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Thursday, July 11, 2024

'America's venture capital system is breaking down - taking tech startups with it'

 Length and severity of the downturn in funding depend on how long the AI bubble lasts

After obtaining his economics PhD from Yale University in 1979, David Swensen was hired by Wall Street investment bank Salomon Brothers and, three years later, moved to Lehman Brothers. Three years after that, at the age of 31, he took an 80% pay cut and returned to Yale to manage the university's endowment.

Swensen later explained that he had accepted the job and pay cut because, "There are a lot of important things in life you don't measure in dollars and cents." For Swensen, some of these things were teaching college students, playing poker with Nobel laureate James Tobin, being on a summer softball team with Yale's then-president, Rick Levin, watching Yale hockey games, and coaching his children's baseball and soccer teams.

When Swensen took over Yale's endowment portfolio, it had a 62% allocation to U.S. stocks, 6% to developed stocks, and the rest mostly fixed income. When Swensen died in 2021, U.S. stocks were just 2% of the Yale portfolio, replaced by venture capital, leveraged buyouts, hedge funds and the like. Swensen's track record was impressive and many other endowments now emulate the "Yale Model."

Yet over past decade, the Yale Model has lagged behind the S&P 500 SPX. One explanation is that there are not enough low-hanging fruit. For example, when the demand for venture capital investments is modest, investors can be picky, but when the demand for venture capital investments far exceeds the supply of good ideas, many investors will be stuck with schemes that should never have been funded.

The consequences of dubious schemes were particularly evident in fiscal 2023, when Yale, Harvard University and many other prominent endowments lost money on their venture capital and private equity investments and their portfolios were trounced by the S&P 500 SPX.

This widely reported dismal performance is, in many ways, a chorus of canaries in a coal mine. Venture capital (VC) investments have always been lottery tickets. On average they disappoint but occasionally they pay off big.

For example, some startups funded between the 1960s and 2000s are now among America's most valuable companies, including Intel (INTC), AMD (AMD), Qualcomm (QCOM), Amazon.com (AMZN) and Alphabet (GOOGL). But recently, disappointments have been far more common than successes. Jay Ritter, a professor at the University of Florida, reports that the percentage of startups profitable at the time of their IPO had fallen to less than 20% in the late 2010s from about 80% in 1980 .

For years, the two of us have been warning of the dangers to America's startup system posed by big startup losses. In 2013, angel investor Aileen Lee coined the term "unicorn" for startups that were valued at $1 billion or more before they went public. We have been documenting the unprofitability of these unicorns along with their huge cumulative losses (see here, here, and here). Furthermore, almost 60% of America's publicly traded unicorns have cumulative losses larger than their revenues - a figure that doesn't include the dozens of publicly traded unicorns which have gone bankrupt or been acquired in the past two years.

Privately traded startups are almost surely doing even worse, because the best will IPO first. Thus, Morgan Stanley's European head of research reported in late 2023 that even the top 25% of privately held startups have an average EBITDA of minus 30%.

The Wall Street Journal, Financial Times and others are now confirming these risks. Scott Stanford, a cofounder and partner at ACME Capital, recently said that, "It's not crazy to think half the VC firms that were actively investing in the last decade will be sidelined and eventually collapse." Sara Ledterman, managing partner of 3+ Ventures, is even more pessimistic. She "estimates 3,200 funds have gone dormant over the past 14 months" while another "analysis found 8,538 VCs stopped investing in the past two years, leading to what some VCs have warned will be a "zombie reckoning in 2024."

Startup shutdowns rose at an accelerated pace in 2023. Pitchbook reports that around 3,200 startups failed in 2023 and more than 2,000 VC firms effectively halted making new investments in startups in the first nine months of 2023. Similarly, Carta reports that among users of its database, startup shutdowns rose to a record high of 264 in the first quarter of 2024 from 72 in the first quarter of 2022 .

