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Thursday, May 23, 2024

Bahraini King says looking forward to improved relations with Iran

 Bahrain's King Hamad bin Isa Al Khalifa said on Thursday in a meeting with Russian President Vladimir Putin that there is no reason to postpone the resumption of diplomatic relations between the kingdom and Iran, state news agency reported.

King Hamad added that the kingdom is looking forward to improve its relations with Iran.

Tiny Bahrain, home to the U.S. Navy Fifth Fleet, has long blamed Tehran for stirring up its own majority Shi'ite Muslim population against Bahrain's Sunni monarchy.

The government came down hard on protests in 2011 when demonstrators, many from the Shi'ite majority, rose up to demand the downfall of Bahrain's monarchy in the Arab Spring. Bahrain partly blamed that unrest on Iran, an accusation Tehran denied.

Bahrain was the only Gulf state to have supported the U.S. and U.K. strikes against the Iran-aligned Houthis in Yemen earlier this year after that group launched its Red Sea attacks against shipping.

https://www.yahoo.com/news/bahraini-king-says-looking-forward-155317059.html

'As questions grow for Germany, investors warm to France'

 For 65 years German electrical components maker Hager has straddled the Rhine with sites on either side, but lately the family-owned group has plumped for the French side to host its expansion plans.

Cuts to French business tax rates, help from local officials ready to go out of their way to identify sites for business expansion and even new wiggle room in notoriously rigid labour rules are making France a proposition hard to turn down, group chairman Daniel Hager told Reuters.

Seven years of pro-business reforms under President Emmanuel Macron have helped rebalance economic relations between the euro zone's two biggest economies.

Gone are the days when foreign investors would baulk at France's high taxes and 35-hour work week, compared with Germany's 40 hours, and France is also seeing record levels of foreign direct investment.

"Since President Macron's been in place, the business climate is distinctly more positive and welcoming to companies," Hager said.

While still investing in Germany, the group - a typical example of the small to midsize "Mittelstand" of often family-owned firms that account for 55% of German jobs - is ploughing 120 million euros ($130 million) into France's border region of Alsace.

With questions growing over Germany's economic growth model, Macron can worry less than his predecessors over whether France is at risk of being outclassed when he heads to Berlin on Sunday for the first state visit by a French president since 2000.

Back then, France had just enshrined in law a 35-hour work week - a turnoff to many foreign investors - while Germany would later double down on labour market reforms that helped usher in a decade of strong export growth from 2006.

In more recent years, German growth has sputtered due to the country's over-dependence on exports to China and previously on cheap Russian gas while creaking infrastructure, high power prices and tight fiscal policy have also weighed.

By contrast, France's long-term commitment to nuclear energy - with plans in place to invest at least 52 billion euros in six new reactors - is an increasing attraction for foreign tech investors like Microsoft, which aims to build power-hungry data centres there.

RECIPE FOR SUCCESS

With Germany struggling to gain momentum and Britain held back by the long fallout from Brexit, France has been Europe's top destination for foreign direct investment since 2019, according to an annual survey consultants EY.

This year it has already won a record 15 billion euros in investment commitments at an annual "Choose France" event Macron hosts yearly at the Versailles Palace for global CEOs.

Biden overtime pay rule challenged by US business groups

 A coalition of U.S. business groups has filed a lawsuit seeking to block a Biden administration rule that would extend mandatory overtime pay to 4 million workers, saying it goes too far.

The groups filed a complaint in Sherman, Texas federal court late on Wednesday claiming the U.S. Department of Labor lacked the power to adopt the rule and that it would force businesses to cut jobs and limit workers' hours.

The rule would require employers to pay overtime premiums to workers who earn a salary of less than $1,128 per week, or about $58,600 per year, when they work more than 40 hours in a week.

The current threshold of about $35,500 per year was set by the Trump administration in a 2020 rule that advocacy groups and many Democrats have said does not cover enough workers.

The business groups in the lawsuit said the costs of complying with the new rule "will force many smaller employers and non-profits operating on fixed budgets to cut critical programming, staffing, and services to the public."

The Labor Department declined to comment. In adopting the rule, the agency said that lower-paid salaried workers often do the same jobs as their hourly counterparts, but work more hours for no additional pay.

