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Thursday, March 14, 2024

AstraZeneca to buy Amolyt Pharma for $1.05 bln to boost rare-disease portfolio

 Drugmaker AstraZeneca said on Thursday it would acquire endocrine diseases-focused firm Amolyt Pharma for $1.05 billion in cash, in a bid to boost its rare diseases portfolio.

France's Amolyt, backed by investors including Danish drugmaker Novo Nordisk's parent firm Novo Holdings and EQT Life Sciences, is currently in the late-stage development of a therapy for hypoparathyroidism called eneboparatide.

The deal, which includes an $800 million upfront payment and an additional contingent payment of $250 million on achieving a specified regulatory milestone, is expected to close by the third quarter of 2024.

Revenue from AstraZeneca's rare diseases portfolio, boosted by the $39 billion acquisition of Alexion in 2021, has swelled in recent years, to nearly $7.8 billion in 2023.

Eneboparatide, which is expected to be launched next year, has blockbuster potential, Alexion CEO Marc Dunoyer told Reuters in an interview.

Over the near decade since AstraZeneca fended off a takeover by U.S. rival Pfizer, CEO Pascal Soriot has rebuilt the Anglo-Swedish drugmaker's pipeline, which includes 13 blockbuster medicines - those that generate more than $1 billion in annual sales.

Last month, Soriot said it was a "good time" for AstraZeneca do deals, after a string of acquisitions including a licensing deal late last year that gave it an entry into the booming anti-obesity drug market.

https://finance.yahoo.com/news/1-astrazeneca-buy-amolyt-pharma-074534810.html

AC Immune Results and Corporate Update

 

  • ACI-24.060 ABATE Phase 2 trial to report Abeta-PET imaging results in Q2 and H2
  • ACI-7104.056 VacSYn Phase 2 trial in Parkinson’s disease on track for interim data in H2
  • ACI-24.060 for Alzheimer’s disease (AD) received FDA Fast Track designation
  • ACI-35.030 ReTain Phase 2b program in preclinical (pre-symptomatic) AD patients, initiated by collaboration partner
  • Cash of CHF 103 million at year end, plus the CHF 15 million milestone payment received on February 1, 2024 and the next CHF 25 million ACI-35.030-related milestone, provides funding into 2026

Biotech trade group pledges support for BIOSECURE Act, to boot member WuXi AppTec

 As CDMO giants Wuxi AppTec and WuXi Biologics come under mounting scrutiny for their alleged ties to Chinese government officials, they are losing a key ally in Washington, D.C.

Wednesday, the Biotechnology Industry Organization (BIO) said it's taking "important steps" to support U.S. national security. Those steps include supporting the BIOSECURE Act, which looks to prevent "adversary biotech companies" from obtaining federal funding.

BIO also plans to take steps to remove WuXi AppTec from its membership roster, the trade group said.

"Our adversaries abroad have stated that they intend to become the biotechnology center of excellence in the world," BIO CEO John Crowley said in a statement. "America and our allies cannot let this happen. Securing and advancing our preeminence in biomanufacturing will be one key component of a multi-prong approach to secure and advance this strategic imperative in biotechnology.”

BIO's decision comes shortly after the chairman of the House Select Committee on the Chinese Communist Party, Mike Gallagher, R-Wisconsin, began raising questions about whether the group should be forced to register as a foreign agent.

Gallagher recently asked U.S. Attorney General Merrick Garland to start a review of BIO's lobbying against the BIOSECURE Act, according to the publication.

Back in January, a bipartisan group of lawmakers began advancing legislative efforts to crack down on certain Chinese biopharma companies because of alleged ties to government officials and the Chinese military. The U.S. Senate's homeland security committee last week voted to advance a version of the BIOSECURE Act.

As WuXi Biologics' stock price crashed in late January, the company defended itself and said the lawmakers had mischaracterized its CEO, Zhisheng Chen. More recently, WuXi AppTec said it strongly objects to "blanket allegations and preemptive actions against our company without due process."

WuXi Biologics and WuXi AppTec are separate but associated “sister companies,” according to The Wall Street Journal.

Besides the two CDMO giants, the BIOSECURE Act targets Chinese genomics companies BGI Group, MGI and Complete Genomics.

https://www.fiercepharma.com/pharma/biotech-trade-group-pledges-support-biosecure-act-plans-boot-member-wuxi-apptec

French Stars And Wealthy Terrorized In Wave Of Violent Home-jackings

 By John Cody of RemixNews

Celebrities are being targeted across France in an unprecedented wave of “home-jackings,” which are burglaries accompanied by violence and kidnapping. The cases often involve “youths” recruited by experienced ringleaders, such as Kamel Z., who keep their distance from their criminal underlings to insulate themselves from any prosecution.

