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Friday, May 24, 2024

'In Haiti, we must not repeat public health mistakes of the last decade'

 This Thursday, after a meeting between President Ruto of Kenya and President Biden, Kenya recommitted to deploy a United Nations-authorized police force to Haiti to help quell the gang violence that has brought the Caribbean nation to a standstill. But as contractors build a base to host these Kenyan forces, memories of a painful chapter resurface — the U.N.’s calamitous role in sparking a cholera outbreak in Haiti over a decade ago. 

The images are still searing: U.N. peacekeepers recklessly mismanaged sewage disposal at a base near Mirebalais, Haiti, in 2010, contaminating a major river and inadvertently introducing a cholera strain from Nepal. What followed was one of the world’s worst cholera epidemics in recent history, claiming over 10,000 Haitian lives.  

Over the last decade, as an infectious diseases doctor and public health practitioner, I have witnessed children, the elderly and pregnant women needlessly suffer and die from this ancient scourge, and fought alongside colleagues to implement centuries-old solutions for a disease from which no one should die in the 21st century.  

The unintended consequences of U.N. intervention in Haiti extend well beyond cholera. Allegations of peacekeeper abuses, from rape and theft to exploitation, further eroded public trust, underscoring how imposed foreign interventions can devastate communities. The U.N.’s lack of accountability and inadequate remediation efforts only compounded the trauma. 

The parallels today are concerning; Kenya itself is combatting a cholera outbreak reminiscent of the Nepalese cholera outbreak that seeded Haiti’s epidemic in 2010, and it is unclear what guardrails have been placed to prevent or address other public health mistakes. To avoid history repeating itself, public health accountability will be paramount. 

First, as Kenya prepares its mission to Haiti, robust preventive measures are critical: Kenyan soldiers must be rigorously tested, provided antibiotics, vaccinated before deployment and provided support to prevent the spread of new strains of cholera and other infectious diseases. Stringent sanitation, waste and environmental protocols with independent monitors are non-negotiable. Mechanisms to prevent and deal with possible human rights abuses akin to those documented during recent military interventions in Haiti should be transparently shared and rigorously enforced. 

But military intervention alone is insufficient. It must be paired with proactively addressing Haiti’s dire public health crises — the lack of clean water, sanitation infrastructure, food security and access to healthcare that enabled the resurgence of cholera and other infectious diseases and allows violence to persist.  

In 2016, the U.N. pledged $400 million to combat cholera. Yet to date this pledge remains largely unfulfilled. President Biden should support rapidly raising and deploying these funds to address ongoing public health crises. Ironically, the U.S. has already pledged $300 million in support of the military force. Lasting peace and stability will remain elusive without investments in basic human needs. 

Transparency and accountability are equally paramount after the U.N.’s prior failures. In 2011, victims of cholera demanded reparations from the United Nations, then filed suit in U.S. courts. These demands were either met with invocations of U.N. immunity or stalled in legal limbo. These events underscore how military interventions that operate with impunity can irreparably shatter public faith.  

As another police force prepares to enter Haiti, there is no better time than now to right these past wrongs. Victims of cholera should be given the reparations they deserve, and independent bodies should be established to monitor and respond immediately to any adverse events that may arise. 

To be sure, stringent standards and comprehensive approaches could delay a rapid response to a security crisis that has brought Haiti to a standstill, critics may argue. But the proposed solutions are well-supported; they have been stymied by international neglect, not infeasibility. More importantly, we should all grapple with the likelihood that a well-intentioned police intervention that does not respond to deep and long-standing grievances may result in worse outcomes than the status quo. 

As a base for yet another foreign intervention in Haiti rises, skepticism abounds whether this one can catalyze meaningful change. But if it has any prospect of succeeding where past efforts foundered, the proposed prevention protocols, holistic public health and human rights strategies, and reparation of past mistakes are truly the bare minimum. After compounding so many humanitarian disasters, the people of this long-beleaguered nation deserve novel solutions, justice and partnership grounded in human rights — not hollow gestures or repeated harms.  

The world is watching closely. 

Wilfredo R. Matias, MD, MPH, is an infectious diseases doctor at Harvard Medical School, a Paul and Daisy Soros Fellow and a Public Voices Fellow of the OpEd Project. His work focuses on responding to epidemic infectious diseases and advancing global health equity. 

https://thehill.com/opinion/4680481-in-helping-haiti-we-must-not-repeat-the-mistakes-of-the-last-decade/

Why younger adults are missing early signs of colon cancer

 Medical professionals are warning that more and more people under 40 are being diagnosed with colon cancer, saying they could be missing the early signs.

study, released Friday in the medical journal JAMA Network Open, said the most common warning sign for the cancer is passing blood in the stool. Abdominal pain and changes in bowel movements and anemia can also be “red flags.”