The groups involved in the lawsuit include the National Federation of Independent Business, the International Franchise Association and the National Retail Federation.

The case was assigned to U.S. District Judge Sean Jordan, an appointee of Republican former President Donald Trump.

The only other judge in Sherman, U.S. District Judge Amos Mazzant, in 2017 blocked a rule that would have raised the overtime salary threshold to about $47,000.

Mazzant said the cutoff was so high that it would sweep in some management employees who are not entitled to overtime pay under federal wage law.

"The Department’s 2024 Overtime Rule largely repeats the errors of the 2016 Rule and fails to address the flaws previously identified by this Court," the business groups said in their lawsuit.

Under the new rule, the salary threshold will increase to $43,888 on July 1 and to $58,656 on Jan. 1, 2025. And starting in 2027, the threshold will automatically increase every three years to reflect changes in average earnings.

https://finance.yahoo.com/news/biden-overtime-pay-rule-challenged-134357618.html

'Personalized Noninvasive Brain Stimulation Shows Promise in Early Alzheimer's'

 Personalized repetitive transcranial magnetic stimulation (rTMS) targeting the hippocampal network improved cognitive and functional performance in patients with early Alzheimer's disease (AD), new research showed.

The improvements were evident 4 and 8 weeks after treatment and correlated with increased functional connectivity in the hippocampal-cortical network.

"The positive results of our study suggest that rTMS could be considered an add-on treatment for AD," lead investigator Young Hee Jung, MD, PhD, Department of Neurology, Myongji Hospital, Hanyang University, Goyang, Korea, and colleagues wrote. 

The study was published online on May 6 in JAMA Network Open

Promising Nondrug Add-on?

rTMS has emerged as a promising intervention for AD, but choice of stimulation site is key to the therapy's efficacy. 

For their study, Jung and colleagues employed personalized functional MRI (fMRI) connectivity analysis to guide hippocampal network-targeted stimulation coupled with a personalized 3D-printed frame to secure the coil to the optimal target site. 

They randomly allocated 41 adults with early AD and evidence of an amyloid biomarker to personalized rTMS or sham stimulation (20 sessions over 4 weeks), with assessments conducted at 4 and 8 weeks.

Thirty participants (mean age, 70 years; 60% women) completed the 8-week trial: 18 in the active rTMS group and 12 in the sham group.

Compared with the sham group, the rTMS group showed significant improvement in the AD Assessment Scale-Cognitive Subscale (ADAS-Cog), particularly in the memory domain, at 8 weeks (primary outcome: = .002). The between-group difference in improvement on the ADAS-Cog was also significant at 4 weeks (= .007).

The rTMS group also showed a larger improvement on the Clinical Dementia Rating-Sum of Boxes scale than did the sham group at 4 weeks (= .05) and 8 weeks (= .008) and the Seoul-Instrumental Activity Daily Living scale at 8 weeks (= .002); thus, there were two secondary outcomes. 

The fMRI connectivity analysis showed that rTMS increased functional connectivity between the hippocampus and precuneus, which correlated with improvements in the ADAS-Cog (=.005). 

"As a core region in the default mode network (DMN), the precuneus is critically involved in episodic memory retrieval. Its abnormal activity with reduced functional connectivity is considered a biomarker of early AD," the study team wrote. 

"Thus, our neuroimaging results aligning with the critical role of the precuneus are noteworthy because the measurable changes in the precuneus supported the improvement in clinical scores. These changes could serve as a biomarker for treatment effectiveness, further strengthening the credibility of our network-targeting rTMS approach to modulate the hippocampal-cortical memory network," they added. 

Taken together, the researchers say their results "support the consideration of rTMS as a potential nonpharmacological treatment for AD."

Funding for the study was provided in part by Remed Co Ltd. Three authors report they have a patent pending for the design and production of personalized masks. 

https://www.medscape.com/viewarticle/personalized-noninvasive-brain-stimulation-shows-promise-2024a10009t6

'Athletes With Heart Problems Can Continue to Play'

 Physicians should use shared clinical decision-making to help manage a return to play for athletes with arrhythmias, according to a new consensus statement from the Heart Rhythm Society.

The statement was released at the society's annual meeting in Boston and published simultaneously in the journal Heart Rhythm.

