assesses the full state of the science and provides substantive, rigorously analyzed, peer-reviewed recommendations to the medical community on how best to care for patients who are transgender or gender non-binary. It is free of any agenda other than to ensure that medical decisions are informed by science.”

In contrast, Shellenberger said “transgender healthcare,” which he calls “the pseudoscientific surgical destruction of healthy genitals in vulnerable people,” is comparable to the mid-20th-century use of lobotomies, or “the pseudoscientific surgical destruction of healthy brains.”

“It is a medical travesty playing out in real time, and the casualties are our children,” investigative journalist Gerald Posner concluded at the Post.

Finally, here's Matt Walsh with his usual acerbic take on this totally disgusting shitshow...

“It’s Only Temporary and Won’t Require US Boots in Gaza”

 Biden will announce tonight in his State of the Union the next phase of US involvement in the Mideast. The US will build a temporary ship docking pier in Gaza that will not require boots on the ground.

US to Build an Offshore Pier in Gaza

The Wall Street Journal notes Biden Seeks to Boost Emergency Aid to Gaza With Offshore Pier

President Biden is set to announce in his State of the Union speech Thursday that the U.S. military will install a temporary pier off the Gaza coast for cargo ships to unload food, water and other emergency supplies, boosting the direct American role in addressing the strip’s humanitarian crisis.

Biden directed the military to carry out the emergency project, aiming to ease food shortages and lack of shelter and medical services for Gaza’s 2.2 million residents, according to U.S. officials who briefed reporters ahead of Biden’s speech Thursday evening.

Once the pier is in place, aid shipments enabled by the U.S. and a coalition of partners and allies will flow to Gaza, initially from Cyprus, according to U.S. officials who briefed reporters ahead of Biden’s speech Thursday evening.

The forces that will be required to complete this mission are either already in the region or will begin to move there soon, they said. The mission, which is expected to last only temporarily, won’t require U.S. boots on the ground in Gaza, officials said.

“It certainly will be complex to work out, but I think the more avenues we have to get assistance in the more we will be able to reliably move it around within Gaza as well,” a U.S. official said.

Six Key Questions and Answers

Q: Has anyone defined temporary?
A: No

Q: Has anyone stated the costs?
A: No

Q: Does the US have an endgame?
A: No

Q: Is the US ignoring new illegal Israeli settlements on the West Bank?
A: Yes

Q: Is the Biden administration concealing weapons shipments to Israel despite huge differences with Israeli Prime Minister Benjamin Netanyahu over Israel’s policy in Gaza and the west bank?
A: Yes

Q: Is Biden pressuring Congress for more “no strings attached” money for Israel despite huge differences with Netanyahu?
A: Yes

Biden is Hiding Weapons Shipments to Israel

Please note Biden is Hiding Weapons Shipments to Israel and Ignores Illegal West Bank Settlements

Weapons shipments that exceed a certain amount require notices to Congress. Biden’s solution is to make the shipments smaller and send hundreds more of them.

Please recall the “temporary” nature of US involvement in Iraq, Afghanistan, and Syria.

Bonus Questions

Perhaps this seems different given that it’s humanitarian.

But is there any reason to believe or trust anything that we are doing or saying about costs, the temporary nature, and no boots on the ground?

How temporary is temporary?

https://mishtalk.com/economics/its-only-temporary-and-wont-require-us-boots-in-gaza/

Silk Road Medical upped to Buy from Hold by Argus

 Target $24

https://finviz.com/quote.ashx?t=SILK&ty=c&ta=1&p=d

Viking started at Buy by Jefferies

 Target $110

https://finviz.com/quote.ashx?t=VKTX&ty=c&ta=1&p=d

Vaxxinity: Positive Data from Phase 1 Trial for Parkinson’s

 Vaxxinity, Inc. (NASDAQ: VAXX), a U.S. company pioneering the development of a new class of medicines, announced positive clinical data from its UB-312 program in Parkinson’s disease (PD) presented by Jean-Cosme Dodart, PhD, SVP of Research at Vaxxinity in an oral session at the AD/PD™ 2024 International Conference on Alzheimer’s and Parkinson’s Disease, held virtually and in Lisbon, Portugal from March 5 to March 9, 2024. UB-312 is the first active immunotherapy candidate to show reduction of pathological alpha-synuclein (aSyn) in cerebrospinal fluid (CSF) of PD patients.

UB-312 is designed to target aggregated forms of aSyn, the toxic species that underlies PD and other synucleinopathies. As part of the randomized, double-blind, placebo-controlled Phase 1 clinical trial, The Michael J. Fox Foundation (MJFF) funded a 2-year collaborative project between Vaxxinity, the Mayo Clinic, and UTHealth Houston to analyze CSF collected from patients, and to conduct exploratory research to assess target engagement.