The paper analyzed 81 studies that examined nearly 25 million adults under 50 from various countries around the world.

Nearly half of the individuals in the sample presented with hematochezia, the passage of fresh blood in or with stool, and abdominal pain. One-quarter of individuals noted altered bowl habits.

The professionals also explained that delays in detection were common, and the average time from symptom presentation to cancer diagnosis was about 6 months. Due to a delay in diagnosis, younger adults often present with a more advanced disease by the time it is detected, they noted.

Colon and rectal cancer rates have risen among younger adults but have declined among older adults, who are more likely to get colonoscopies that can catch cancers, the report found.

Millennials born around 1990 are almost twice as likely at risk of colon cancer than people born in the 1950s, the New York Times reported.

Just as younger people may dismiss early warning signs, doctors could too. Anecdotal evidence suggests that physicians are less likely to suspect younger people have malignancies, the Times noted.

The analysis did not address the cause of rising rates among colon and rectal cancer in younger adults.

Their findings also come after an expert advisory panel said earlier this year that women should start regular screenings for breast cancer at age 40. The previous guidance said to start at 50.

https://thehill.com/policy/healthcare/4684914-colon-cancer-early-signs-young-adults-diagnosis-delayed/

Novo Nordisk once weekly insulin fails to get thumbs up from majority of FDA advisors

 FDA advisory panel expresses concerns about the risks of Novo Nordisk's once-weekly insulin icodec outweighing the benefits.

https://seekingalpha.com/news/4110352-novo-nordisk-once-weekly-insulin-fails-get-thumbs-up-majority-fda-advisors

Waste Disposal Firm Stericycle Is Exploring a Sale

 Stericycle Inc. is considering a potential sale after receiving takeover interest, people with knowledge of the matter said.

The Bannockburn, Illinois-based medical waste disposal company is working with a financial adviser as it weighs options, according to the people, who asked not to be identified discussing confidential information.

Stericycle’s stock rose as much as 21% on Friday for the biggest intraday gain in more than four years. The shares were up 14% at 3:30 p.m. in New York, giving the company a market value of about $4.7 billion.

The company could attract other medical waste management providers, as well as infrastructure funds, the people said.

Deliberations are ongoing and Stericycle could decide against pursuing a sale, the people said. A representative for Stericycle didn’t immediately provide comment.

Stericycle works to remove sensitive and hazardous waste material from hospitals, care centers and veterinary clinics across the US, according to its website. It also provides services to air and seaports, funeral homes and governments and the military, among others.

First quarter revenue at Stericycle fell 2.8% year-on-year to $664.9 million, figures for the period show. The company said the slip was primarily due to divestitures.

https://finance.yahoo.com/news/waste-disposal-firm-stericycle-exploring-191023256.html

Walmart announces $700m investment in Guatemala over five years

 Retail giant Walmart is pouring further resources into Central America, announcing a $700m investment plan for Guatemala over the next five years, Reuters reported.

The news comes just days after the company revealed a similar commitment of $600m to Costa Rica.

According to Reuters, Cristina Ronski, head of Walmart's Central American operations (Walmex), made the announcement during the ground-breaking ceremony for a new store in Guatemala.

This investment signals Walmart's continued focus on growth within the region.

The move also comes amidst positive sales figures for Walmex in Central America.

Guatemala, Nicaragua, and Honduras all reported double-digit same-store sales growth in 2024's first quarter, demonstrating strong customer demand.

While Costa Rica saw lower growth in the same period, the overall positive performance across the region suggests a promising market for Walmart's expansion plans.

The specific details of how the $700m will be allocated have not been disclosed yet.

However, considering the ground-breaking ceremony's timing, it is likely that a portion will be directed towards new store construction and renovations.

Investments in supply chain infrastructure and logistics improvements are also potential areas of focus, given their role in supporting sales growth.

This significant investment by Walmart highlights the company's confidence in the Central American market.

It is a strategic move that aims to capitalise on the region's economic potential and growing consumer base.

With a focus on bolstering its presence and operations in Guatemala, Walmart is well-positioned to further solidify its position as a leading retailer in the region.

https://finance.yahoo.com/news/walmart-announces-700m-investment-guatemala-124952870.html


House Panel Approves Measure To Rehire Troops Fired For Refusing COVID-19 Vaccine

 by Caden Pearson via The Epoch Times (emphasis ours),

The House Armed Services Committee adopted an amendment in the annual defense policy bill on May 22 that, if cleared through Congress, would force the Pentagon to rehire U.S. troops who were fired for refusing a COVID-19 vaccine.

