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Sunday, March 17, 2024

Cyberattack isn't threatening major for-profit systems' bottom lines, execs say

 The nation’s largest for-profit health systems reassured investors Tuesday that the Change Healthcare cyberattack, though disruptive in the short term, is a “transitory” event that’s unlikely to have a material impact on their businesses.

Systems like HCA Healthcare broadly acknowledged that their organizations are “better positioned than many others to weather” payment disruptions due to their scale, liquidity and their capacity to redirect claims to another vendor, per HCA Chief Financial Officer Bill Rutherford.

“We did use Change Healthcare and their products for a large portion of our billing interface system,” Rutherford said Tuesday at the Oppenheimer Annual Virtual Healthcare Conference. “We have worked diligently over the past two-and-a-half weeks to convert to another vendor [and] we’re now almost fully converted. … We were very fortunate that we already had an established relationship with another electronic billing vendor.”

Tenet Healthcare CEO Saum Sutaria, M.D., said during a session at the Barclays Global Healthcare Conference that Change is “an important vendor” but that the system only uses it in some of its hospitals. Its ambulatory care business, United Surgical Partners International, and its physician business both do not rely on Change, he said.

He stressed that the security breach did not extend from Change’s systems into Tenet’s—an important point for Tenet as its Conifer revenue cycle management business works with third-party clients that would have also been at risk.

Tenet, Sutaria explained, keeps Conifer’s billing edits and other proprietary processes “on the premises rather than in the cloud, and so they were unaffected. So we’ve been able to produce clean claims in our environment.

“The difficulty has been, frankly, submitting them electronically,” he said, though these have not led to any interruptions in business operations.

Universal Health Services CFO Steve Filton, who also spoke at Barclays, said his system doesn’t use Change for any outbound claims. Because “certain payers” do use them for inbound claims, however, “we think the effect may be 5% to 6% of our total claims,” he said.

Similar to HCA, UHS had another vendor that it had previously contracted with and so was able to switch over some physician groups that were using Change for their outbound claims, Filton said.

UHS does rely on “miscellaneous applications like automated cash posting” from Change, but recent commentary from the company suggests that many applications could come back online this week, he said.

“That’s disruptive, but over the short term I don’t think it’ll be a big deal,” he said. “It feels to me like this is mostly a transitory impact that will extend over three, four or five weeks, but after that shouldn’t be much of an issue.”

For Filton, the experience underscores the need for health systems to consider “a greater level of redundancy among all these applications,” he said. “… It just makes sense that in a lot of these applications, we don’t have a single user, single source vendor, just in case something like this arises.”

Tuesday’s comments strike a contrast with the criticism and alarm bells ringing among smaller healthcare providers and industry trade groups.

In a comment note issued Friday, Moody’s Investors Service warned that “providers with small scale, a weak financial profile, who only use Change and have little headroom in meeting debt covenants stand to suffer the most from the disruption.”

Monday, the Massachusetts Health & Hospital Association released a report that 12 hospitals and health systems in the state were suffering over $24 million in reimbursement losses daily. With nearly three-quarters of Massachusetts systems currently posting negative operating margins, “the cash flow problem … is especially worrisome,” it wrote.

The federal government has worked to lower the bar for providers in need of advance payments and other supports and has been pressuring Change Healthcare parent company UnitedHealth Group and other insurers to do more for cash-strapped providers.

UnitedHealth Group put together a temporary funding assistance program in early March, which was blasted by provider associations like the American Hospital Association as “not even a Band-Aid on the payment problems” their memberships face. Another statement released last week from the Federation of American Hospitals—which represents for-profit hospital systems like HCA, Tenet and UHS—pointed to the “gravity” and expanding fallout of the cyberattack. It called for Congress and the administration alike to put together a response “on a scale to mitigate this unprecedented attack.”

Though their organizations are somewhat shielded, the for-profit executives speaking in Tuesday’s events acknowledged that the incident is weighing down nearly the entire healthcare industry—including UnitedHealth Group itself.

“It’s obviously quite disturbing that we have a cyberattack on systems that, in many ways, form a critical engine of liquidity in the healthcare system,” Tenet’s Sutaria said. “Having been through this a couple of years ago, I can imagine what UnitedHealthcare is going through, the state of confusion that can exist in this type of environment. … It’s very disturbing that this kind of thing can happen.”

https://www.fiercehealthcare.com/providers/change-healthcare-cyberattack-isnt-threatening-major-profit-systems-bottom-lines-execs

Senate Finance Committee grills Becerra on HHS' delayed relief in Change cyberattack

Leading senators want the Department of Health and Human Services (HHS), insurers and hospitals alike to know they’re keeping a close eye on the fallout from Change Healthcare’s cyberattack.