The country has a history of these violent home invasions, but recent months have seen an explosion of such cases, including well-known French figures, such as Vitaa, Bruno Guillon, Jean-François Piège, Anne-Sophie Lapix, and Nikos Aliagas.

2023 marks a new milestone

In a special television report by BFMTV, the French news outlet reviewed the most recent cases. On July 21, 2023, a gang broke into the Paris home of PSG’s Italian goalkeeper Gianluigi Donnarumma and his partner, with the perpetrators tying up and stripping both victims. Then, on Sept. 27, the same type of home invasion, with the victims also being stripped, occurred against Bruno Guillon in the Paris region. Guillon, a host on French TV, was threatened with a handgun while his wife was tied up, gagged, and threatened with a hammer. Their 14-year-old son was also tied up inside his room and clamped in place.

On Dec. 18, the home of Alexandre Letelier, who serves as the backup goalkeeper for PSG, was invaded. Both he and his partner were threatened with death in front of their two children, aged two and six. Just two days later, on Dec. 20, the singer Vitaa was kidnapped, along with her husband and three children, after being targeted inside their home in Rueil-Malmaison.

Just a few weeks later, on Feb. 6, 2024, a team broke into Aya Nakumra’s home in Seine-Saint-Denis in Paris. They beat him to the point of hospitalization and robbed his residence.

Other celebrities, such as Nikos Alliagas, a Greek-French entertainer and journalist, as well as journalist Anne-Sophie Lapix, have also been targeted by burglary teams, but those attempts were foiled.

As BMFTV reports, many of these celebrities are targeted due to their presence on social media, where they show off their luxury watches, handbags, and other items.

“They are known for having money and property,” said Laurent Nuñez, the Paris police chief. “You just have to follow certain Facebook or Instagram profiles. We find a lot of information, both about the property held by future victims, and then obviously on their addresses and lifestyle.”

Once the information has been collected, the criminals can take action. In most cases, they “pose as a fake deliveryman, from La Poste or Amazon (…) with a parcel in hand,” explains Djassim Belkourchia, a delegate of the Alliance Police Nationale union.

“Committing a home-jacking in the presence of the occupants often allows them to ask for information on the whereabouts of the goods that are sought, jewelry, luxury watches or computer equipment,” estimates Laurent Nuñez.

France powerless to stop the crimes

Although these crimes have picked up steam in recent months, they have long plagued France. In July 2021, Guillaume Pley, a television presenter, learned that his wife and son, along with their nanny, had been victims of a violent house-jacking while he was flying to the Cannes Film Festival.

In that case, three men barged into the house when the mother, Agathe, had opened the door expecting the nanny.

They pointed a gun at her son’s head, and told Agathe, “If you make any noise, you know what will happen.”

“It’s difficult for a mother, it’s a scene that she won’t forget,” he said about the incident.

The burglars were looking for a luxury watch they had seen the French host wearing on social media, but he had the watch on him during his flight.

“She thought she was going to die because they were very hard on her when they couldn’t find the safe. It made them a little crazy,” he said.

The burglars fled with a counterfeit version of the watch worth a few hundred euros.

Most of the criminals are minors

Following the home invasion of Guillon, two minors and two others who were barely adults were arrested.

“What characterizes the profile of these young perpetrators is that they are essentially all minors. They are perfectly known to the police and justice for acts of violence (…) sometimes even violence with drug trafficking weapons, and they have already been condemned by the judicial authorities,” said Philippe Franchet, the commissioner of the Versailles banditry repression police unit.

However, despite participating in these high-profile crimes, many of these youths have little experience with home-jackings. In most cases, they are recruited by professionals, such as the 27-year-old Kamel Z., who is well known to police and has seven convictions.

He is accused of recruiting young men across Paris, and in many cases, he pays them just a few thousand euros. These underlings do not know each other and often know very little about their targets.

“They already have some experience in the world of banditry and police techniques. They think they will protect themselves from investigations and criminal liability by using young people who are a little less experienced,” explains Philippe Franchet.

Kamel Z. has been indicted for home-jacking at Bruno Guillon’s house, but investigators are also exploring his role in other violent house-jackings.

The BFMTV report notes that these home-jackings are not just targeting celebrities, but also families with no public-facing role. The Merlin family, for instance, was targeted in Calais in April 2023. The mother, Aurelie, was confronted while sleeping on the sofa by a man wearing a white mask and a black hood.

“He started hitting me in the face. I was so paralyzed that I didn’t even feel the blows. I was not in pain, but I could feel the blood starting to flow down my cheek. He hit me again, he asked me for money and he ran away,” says the mother.

She described it as a traumatic event that has left her checking her windows every night out of fear someone could slip into the house.

One psychologist described these home-jackings as one of the most traumatic crimes anyone can experience.