The measure was adopted late on May 22 by lawmakers on the panel, who marked up and advanced their version of the annual appropriations bill, authorizing a defense budget of $849.8 billion.

The 2025 bill, titled the Servicemember Quality of Life Improvement and National Defense Authorization Act, will serve as the base text for forthcoming debate as it makes its way through Congress.

On May 22, Rep. Nancy Mace (R-S.C.), who offered the amendment on rehiring veterans separated under the vaccine mandate policy, confirmed its adoption.

During the debate, she said the measure would direct the Pentagon to develop a strategy to recruit from among the thousands of servicemembers who “were made veterans overnight” under the COVID-19 vaccine mandate.

“This amendment seeks to address the loss of skilled, experienced personnel who were willing and able to serve their country and overcome the resistance of the Department in recruiting from this population,” Ms. Mace said ahead of a panel vote.

The Department has so far failed to recruit a significant number of servicemembers separated under the COVID mandate. This is unacceptable.

‘Vaccines Save Lives’

Offering a counter perspective after Ms. Mace spoke, Rep. Salud Carbajal (D-Calif.) said servicemembers are required to get a broad range of vaccines, including region-specific vaccines, when deployed to certain areas.

“Vaccines save lives,” Mr. Carbajal told lawmakers on the panel.

“I must say, it’s bewildering how the COVID-19 vaccine has become the boogeyman issue, but in reality, it is a readiness issue. We currently vaccinate our forces to protect them and to protect their fellow troops.”

Congress ended the Pentagon’s COVID-19 vaccine mandate in 2022 and last year directed Defense Secretary Lloyd Austin to create a path back to service for those who were separated for refusing the vaccine.

On April 30, Mr. Austin told the panel that he didn’t know of any efforts to recruit servicemembers who had been previously let go under the mandates. Ms. Mace said on May 22 that this was “disappointing.”

The measure faces an uncertain future later this year when the committee meets with the Democrat-led Senate Armed Services Committee to reconcile differences in the National Defense Authorization Act before full passage in Congress.

According to the Pentagon, during fiscal year 2023, the military services collectively missed recruiting goals by about 41,000 recruits. This was attributed to a “smaller eligible population.”

Other reasons stated included the attractiveness of jobs in the private sector, younger generations having “low trust” in the military and following other career paths, and younger people having fewer families who served, decreasing their wish to follow suit.

Committee Advances Draft Defense Spending Bill

House Armed Services Committee Chair Rep. Mike Rogers (R-Ala.) said the 2025 defense spending bill considers the quality of life for servicemembers, boosting compensation money, improving housing, expanding health care and child care access, and other issues that directly affect troops and their families.

This is in addition to strengthening the military to face challenges posed by China, Iran, Russia, and North Korea, according to Mr. Rogers.

“Strengthening our military and investing in our defense is how we send our adversaries a message that we will not be intimidated,” he added.

The lawmakers authorized a defense budget of $849.8 billion in line with the debt ceiling agreement made earlier this year.

“For the first time in decades, the bill before us today carries a different short title. It is the Servicemember Quality of Life Improvement and National Defense Authorization Act. We did that to underscore the tremendous gains this bill makes toward improving the quality of life for all of our service members and their families,” Mr. Rogers said in a statement.

“No service members should have to live in squalid conditions. No military family should have to rely on food stamps to feed their children. And no one serving this country should have to wait weeks to see a doctor or mental health specialist. This bill goes a long way toward fixing those problems.”

He welcomed the bill’s passage through the committee.

The bill was introduced on April 18 by Mr. Rogers and ranking Democratic member Adam Smith (D-Wash.) to serve as the base text for the 2025 defense spending bill.

https://www.zerohedge.com/political/house-panel-approves-measure-rehire-troops-fired-refusing-covid-19-vaccine

Cogent Positive Updated Lead-In Data from Ongoing Phase 3 GI Cancer Trial

 

  • Bezuclastinib + sunitinib combination therapy reached median progression free survival (mPFS) of 19.4-months and 33% ORR in subset of advanced GIST patients with one prior treatment
  • Encouraging long-term safety and tolerability with combination bezuclastinib and sunitinib therapy in Part 1
  • PEAK Phase 3 guidance accelerated with enrollment completion now expected in 3Q 2024
  • Company announces new advanced GIST clinical trial sponsored by the Sarcoma Alliance for Research through Collaboration (SARC) and in collaboration with The Life Raft Group and Dana-Farber Cancer Institute