During his opening comments for a hearing Thursday on the president’s proposed HHS budget for 2025, Senate Finance Committee ranking member Mike Crapo, R-Idaho, acknowledged the department’s recent guidance and flexibilities for those impacted by one of the most disruptive cybersecurity incidents in the industry’s history.

However, he also told HHS Secretary Xavier Becerra that “the over two-week delay resulted in [avoidable] uncertainty. Already financially vulnerable rural hospitals and providers, with little to no cash reserves, required immediate action by the Administration to ensure payrolls could be met and services could continue without interruption.”

Crapo capped his comment by urging HHS to provide prompt updates to industry and Congress “on efforts to limit further disruption.”

The committee’s chair, Ron Wyden, D-Oregon, went a step further and held the incident as evidence that policymakers must strengthen cybersecurity requirements for the private healthcare sector. Payers and providers alike have recently “become so large, it is creating a systemic cybersecurity risk” attracting attention from criminals and foreign actors, he said.  

The senator pointed to lines in HHS’ budget that would bring stronger penalties and mandatory cybersecurity standards for hospitals as “a great first step,” and urged the department to go a step further by introducing fines and accountability “for negligent CEOs, for example, which will enable HHS to better protect patients and our national security.”

When asked by Wyden to commit to such measures, Becerra responded that “we [HHS] look forward to working with you and every member on this dais on these issues.” 

The hospital industry has harshly denounced any mandatory cybersecurity requirements. In statements given shortly after HHS unveiled its cybersecurity strategy in December, American Hospital Association President and CEO Rick Pollack said that monetary fines, diminished reimbursement or other penalties would only serve to "diminish hospital resources needed to combat cyber crime and would be counterproductive to our shared goal of preventing cyberattacks."

Change Healthcare's incident was also the focus of comments from Sen. Maggie Hassan, D-New Hampshire, who highlighted four critical access hospitals in her state “which have not received what amounts to 98% of their expected payments for the last three weeks.” She said she had spoken with Becerra on the issue last week, and, since that time, one of those facilities has been approved for aid from Medicare.

“While this has been some progress, our providers are facing a really long road ahead,” she said to the secretary.

Hassan said she also spoke about the issue on Monday with President Joe Biden and Thursday morning with UnitedHealth Group CEO Andrew Witty. The latter, she said, was “what I would call a constructive conversation” that included “new commitments to provide cash aid today to the providers in my state who need it without any unfair or risky terms.”

Hassan closed her speaking time by asking Becerra how HHS will ensure the payer will stick to such commitments. The secretary pointed to a roundtable the White House held with payers and providers earlier this week and noted that a follow-up meeting is being held Friday.

"We're saying to [payers]: You need to start making payments,” Becerra said. “While you may not receive the actual bill, you have a general sense on a monthly basis what these providers bill you, so there's no reason to not work out advanced payments to these hospitals and other doctors and other providers."

Much of Thursday’s hearing focused on the administration’s proposed budget and health policy goals for the coming year.

Democrats broadly reinforced their support for White House priorities around reproductive health access and expanding Medicare drug price negotiations under the Inflation Reduction Act. Republicans steered the conversation toward HHS’ role in the border crisis and told Becerra to pass along their concerns that Medicare’s price controls are stifling pharmaceutical innovation.

The senators also sought confirmation from Becerra that pharmacy benefit managers' role in healthcare costs and telehealth coverage extensions are being pursued by the department.

https://www.fiercehealthcare.com/regulatory/senate-finance-committee-grills-becerra-hhs-role-change-healthcare-cyberattack

Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics

LUCIEN TURNER HTTPS://ORCID.ORG/0000-0001-6612-9745TRAN NGOC VAN LE HTTPS://ORCID.ORG/0000-0002-0342-2634ERIC CROSS HTTPS://ORCID.ORG/0000-0003-0482-5969CLEMENCE QUERIAULT HTTPS://ORCID.ORG/0009-0003-4835-8386MONTANA KNIGHT HTTPS://ORCID.ORG/0000-0002-5229-4122KRITTIN TRIHEMASAVA HTTPS://ORCID.ORG/0000-0002-4017-1256JAMES DAVISPATRICK SCHAEFERJANET NGUYEN HTTPS://ORCID.ORG/0009-0008-3291-0945, AND WILL BAILIS HTTPS://ORCID.ORG/0000-0001-9420-6250 Authors Info & Affiliations

DOI: 10.1126/sciimmunol.adj7238

Editor’s summary

Lymphocyte activation is accompanied by extensive transcriptional and metabolic changes that support cell division, in proportion to antigen affinity. Whether specific metabolites control affinity–driven lymphocyte expansion remains unclear. Using unbiased metabolomics, Turner et al. identified nicotinamide adenine dinucleotide (NAD) biosynthesis as a key component of T cell receptor (TCR) affinity–dependent metabolic reprogramming during early T cell activation. Downstream of TCR-dependent mitogenic signaling, pre-mitotic differences in single-cell NAD(H) levels predicted the rate at which T cells exited quiescence and their subsequent proliferative capacity. Together, these findings identify a key metabolic checkpoint during early lymphocyte activation that may contribute to inter- and intraclonal functional heterogeneity. (See related Focus by Panova and Richard)—Claire Olingy

