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Wednesday, February 12, 2025

Bayer Backs New Effort to Shield Weedkiller From Claims It Failed to Warn of Cancer

 A renewed and expanded effort from chemical giant Bayer to shield itself from lawsuits that claim its popular weedkiller Roundup causes cancer brought dozens of protesters to the Iowa Capitol building Monday begging lawmakers to reject it.

The legislation, pending in Iowa and at least seven other states, would protect pesticide companies from claims they failed to warn that their product causes cancer if the product label otherwise complies with the U.S. Environmental Protection Agency's (EPA) regulations.

Similar efforts failed during 2024 legislative sessions in Iowa, Missouri, and Idaho. But this year, Bayer and a coalition of agricultural groupsopens in a new tab or window are doubling down. A broader media campaign is highlighting the importance of glyphosate-based Roundup for American agriculture. And they are getting help from a group that ran a Super Bowl ad in Missouri asserting the legislation is necessary to combat Chinese influence over the U.S. food supply.

Opponents, including those who rallied Monday in Des Moines, say the bills would limit the rights of people to hold companies accountable if their products cause harm. Speakers took turns telling stories of family members throughout the state who have been diagnosed with cancers and shouted out to lawmakers that Iowa's people are more important than corporate profits.

"I feel like we need accountability here in Iowa," said Nick Schutt, a part-time farmer whose mother, father, aunt, and two siblings have all had cancer diagnoses. "At the end of the day, multinational chemical companies like Bayer should be held accountable."

Bayer disputes the claims that Roundup causes cancer, but the company has been hit with about 177,000 lawsuits involving the weedkiller and has set aside $16 billion to settle cases. It contends those legal costs are "not sustainable" and is looking for relief from lawmakers concerned about the possibility that Roundup could be pulled from the U.S. market.

For crops including corn, soybeans, and cotton, Roundup is designed to work with genetically modified seeds that resist the weedkiller's deadly effect. It allows farmers to produce more crops while conserving the soil by tilling it less.

"It is the most important product in global agriculture," Liza Lockwood, Bayer's medical affairs lead in its crop science division, said during a recent Missouri Senate committee hearing.

Some farmers have echoed that assertion. If lawsuits force Roundup off the U.S. market, they contend that Chinese-made products may be the only alternative.

"Losing access to this one safe and effective tool will set off a domino effect that will threaten family farmers and our state's economy," Kevin Ross, a farmer from southwest Iowa, said to Iowa lawmakers. Ross detailed how, for 50 years, the American-made product has increased soil quality, decreased water runoff, and helped struggling farmers turn a profit.

An Expanded Field for Legislation

Last year, Bayer focused its lobbying efforts on Missouri, Iowa, and Idaho -- home, respectively, to its North America crop science division, a Roundup manufacturing facility, and the phosphate minesopens in a new tab or window from which its key ingredient is derived. Though bills passed at least one chamber in Iowa and Missouri, they ultimately failed in all three states.

This year, legislation providing legal protection against failure-to-warn claims already has passed the North Dakota House without any opposition. Similar bills have cleared initial committees in Iowa, Mississippi, and Missouri and are pending in legislative committees in Florida, Oklahoma, and Tennessee. A bill failed to get out of a Wyoming committee by a deadline.

Bayer officials said Monday that legislative efforts also are in the works in Georgia, Idaho, and the U.S. Congress. A promotional campaign from the Modern Ag Alliance, a coalition that Bayer supports, has targeted an even wider array of states.

New to the cause this year is the Protecting America Initiative, an organization concerned about China's influence on the U.S. economy and tied to Richard Grenellopens in a new tab or window, President Donald Trump's envoy for special missions and former acting director of national intelligence. The group ran a television ad Sunday in central Missouri during the Super Bowl urging support for the legislation. It said it has invested six figures to run the 30-second spot more broadly across Missouri and Iowa.

It also parked a truck containing a portable billboard outside the Iowa Capitol on Monday, encouraging support of the bill to stop Chinese-made chemicals from "infiltrating American farms."

Concerns About Cancer and Pesticides

Ads supporting legislation that could limit Bayer's legal liability have emphasized the importance of its weed-control products to agriculture.

"Farming's hard," one Facebook advertisement says. "But it's a little easier with glyphosate."

That ad offended Kim Hagemann, a suburban Des Moines resident who showed up to a crowded subcommittee meeting to share her opposition with lawmakers.

"Bayer is right, farming's hard, but dealing with cancer is even harder," said Hagemann, a member of one of the groups that organized Monday's protest.