"Traditionally, the guideline going back 20 years reflected a paternalistic approach that if you have a certain condition, we shouldn't risk it, you shouldn't play," Eugene Chung, MD, MPH, MSc, director of the sports electrophysiology clinic at Massachusetts General Hospital, Boston, and vice-chair of the consensus statement writing committee, said in an interview. "But as time has passed, the experience that we gained, as research and data have been accumulated, we realize those approaches have been too restrictive.

"So, with increasing data behind it and experience taking care of these patients, more and more we can recommend a path to returning to sport and play for patients, even with conditions we would've normally restricted before, such as hypertrophic cardiomyopathy."

The statement builds on past recommendations from the American Heart Association and the American College of Cardiology and the European Society of Cardiology, along with other previously published recommendations.

The statement emphasizes that physicians should consider how various treatment options, such as medication, ablation, or device implantation, might affect a person's athletic performance when making decisions about how to manage their condition. The statement noted that data have not confirmed an increased risk of life-threatening arrhythmias from continued sports participation for patients who are closely managed. 

Notable Updates

Three specific updates in the consensus statement are most noteworthy, Chung said.

  • In patients with arrhythmia who are taking medication for the symptoms, physicians should perform a stress test to document that the arrhythmia has been suppressed before allowing them to return to play. Stress testing should closely resemble the activity they're doing, Chung added.
  • The recommendation for first-line atrial fibrillation ablation in athletes has been upgraded to Class 1 from Class 2A in previous guidelines. "We felt that there are enough data — albeit mostly in the general population — paired with observation data, that athletes do just as well as the general population, and that promoting exercise, especially moderate level exercise, helps reduce atrial fibrillation," he said.
  • Patients with the Wolff-Parkinson-White pattern on electrocardiography require a close workup and monitoring. "Data over the past 10 years have shown that risk is not as low as we once thought, and we emphasize that patients with this type of pattern on ECG should see an expert," Chung explained.

Shared decision-making is heavily emphasized in the guidelines. Chung gave as an example people who participate in sports that require strenuous arm motion, such as rowing or weight lifting, who need a defibrillator or pacemaker. There are now subcutaneous options more amenable to those activities, Chung pointed out. "But to go down these decision trees, we want to certainly involve the patient and their family where appropriate and make sure we're all on the same page," he said.

Return to Play

This document updates and builds on the evidence supporting return to play, said T. Jared Bunch, MD, a professor at University of Utah School of Medicine, Salt Lake City, who specializes in arrhythmias in athletes.

"It's the right time and the right place," he said. "It's really needed, and some of it is in the context of the history of how we've restricted return to play."

The shared decision-making component is important, Bunch said, because "it brings in the patient, their interests and desires."

"Everybody has inherent thresholds of risk they want to take," he said. "In a young child, they're thinking in the immediate now and may not have a long-term perspective, so parents are important."

The next step is to evaluate the recommendations laid out in the statement, Bunch added. "Now the society has the impetus and need to evaluate the impact of what we're doing," he said. "If we allow more kids to participate in return to play, we need to have the research infrastructure to make sure that it's safe, that event rates aren't changing, that it supports our recommendations because throughout the guideline some of the recommendations were not based on a lot of strong evidence. These are small populations, and these are rare events."

https://www.medscape.com/viewarticle/athletes-heart-problems-can-continue-play-2024a10009ny

White House Makes 9 Corrections To Transcript Of Biden's NAACP Speech

 by Eric Lundrum via American Greatness,

On Monday, the White House was forced to make nine different corrections on the transcript of Joe Biden’s speech to the NAACP...

As Fox News reports, Biden made multiple mistakes during his speech which reflected his increased age and cognitive decline.

Among other errors, Biden incorrectly stated that he was Vice President when the Chinese Coronavirus pandemic began, and further claimed that Obama gave him instructions on how to combat the pandemic; Donald Trump was President when the COVID pandemic began, and Mike Pence was Vice President at the time.

“When I was vice president, things were kind of bad during the pandemic,” said Biden.

“And, what happened was Barack [Obama] said to me: ‘Go to Detroit — help fix it.’”

The transcript was altered to say “recession” instead of “pandemic,” hinting that Biden was referring to the 2009 economic recession at the beginning of Obama’s first term.