“It’s someone who enters into their private space… The victim is marked in her mind, she knows that this is where the trauma took place and for her, to go back to rebuild herself, she needs to turn the page and therefore change homes very often,” said Marjorie Sueur, a psychologist.

In many cases, the victims are advised to change their homes and start over someplace else.

https://www.zerohedge.com/geopolitical/she-thought-she-was-going-die-french-stars-and-wealthy-terrorized-wave-violent-home

Wednesday, March 13, 2024

Biden admin mulls holding migrants fleeing gang-ravaged Haiti in Guantanamo: report

 The Biden administration is weighing a plan to use Guantanamo Bay to process Haitian migrants in the case of a mass exodus from the gang-ravaged nation, according to a report. 

A wave of violence has engulfed the Caribbean island in recent weeks, leading to concerns over a potential influx of illegal immigration from Haiti as the US already grapples with record-levels of migrant encounters at the southern border under President Biden. 

The plan to potentially use Guantanamo Bay as a processing site calls for expanding an existing migrant center on the naval base, which is separate from the military prison where dozens of notorious terrorist suspects are being detained, a US official told CNN.

The Biden administration is considering using a migrant center at the US Naval base in Guantanamo Bay as a site to hold people fleeing Haiti’s recent wave of gang violence.AFP via Getty Images

The Migrant Operations Center in Guantanamo, which is about 200 miles west of Haiti, has been used to house migrants picked up by the US Coast Guard in the Caribbean for more than 30 years. 

Guantanamo Bay was previously prepped for a potential wave of Haitian migrants in 2010, after an earthquake ravaged the country, according to the outlet.

In 2022, the Biden administration also considered using the migrant center at Guantanamo Bay to temporarily hold Haitians fleeing a previous surge in gang-related violence on the island. 

The White House did not respond to The Post’s request for comment. 

Haiti’s prime minister announced plans to resign amid the uptick in violence.REUTERS
The Guantanamo Bay migrant center is separate from the military prison which houses suspected terrorists.AFP via Getty Images

Florida Gov. Ron DeSantis revealed plans Wednesday to dispatch over 250 soldiers and dozens of boats and aircraft to the Keys and the southern waters of the state in anticipation of a mass migration from Haiti. 

“We cannot have illegal aliens coming to Florida,” the governor said in a statement. 

Gangs are estimated to control 80% of Haiti’s capital city Port-au-Prince, according to estimates from the United Nations.

The nation has declared a state of emergency over the violence.

Haitian gang leader Jimmy “Barbecue” Chérizier has vowed to continue fighting until Prime Minister Ariel Henry resigns.

On Tuesday, in response to international pressure, Henry announced that he would resign after a traditional presidential council is convened.

https://nypost.com/2024/03/13/us-news/biden-administration-considers-holding-haitian-migrants-in-guantanamo-bay-report/

Mapping Credit Card Delinquency Rates In The US By State

 Credit card debt carries a hefty bill in America, and falling behind on payments can be extremely costly for cardholders.

This graphic, via Visual Capitalist's Marcus Lu, shows credit card delinquency rates across 50 U.S. states, as of Q3 2023. This data comes from a WalletHub study published in January 2024.

Which States Have the Lowest and Highest Delinquency Rates?

Credit card delinquency is when a cardholder falls behind on required monthly payments. Credit agencies are often notified after two months of delinquent payments.

WalletHub examined proprietary user data on the average number of delinquent credit card tradelines—also known as credit accounts—across states. Here they are from lowest to highest:

RankStateShare of Credit Card
Tradelines Delinquent (%)
1Iowa12.9
2Massachusetts13.9
3Hawaii13.9
4Rhode Island14.7
5Washington14.7
6Florida14.8
7New York14.9
8California15.1
9New Hampshire15.5
10Alaska15.6
11New Jersey15.6
12Colorado15.7
13Utah15.8
14Vermont16.1
15Montana16.1
16Illinois16.5
17Oregon16.6
18Idaho17.0
19Ohio17.5
20Connecticut17.8
21Maine18.0
22Nebraska18.1
23Wyoming18.1
24Maryland18.4
25Kansas18.4
26Wisconsin18.5
27Virginia18.7
28Nevada19.1
29South Dakota19.3
30Arizona19.8
31Minnesota19.8
32Pennsylvania20.2
33Michigan20.9
34North Dakota21.3
35Delaware21.4
36Missouri22.4
37New Mexico22.6
38Georgia23.1
39North Carolina24.0
40Indiana24.3
41Texas24.7
42West Virginia25.2
43Tennessee26.2
44South Carolina26.9
45Kentucky27.6
46Oklahoma28.2
47Arkansas30.1
48Alabama30.5
49Louisiana31.7
50Mississippi39.1

No state had credit delinquency rates of less than 10%, with Iowa coming the closest at 12.9%.