For publicly traded unicorns, eight went bankrupt or were acquired for below valuation prices in 2023 (Quotient technology, Coupa, Pear Therapeutics, Qualtrics, Blue Apron, Signify Health, Smile Direct Club, and Lordstown Motors). Several unicorns have followed suit so far this year: 23andme; Invitae; Nanostring Technologies and Fisker). Meanwhile, almost 400 tech companies have laid off workers this year so far, according to layoffs.fyi data - including two publicly traded unicorns (Gingko bioworks and Cue health).

A growing number of limited partners have begun reneging on their commitments.

Endowments, pension funds, trusts and their peers are the limited partners (LPs) that are at the heart of the venture capital system, since they channel funds to venture capital firms. Business Insider recently reported that a growing number of limited partners have begun reneging on their commitments. LPs are legally liable for money they have promised the VCs, but few VCs want the bad press and possible domino effects from suing LPs. Better to pretend that all is for the best in this best of all possible worlds. Keep collecting fees and keep hoping that greater fools will soon appear.

The length and severity of this startup meltdown depends on how long the current AI bubble lasts. Unless companies can figure out a way to make a profit on their AI spending spree, and do so quickly, many startup investors' dreams will dissolve into skepticism, disillusionment and panic. The canaries are warning us.

https://www.morningstar.com/news/marketwatch/20240711327/americas-venture-capital-system-is-breaking-down-taking-tech-startups-with-it

Ipsen Inks Potential $1B First-in-Class ADC Deal With Foreseen

 Ipsen is licensing another antibody-drug conjugate for its cancer pipeline. Under an exclusive agreement worth more than $1 billion, Foreseen Biotechnology announced Thursday it is granting global rights to Ipsen to develop, manufacture and commercialize a potentially first-in-class preclinical asset. 

Foreseen’s FS001 is an antibody-drug conjugate (ADC) that targets a novel, unspecified antigen overexpressed in “many solid tumors,” according to the company. The antigen, identified through proprietary proteomic and AI-powered platforms, plays a critical role in tumor growth and metastasis.  

Preclinical work on FS001 showed efficacy in multi-drug resistant cancer models, Foreseen contends. Under the licensing agreement, Ipsen now assumes responsibility for Phase I preparation activities including IND application submission, as well as all clinical development, manufacturing and commercialization activities. 

“As we prepare for the initiation of a Phase I clinical trial, we will evaluate FS001 in selected solid tumor types, which we hope will deliver critical new treatments for people living with cancer around the world,” Mary Jan Hinrichs, Ipsen’s senior vice president of early development, said in a statement. 

The deal comes at a time when ADCs continue to be a hot area of biopharma investment, with the global market exceeding $10 billion last year for the first time. Analysts project a $30 billion market by 2028 and companies are laying out the biobucks to get into the space. 

The Foreseen deal is Ipsen’s second foray into the ADC area this year. Ipsen inked a potential $900 million deal with Sutro Biopharma in April 2024. The company now has exclusive rights to Sutro’s STRO-003, which is in the final stages of preclinical development. Ipsen is responsible for Phase I prep activities with the ADC candidate.

STRO-003 targets the ROR1 tumor antigen which is known to be overexpressed in many different cancer types, including solid tumors and hematological malignancies, according to Sutro. 

https://www.biospace.com/article/ipsen-inks-potential-1b-first-in-class-adc-deal-with-foreseen-/

Astrana upped to Buy from Hold by Truist

 Target to $50 from $44

https://finviz.com/quote.ashx?t=ASTH&p=d

Emergent Ups Financial Position as Part of Multi-Year Transformation Plan

 Emergent BioSolutions Inc. (NYSE: EBS) today highlights several recent advancements in improving its financial health, marked by robust cash generation and meaningful debt repayment. As set forth in its operational plan to transform the company over the next several years, Emergent is diligently executing its strategy to enhance operational efficiency, streamline costs, and generate cash to increase profitability and reduce the company’s overall debt. This disciplined approach has enhanced Emergent’s financial position, as well as enabling a customer focused, leaner and more flexible organization, and enriching its opportunities to pursue strategic initiatives.