The UB-312-induced antibodies showed preferential binding to aggregated aSyn and almost no binding to normal monomeric aSyn, as measured by dot blot. After a single priming regimen, those treated with UB-312 in the 300/100/100µg dosing group showed a 20% decrease from baseline in aggregated aSyn in the CSF compared to a 3% increase in the placebo group (p<0.05), as measured by a Seed Amplification Assay (SAA). Further, a post hoc analysis showed that patients with detectable UB-312-induced antibodies in the CSF exhibited improvement in activities of daily living as measured by the MDS-UPDRS II clinical scale (p<0.01). These data also suggest a correlation between reduction in aggregated aSyn in the brain and change in MDS-UPDRS II (R=0.52, p=0.001).

https://www.globenewswire.com/news-release/2024/03/07/2842413/0/en/Vaxxinity-Announces-Positive-Target-Engagement-Data-from-Phase-1-Clinical-Trial-for-Parkinson-s-Disease-at-AD-PD-2024.html

Biden sanctuary city pivot puts vulnerable Senate Democrats' stances in spotlight

 new White House stance on sanctuary cities has put vulnerable Democratic senators up for re-election in a difficult position as they traverse the issues of border security and illegal immigration. 

On Wednesday, Fox News Digital asked several Democratic senators in competitive states whether they agreed with the White House's shift toward encouraging local jurisdictions to cooperate with Immigration and Customs Enforcement (ICE). This marks a change from President Biden's previous statements. 

Sen. Tammy Baldwin, D-Wis., said in a statement to Fox News Digital: "Wisconsinites have said loud and clear they want real action that fixes our broken immigration system, secures our Southern border, and ensures that anyone who is a violent threat to our communities is prosecuted – and I am committed to working with anyone to do just that."

Sens. Jon Tester, Tammy Baldwin, Bob Casey and Sherrod Brown Getty Images© Photographer: Stefani Reynolds/Bloomberg via Getty Images | Bill Clark/CQ-Roll Call, Inc via Getty Images | Bill Clark/CQ-Roll Call, Inc via Getty Images | Bill Clark/CQ-Roll Call, Inc via Getty Images

While Baldwin stated her support for addressing both illegal immigration and the border, she did not answer whether she believes local municipalities should cooperate with ICE or turn over illegal immigrants who are detained. 

In a statement last month, Biden's White House said, "We welcome local law enforcement’s support and cooperation in apprehending and removing individuals who pose a risk to national security or public safety."

"When a local jurisdiction has information about an individual who could pose a threat to public safety, we want them to share that information with ICE," the statement continued. 

Sen. Tammy Baldwin attends a news conference after a meeting with Senate Democrats at the U.S. Capitol on Nov. 29, 2022. Drew Angerer/Getty Images© Drew Angerer

The White House's statement differed from Biden's previous stance on sanctuary city policies. During a Democratic presidential primary debate in 2020, he notably said "no" when he was asked whether arrested illegal immigrants should be turned over to ICE. After he entered office, Biden attempted to place a moratorium on deportations for 100 days, which was ultimately blocked by a federal judge. 

"I voted for our bipartisan, Border Patrol Union-supported bill that would staff up our law enforcement, stop fentanyl from coming into the U.S., and invest in border security," Baldwin said in her statement, referencing a bipartisan border security and immigration measure that was killed by Republicans following former President Donald Trump's coming out against it. "Republicans need to come back to the table on this compromise because the consequences of inaction are unacceptable." 

In the past, the Wisconsin Democrat has voted against cloture on motions that would allow the Senate to move forward with bills seeking to withhold federal grants for sanctuary cities. Such occasions occurred in 20182016 and 2015.

Sen. Jon Tester asks questions during a Senate Banking Committee hearing on Capitol Hill on Sept. 12, 2023. Drew Angerer/Getty Images© Drew Angerer

Montana Democratic Sen. Jon Tester's campaign declined to comment, referring Fox News Digital to his office. 

"Senator Tester strongly believes local jurisdictions should cooperate with ICE," his office said in a statement. "He does not support sanctuary cities and believes anyone who enters the country must be vetted and go through legal channels that keep our nation secure."

Tester's strong stance against sanctuary cities presents a contrast with his voting history, however. Similar to Baldwin, the Montana Democrat voted against invoking cloture to proceed with bills aimed at preventing sanctuary city policies and halting federal grants from going to them. 

Sen. Bob Casey, D-Pa., joined Tester's opposition to sanctuary policies via a statement from spokesperson Maddy McDaniel. "Senator Casey doesn’t support sanctuary cities and believes all jurisdictions must cooperate with ICE and law enforcement at all levels, and has opposed Republican efforts to defund the COPS program which helps law enforcement keep communities safe," she told Fox News Digital. 

But on the same cloture motions to move forward with bills to stop federal funding for self-proclaimed sanctuary cities, Casey voted against it. 

Sens. Martin Heinrich, D-N.M., Jacky Rosen, D-Nev., and Sherrod Brown, D-Ohio, are also up for re-election in states considered competitive, according to the Cook Political Report. Asked about their positions on sanctuary cities, they did not respond to inquiries from Fox News Digital. 

The National Republican Senatorial Committee slammed the group of Democrats in pivotal 2024 races, telling Fox News Digital in a statement, "Senate Democrats have spent decades voting to open America’s borders and give millions in taxpayer dollars to illegal immigrants, now cities across the country are paying the price for their radical agenda."

"None of their candidates will be able to hide their disastrous records from the public," added NRSC spokesman Philip Letsou. 

The Democratic Senatorial Campaign Committee was contacted by Fox News Digital for comment and did not hear back at press time. 

https://www.msn.com/en-us/news/politics/biden-sanctuary-city-pivot-puts-vulnerable-senate-democrats-stances-in-spotlight/ar-BB1jrUgC