That puts Iowa ahead of wealthier states like Massachusetts (13.9%), Washington (14.7%), and New Hampshire (15.5%).

At the bottom end was Mississippi, which had 39% credit delinquency rates to end 2023. That’s well ahead of the next-lowest states Louisiana (31.7%) and Alabama (30.5%).

It’s notable that the American South had higher rates of delinquency almost across the board. The five states with the highest rates of credit card delinquency are all located in the southeastern region of the country, and Texas had a higher delinquency rate (25%) than other majorly populated states like Florida (14.8%) and New York (14.9%).

https://www.zerohedge.com/personal-finance/mapping-credit-card-delinquency-rates-us-state

Republican Warns Of Biden Order Allowing Illegal Immigrants, Felons To Vote

 by Jack Phillips via The Epoch Times (emphasis ours),

A Republican secretary of state sent a letter this week to the Department of Justice (DOJ) alerting it to an executive order signed in 2021 that he says will allow felons and illegal aliens to register to vote in elections.

In the letter to Attorney General Merrick Garland, Republican Mississippi Secretary of State Michael Watson wrote that a Biden-signed executive order has led to agencies under Mr. Garland’s charge “attempting to register people to vote, including potentially ineligible felons and to co-opt state and local officials into accomplishing this goal.”

The order, which the White House described as an effort to promote “access to voting,” suggested that it was designed to eliminate racial discrimination at the polls. It told federal agencies, including the DOJ, to “consider ways to expand citizens’ opportunities to register to vote and to obtain information about, and participate in, the electoral process.”

Mr. Watson took issue with one provision that directed the DOJ to ensure that the U.S. Marshals Service change jail and “intergovernmental agreements” to mandate that the facilities “provide educational materials related to voter registration and voting,” and “facilitate voting by mail, to the extent practicable and appropriate.”

The problem, according to Mr. Watson, is that those materials may be given to people who can’t vote such as felons and illegal aliens. State officials are also essentially being forced to comply with the rules, he said.

“Our understanding is that everyone in the Marshals’ custody is given a form advising them of their right to register and vote,” his letter said, according to Fox News. “Providing ineligible non-citizens with information on how to register to vote undoubtedly encourages them to illegally register to vote, exposing them to legal jeopardy beyond their immigration status.”

The letter said that the secretary of state’s office believes that providing a form to illegal immigrants who are jailed to advise them of their right to vote “undoubtedly encourages them to illegally” do so and exposes them to “legal jeopardy.”

It also noted that some individuals in jail custody “only have fleeting ties to Mississippi and do not meet the residency requirements necessary to be a Mississippi voter.”

“Many outside groups performing voter registration and vote harvesting services are partisan entities with a history of being unreliable. There have been documented instances of these groups providing incorrect directions to voters,” the Republican official warned. “It is not proper for the Federal government to push partisan groups into the voting process in Mississippi or any other state.”

The Epoch Times contacted the DOJ for comment but didn’t receive a reply by press time.

Speaking to Fox News, Mr. Watson said the issue should be immediately considered because the 2024 election is just months away. Citing the significant number of illegal border crossings in recent years, the secretary said they could try to register to vote and cast ballots in the coming months, while other Republican officials in recent years have warned that illegal immigrants could register to vote and cast ballots in favor of Democratic candidates.

If you look at what’s going on at the border when you’ve got so many illegal aliens pouring into our country, imagine the efforts used to get them to register to vote and that’s what this is all about,” he told the outlet on March 11. “It’s about control, it’s about continuing their power, and unfortunately that puts our country in a terrible position, so it’s immediate and it’s something where we hope they will respect our request to stop the program.”

A group of more than 1,000 illegal aliens walk toward a U.S. Border Patrol field processing center after crossing the Rio Grande from Mexico in Eagle Pass, Texas, on Dec. 18, 2023. (John Moore/Getty Images)

With just eight months to go before the November election, illegal immigration has increasingly become a focus among American voters, according to recent opinion polls. A poll released in late February showed that about six in 10 Americans believe illegal immigration is now a serious problem and a majority now back the construction of a border wall, which former President Donald Trump has championed.

During President Joe Biden’s State of the Union speech to Congress, he made reference to an illegal immigrant who allegedly murdered a college student, using the term “illegal” to describe the individual.

But he later retracted his comments over the weekend, telling MSNBC that he “shouldn’t have used the term illegal.” Instead, the president said he would use the term “undocumented” immigrant—a term that has risen to prominence among Democratic politicians and legacy news outlets in recent years.

When asked the same question last week, the president replied, “Technically, he’s not supposed to be” in the United States.

The president also said on March 9 that “they built the country,” referring to illegal immigrants. “The reason our economy is growing. We have to control the border and more orderly flow,” he said.

https://www.zerohedge.com/political/republican-warns-biden-order-allowing-illegal-immigrants-felons-vote