Emergent’s recent actions include:

  • Secured $250 million in U.S. government contract award modifications for four medical countermeasures
  • Announced a $30 million definitive agreement to sell its Baltimore-Camden manufacturing site, which is expected to close in the third quarter of 2024, subject to the satisfaction or waiver of customary closing conditions
  • Received $7 million for sale of its unimproved, empty building in Canton, Massachusetts
  • As disclosed yesterday in its SEC filing, the resolution of its contract dispute with Janssen Pharmaceuticals, Inc., including the impending receipt of $50 million in the third quarter of this year
  • Expected receipt of a development milestone payment as part of its Travel Health Business sale by year end

"Emergent is making steady progress toward cash generation and debt repayment, which is in service to our strategic plan to stabilize our financial position and ultimately transform the organization as we continue to be a global leader in public health preparedness," said Joe Papa, president and CEO of Emergent. "We remain committed to reaching our target of more than $100 million in debt reduction this year, while continuing to deliver vital medicines to our customers and patients, creating long-term and sustainable value for shareholders and working toward strengthening our balance sheet, so that we have a healthier financial foundation to support our company’s future direction."

Emergent will provide more on its 2024 financial outlook, incorporating any potential expectations related to these recent events, and other relevant information when it reports its second quarter financial results in August.

https://www.globenewswire.com/news-release/2024/07/09/2910253/33240/en/Emergent-BioSolutions-Continues-to-Drive-Improved-Financial-Position-as-Part-of-Multi-Year-Transformation-Plan.html

OKYO Pharma to Initiate Neuropathic Corneal Pain Trial for OK-101

 

  • Phase 2 randomized, placebo-controlled trial in neuropathic corneal pain (NCP) patients planned to begin in Q3, 2024
  • OK-101 is believed to be the first IND clearance granted by FDA for a drug to begin clinical studies specifically to treat patients suffering with neuropathic corneal pain (NCP), a major unmet medical need
  • OK-101 demonstrated statistically significant pain relief as measured by visual analogue scale (VAS) from Day 29 through the last study visit at Day 85 in a Phase 2 trial of dry eye disease, as well as reduced neuropathic corneal pain (NCP) in a preclinical mouse model
  • NCP is an Orphan disease as listed in the National Organization for Rare Disorders

Housing crisis in Spain's cities drives rise in homelessness

  Francisco Carrillo sobbed with relief as he lay on the bed in his new apartment in Madrid provided by a charity after three years of sleeping rough in the backroom of a theatre.

The 62-year-old pensioner found he couldn't afford rental prices in the capital when he moved from Jaen in southern Spain to seek treatment for throat cancer.

"Tonight, I'm going to sleep like a baby," he said.

Carrillo is one of a growing number of Spaniards who have found themselves priced out of the market amid a shortage of social housing and regulations that deter long-term rentals.

The situation has been exacerbated by a boom in holiday lets on platforms such as Airbnb and Booking.com, which has spurred a wave of protests across the country in recent weeks.

The rate of homelessness has risen by 24% since 2012 to 28,000 people, according to official statistics while, according to a Bank of Spain report, about 45% of people living in rented accommodation are at risk of poverty or social exclusion, the highest proportion in Europe.

Homelessness has increased substantially across Europe over the last decade, the European Commission said, but the extent of the problem in Spain is masked by young Spaniards opting to live with their parents for longer.

More than 60% of 18-34-year-olds live in the family home and Spain had the fastest rising rate of young people living with their parents among major European economies between 2008 and 2022.

Spain's social housing stock is just 1.5% of all homes compared to a European average of 9%, the report added.

Competition for apartments to rent privately is fierce. About 40 people answer each listing that comes on the market in Madrid, according to property listings website Idealista.

The Socialist government's current plan for public housing will add 184,000 units over the next three years. Prime Minister Pedro Sanchez said in May he would like the social housing stock to match the European average during his term ending in 2027.

But the Bank of Spain estimates that an additional 1.5 million more homes are needed to meet that target.

The 90,000 units-per-year pace of homebuilding is trailing growth in demand and far below the 650,000 homes built in 2008, according to official data.

Housing Minister Isabel Rodriguez said on Tuesday that the government had begun to work on a new plan to meet that target.

FILLING THE VOID

To fill part of the void left by the state, charities are turning to private capital - even if it's a fraction of what's required.