Thus, the transcript now reads:

“And when I was vice president, things were kind of bad during the pandemic [recession], and what happened was Barack said to me, ‘Go to Detroit and help fix it.’ Well, poor mayor, he spent more time with me than he ever thought he was going to have to.”

Biden also claimed that the Affordable Care Act, colloquially known as “Obamacare,” saw American families save $800,000 a year.

He also said that he was fighting against corporate landlords who are “keeping rents down.”

He erroneously referred to the group hosting him as “the NAAC.”

Furthermore, Biden mispronounced words such as “inspiring” and “insurrectionists,” instead saying “inspiresing” and “erectionists.”

In a statement following the correction, Acting Deputy Press Secretary Sam Michel ignored the mistakes and simply said that “we’re focused on the substance of the transcript and the heart of President Biden’s speech.”

Biden’s numerous gaffes since taking office have drawn even greater scrutiny to the 81-year-old president, the oldest Commander-in-Chief in American history.

His mistakes have ranged from calling out to recently-deceased members of Congress during speeches, repeating instructions on teleprompters that were not meant to be spoken aloud, and outright false statements regarding his career and his personal history.

His apparent senility has become a top issue in the looming general election campaign against former President Donald Trump.

https://www.zerohedge.com/political/white-house-makes-nine-corrections-transcript-bidens-naacp-speech

Blood Test for Colon Cancer Screening May Miss Some Precancers, FDA Staff Says

 FDA reviewers questioned the potential benefits of Guardant Health's blood-based test for colorectal cancer (CRC) screening in documents released ahead of an advisory committee meeting on Thursday.

The Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committeeopens in a new tab or window will be asked to discuss several issues involving the Shield test, including whether its performance supports its use as a primary CRC screening option, especially given its low sensitivity for advanced adenomas.

The Shield test is an in vitro diagnostic blood test intended to detect CRC-derived alterations in cell-free DNA. Guardant is seeking approval for Shield as a screening test for individuals 45 years or older at average risk for the disease. The company suggests the test "should be considered alongside other CRC screening modalities, like colonoscopy, and is not a replacement for diagnostic colonoscopy or surveillance colonoscopy in high-risk individuals."

FDA staffers indicated that the benefit of the test is that it may increase compliance with CRC screening and detect earlier-stage cancer, "which may potentially cure the patient and also potentially prolong survival when treated," they wrote in an executive summaryopens in a new tab or window.

On the other hand, the test comes with the risk of failing to detect a patient with advanced adenoma, "which can later become neoplastic, losing the opportunity to prevent or prolong the onset of colorectal cancer," the staffers wrote.

Shield was evaluated in the pivotal ECLIPSE trialopens in a new tab or window -- a multisite, prospective, non-randomized, observational study designed to evaluate the clinical performance of the blood-based test in patients 45 to 84 years of age who were of average risk for CRC.

Results from the study showed that the cell-free DNA blood-based test had a sensitivity of 83.1% for CRC and a specificity of 89.6% for advanced neoplasia. However, among 1,116 participants with advanced precancerous lesions, the test was positive for only 147, for a sensitivity of 13.2%.

Thus, the FDA wants the panel to discuss the risks and benefits of a CRC screening test with such low sensitivity for the detection of advanced adenomas, and to discuss "potential mitigations which might be deployed to ensure physicians and patients are able to make informed choices regarding screening test options to mitigate clinical risks of the Shield test's advanced adenoma sensitivity."

In its own executive summaryopens in a new tab or window ahead of Thursday's panel, Guardant acknowledged Shield's limited advanced adenoma detection could result in harm "if the screening test is used only once in a lifetime."

"Given Shield's expected higher adherence and the extended dwell time of adenomas progressing to CRC, the risk of limited advanced adenoma detection and accrued harm would be reduced," the company said. It added that it expects Shield to improve overall CRC screening rates, "which outweighs the harm from individuals pursuing Shield over other CRC screening options."

The FDA also wants the advisors to discuss whether a post-approval study evaluating the benefits and risk of programmatic CRC screening over time with Shield would be beneficial.

While the FDA is not required to follow the advice of its advisory committees, it typically does.

https://www.medpagetoday.com/gastroenterology/coloncancer/110279