Abstract

Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, we identify nicotinamide adenine dinucleotide (NAD) biosynthesis as a biochemical hub for the T cell receptor affinity–dependent metabolome. Through this central anabolic role, we found that NAD biosynthesis governs a quiescence exit checkpoint, thereby pacing proliferation. Normalizing cellular NAD(H) likewise normalizes proliferation across affinities, and enhancing NAD biosynthesis permits the expansion of lower affinity clones. Furthermore, single-cell differences in NAD(H) could predict division potential for both T and B cells, before the first division, unmixing proliferative heterogeneity. We believe that this supports a broader paradigm in which complex signaling networks converge on metabolic pathways to control single-cell behavior.

'‘Lab-leak’ proponents at Rutgers accused of defaming, intimidating COVID-19 origin researchers'

Fraudsters. Liars. Perjurers. Felons. Grifters. Stooges. Imbeciles. Murderers. When it comes to describing scientists whose peer-reviewed studies suggest the COVID-19 virus made a natural jump from animals to humans, molecular biologist Richard Ebright and microbiologist Bryce Nickels have used some very harsh language. On X (formerly Twitter), where the two scientists from Rutgers University are a constant presence, they have even compared fellow researchers to Nazi war criminals and the genocidal Cambodian dictator Pol Pot.

But now, their targets have had enough. A dozen scientists filed a formal complaint with Rutgers yesterday alleging that the two faculty members have violated the university’s policies on free expression by posting “provably false” comments that are often defamatory, and that some of their actions could even threaten scientists’ safety.

“It’s just a very clear daily harassment campaign directed at people that they disagree with. And I don’t think that’s right,” says letter organizer Kristian Andersen, an evolutionary biologist at Scripps Research who has co-authored papers in Science that link the origin of the pandemic to wildlife sold at a market in Wuhan, China. He and his colleagues also worry Ebright and Nickels are “engaging with the more extreme right,” including one person who has joked about executing some researchers.

In an emailed response to Science, Ebright called the researchers’ complaint “a crude effort to silence their opponents and, thereby, to prop up their collapsing narrative.” Nickels has posted a tweet thread of what he says are 11 “deliberates lies” in the letter. (In the past, the pair has also frequently criticized reporters and editors at Science in social media posts.)

The complaint to Rutgers is the latest volley in the heated debate about the origins of the COVID-19 pandemic—and in an equally fiery discussion about the limits of free speech in academia. Ebright and Nickels are proponents of the “lab-leak” theory, which says SARS-CoV-2 came from a virology laboratory in Wuhan and was perhaps even engineered to be more dangerous. Along with other scientists, journalists, and members of the public, they have raised concerns about a grant from the National Institute of Allergy and Infectious Diseases (NIAID) to the EcoHealth Alliance, a New York City nonprofit, that included funding for the Wuhan Institute of Virology to conduct studies of bat coronaviruses. That work could have created SARS-CoV-2, they argue. Ebright and Nickels are also among the founders of Biosafety Now, a nonprofit pushing for stronger oversight of labs that study dangerous pathogens.

The letter by Andersen and his colleagues, addressed to seven leaders at Rutgers and its Waksman Institute of Microbiology, where Ebright and Nichols work, cites several tweets by the duo and calls their behavior “unacceptable.” (Some of the tweets refer to scientists who did not sign the letter, including former NIAID Director Anthony Fauci and EcoHealth President Peter Daszak.) “To be clear, we welcome good faith criticism of our work,” the letter states. “However, we strongly believe that we, as scientists and academics, together with the institutions we serve, have a responsibility to engage in respectful, informed, and fact-driven debate.”

This month, Ebright and Nickels tweeted out an announcement for an EcoHealth fundraising event in April—although it did not include the time or the venue—and for a scientific conference in Washington, D.C., where Daszak is scheduled to speak. Encouraging their X followers to attend these events “put some of us and our colleagues in physical danger,” the letter states.

“I feel like things have reached a dangerous new low with these guys now egging on their followers, many of whom are unstable and easily influenced, to stalk scientists at meetings and private events,” says co-signer Michael Worobey, an evolutionary biologist at the University of Arizona. The letter points to a tweet from former EcoHealth employee Andrew Huff that included an animated image of a public hanging and suggested that’s how Daszak, Fauci, and University of North Carolina at Chapel Hill virologist Ralph Baric should be executed. Ebright and Nickels have regular exchanges with Huff on X.