The flat provided to Carrillo by Mundo Justo (Fair World) belongs to Techo, a social investment fund that provides rental homes to charity groups working with the homeless, and which in April floated on the Spanish stock market with the support of 33 business partners, including global firms EY and CBRE.

Techo owns around 230 flats and works with 50 NGOs who charge rent at 30% below market rates. For investors it's an opportunity to secure a return while also boosting their environment, social and governance (ESG) scores, said Blanca Hernandez, chair of the real estate investment trust.

Another charity, Hogar Si, rents 400 apartments to the homeless. Two years ago it began to seek investors to buy some of those flats as a way to reduce costs.

José Manuel Caballol, head of the Hogar Si foundation, said the housing crisis requires a mix of private and public initiatives on social rent.

"We need to be much more ambitious," he said.

Big cities such as Madrid are also having to cope with migration from the countryside to urban centres where the jobs are, said Diego Lozano, CEO of the city's housing agency.

As many as 48,000 people are on a waiting list for social housing in Madrid. Lozano said the city is working to almost triple its social housing stock to 15,000 by 2030, but admitted that still won't meet demand.

He also blamed a recent law designed to protect tenants' rights by allowing vulnerable people to remain in a property for up to two years without paying rent, which he said had a cooling effect on owners weighing long-term rentals.

Landlords are demanding rent payment guarantees from tenants that the poorest can't provide, according to three NGOs consulted by Reuters.

Others are switching to the lucrative short-term market that isn't governed by the same regulations. The supply of long-term rentals has fallen 15% in a year, while short-term rentals mainly for tourists increased by 56% in the year to March, according to Idealista.

Pensioner Carmen Cajamarca, 67, received a letter giving her one month to leave her rented flat in the Madrid neighbourhood of Lavapies after the building where she has lived for 25 years was sold to an Argentine fund that is refurbishing its apartments for holiday lets.

Cajamarca said she will leave Madrid, and is delaying as long as possible as she searches for a new home.

"This is only for tourists ... and the people who have always lived here, where are we going to live?" she said.

The crisis is so acute that Spanish cities are trying to limit or phase out holiday apartments.

In Cadiz, Eva Orihuela joined a local movement to ban holiday lets after her 88-year-old mother Maria faced imminent eviction before the local soccer club stepped in to buy her home to let to her at the same rent.

Orihuela was relieved that her mother would continue to have a roof over her head.

"But there are many more Marias," she warned.

https://finance.yahoo.com/news/housing-crisis-spains-cities-drives-060947128.html

Canada takes step to acquire up to 12 submarines to guard Arctic

 Canada, looking to shore up its defense of the Arctic, is moving ahead to acquire up to 12 submarines and has started a formal process to meet with manufacturers, the defense ministry said on Wednesday.

Canada updated its defense policy this year with a focus on protecting the Arctic and dealing with challenges from Russia and China. The procurement of submarines is a critical step in implementing that strategy, the defense ministry said in a statement.

Citing global warming, Canada says the Arctic Ocean could become the most efficient shipping route between Europe and East Asia By 2050, thus raising the need to bolster maritime security.

"As the country with the longest coastline in the world, Canada needs a new fleet of submarines," Defence Minister Bill Blair said in the statement.

After meeting manufacturers, the ministry in autumn will post a formal request for information on the procurement, construction, delivery and operational capabilities of potential bidders.

Canada currently has a fleet of four submarines that the ministry said was growing more obsolete and expensive to maintain. The new fleet of submarines will be conventionally powered and capable of operating under ice.

Ottawa has been under U.S. pressure to boost defense spending to meet the 2% of gross domestic product agreed to by NATO allies in 2023. The defense policy update in April outlined billions more for the armed forces, including money for submarines, to take spending to 1.76% of GDP by 2030, up from the current 1.4%.

Canadian broadcaster CTV News, citing unidentified government sources, reported on Wednesday that Canada would unveil a plan on Thursday on how to reach its NATO commitment to spend two 2% of its GDP on defense.

The defense ministry did not immediately respond to a request for comment on the report.

https://ca.news.yahoo.com/canada-takes-step-acquire-12-214217556.html