The letter calls for “immediate and serious review” by Rutgers, which has guidelines stating that harassment and intimidation are not free expression, and that faculty are barred from harassing colleagues. “The letter has been received and appears to allege violations of Rutgers policy,” a Rutgers spokesperson says. “As is practice it will be forwarded to the appropriate offices for review.”

Andersen says he and his colleagues aren’t yet planning to file a defamation lawsuit against Ebright and Nickels, like the one that recently won climate scientist Michael Mann more than $1 million. “I don’t really want to see it go that way,” Andersen says. “I would much rather that we get back to proper scientific discourse where we can agree and disagree.”

But so far, the letter appears to have had no such impact. “The first, second, third, and fifth signers of the letter provably are fraudsters; the first and third signers provably are perjurers; and all signers provably are coauthors of fraudsters and perjurers,” Ebright tweeted today.

https://www.science.org/content/article/lab-leak-proponents-rutgers-accused-defaming-and-intimidating-covid-19-origin

Antibacterial activity of nonantibiotics is independent of standard antibiotics

MARIANA NOTO GUILLEN HTTPS://ORCID.ORG/0000-0001-7528-6777CARMEN LI HTTPS://ORCID.ORG/0000-0001-5597-0715BRITTANY ROSENER HTTPS://ORCID.ORG/0000-0002-1836-8503, AND AMIR MITCHELL HTTPS://ORCID.ORG/0000-0001-9376-3987 Authors Info & Affiliations

DOI: 10.1126/science.adk7368

Abstract

Numerous nonantibiotic drugs have potent antibacterial activity and can adversely impact the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic screens with thousands of barcoded Escherichia coli knockouts. We analyzed 2 million gene-drug interactions underlying drug-specific toxicity. Network-based analysis of drug-drug similarities revealed that antibiotics clustered into modules consistent with the mode of action of their established classes, while nonantibiotics remained unconnected. Half of the nonantibiotics clustered into separate modules, potentially revealing shared and unexploited targets for novel antimicrobials. Analysis of efflux systems revealed they widely impact antibiotics and nonantibiotics alike, suggesting that the impact of nonantibiotics on antibiotic cross-resistance should be investigated closely in vivo.

Fennec, Norgine to Commercialize PEDMARQSI in Europe, Australia, and New Zealand

 Agreement pairs Norgine’s commercial expertise and leading European footprint with PEDMARQSI®, the first and only approved therapy in the European Union and U.K. for reducing the risk of cisplatin-induced hearing loss in pediatric patients with localized, non-metastatic solid tumors

Fennec will receive €40 million in upfront and up to €210 million in additional commercial and regulatory milestones, and tiered royalties up to the mid-twenties

Enhances Norgine’s commitment to bringing transformative therapies to patients in Europe, U.K., Australia, and New Zealand who currently do not have access to a therapy to treat this life altering condition

https://www.globenewswire.com/news-release/2024/03/18/2847436/0/en/Fennec-Pharmaceuticals-and-Norgine-Enter-into-Exclusive-Licensing-Agreement-to-Commercialize-PEDMARQSI-in-Europe-Australia-and-New-Zealand.html

Planet Fitness Cancels Membership Of Woman Who Exposed Biological Male Using Women's Locker Room

 Planet Fitness is defending its decision to ban the membership of a customer in Alaska who spoke out about a “man in women’s locker room shaving.”

Patricia Silva left the gym in Fairbanks, Alaska and shared a video on Facebook where she said: “I just came out of Planet Fitness. There is a man shaving in the women’s bathroom.”

She also said the man "woman" was in the locker room at the same time as a 12 year old girl. 


She added: “I love him in Christ. He is a spiritual being having a human experience. He doesn’t like his gender so he wants to be a woman, but I’m not comfortable with him shaving in my bathroom.”

Planet Fitness didn't take kindly to the interaction and cancelled Silva's membership, telling ABC affiliate WDPE: “As the home of the Judgement Free Zone, Planet Fitness is committed to creating an inclusive environment.”

The gym said: “Our gender identity non-discrimination policy states that members and guests may use the gym facilities that best align with their sincere, self-reported gender identity. The member who posted on social media violated our mobile device policy that prohibits taking photos of individuals in the locker room, which resulted in their membership being terminated.”

Planet Fitness' website currently states: "At Planet Fitness, we celebrate and champion diversity and provide an environment where everyone feels accepted, respected and like they belong. Planet Fitness prohibits discrimination and harassment that is based on gender identity or gender expression in the workplace and in our clubs. The following is our corporate policy regarding the accommodation of our members and team members in terms of their gender identity."

"Planet Fitness prohibits discrimination and harassment that is based on gender identity or gender expression in the workplace and in our clubs."