Though some studies associate Roundup's key ingredient glyphosate with cancer, the EPA has said it is not likely to be carcinogenic to humans when used as directed. Yet the numerous lawsuits against Bayer allege glyphosate does cause non-Hodgkin lymphoma.

One of the many attorneys involved in the lawsuits against Bayer is Robert F. Kennedy Jr., Trump's nominee to serve as HHS secretary. Though the health agency oversees the FDA, it does not control the EPA and its labeling requirements.

The legislation supported by Bayer would provide a defense against failure-to-warn claims not only for Roundup but for other pesticide products that follow EPA labeling guidelines.

Richard Deming, MD, a cancer physician in Des Moines, said it often takes decades to determine a cause-and-effect connection between cancer and long-term exposure to low levels of chemicals. He said public policy should focus on mitigating that risk, not providing "immunity from responsibility."

"I don't think that ag chemicals cause as much cancer as cigarette smoking," Deming told the AP after speaking to lawmakers. But studies suggest "there's clear association between ag chemical exposure in the state of Iowa and cancer incidence."

https://www.medpagetoday.com/publichealthpolicy/publichealth/114185

Probiotics Linked to Decreased Mortality in Preterm Infants

 

  • Use of probiotics in neonatal units was associated with decreased mortality in preterm and low-birth-weight infants.
  • Rates of necrotizing enterocolitis and late-onset sepsis were not different versus those who did not receive probiotics.
  • Incidence of probiotic sepsis was rare.

Use of probiotics in neonatal units was associated with decreased mortality in preterm and low-birth-weight infants, a Canadian retrospective cohort study suggested.

Among 32,667 infants born before 34 weeks' gestation, probiotics were associated with decreased mortality rates (adjusted odds ratio 0.62, 98.3% CI 0.53-0.73), but not decreased rates of necrotizing enterocolitis (aOR 0.92, 98.3% CI 0.78-1.09) or late-onset sepsis (aOR 0.90, 98.3% CI 0.80-1.01), reported Belal Alshaikh, MD, MSCE, of the University of Calgary in Alberta, Canada, and colleagues.

For the 7,401 infants with a birth weight less than 1,000 g, probiotics were also associated with decreased mortality rates (aOR 0.58, 98.3% CI 0.47-0.71), but again not decreased rates of necrotizing enterocolitis (aOR 0.90, 98.3% CI 0.71-1.13) or late-onset sepsis (aOR 1.01, 98.3% CI 0.86-1.18), they wrote in Pediatricsopens in a new tab or window.

Incidence of probiotic sepsis was rare, occurring in 27 infants born before 34 weeks' gestation and 20 infants with a birth weight less than 1,000 g. Three infants with probiotic sepsis died, with the condition deemed a possible cause in two cases.

Despite results from previous meta-analyses showing reductions in necrotizing enterocolitis, mortality, and late-onset sepsis with probiotics in very preterm infants, "the adoption of probiotics among neonatal intensive care units (NICUs) varies because of a lack of pharmaceutical-grade products, low to moderate certainty on efficacy, and potential for harm in the form of probiotic sepsis," Alshaikh and colleagues noted.

Real-world dataopens in a new tab or window also reported cases of probiotic sepsis and mortality in preterm neonates, which led the FDAopens in a new tab or window and Health Canadaopens in a new tab or window to issue warning letters about probiotic use in NICUs.

"Given the importance of making informed decisions about probiotics, reporting of beneficial and harmful associations is essential," the authors wrote.

In a commentary accompanying the studyopens in a new tab or window, Roger Soll, MD, and Erika Edwards, PhD, MPH, both of the University of Vermont in Burlington, noted that "the reported effectiveness of probiotic supplementation in infants less than 1,000 g birth weight and the rare cases of probiotic sepsis give some comfort to those choosing to use available probiotic agents."

"However, the exact species of probiotic and the role of breastfeeding (and possible improvements in how we obtain and feed breast milk to critically ill preterm infants) require further research," they added. "The evidence that we have made little if any improvement in the rates of [necrotizing enterocolitis] over the past decade adds urgency to the efforts to find an effective product that will meet regulatory standards."

For this study, Alshaikh and colleagues included infants born before 34 weeks' gestation and admitted to 33 Canadian Neonatal Network units from January 2016 through December 2022. Infants who were moribund on admission, died within 2 days, were admitted more than 2 days after birth, had major congenital anomalies, or never received enteral feeds were excluded.

Of the 32,667 included infants, 57.5% received probiotics (median gestational age 29 weeks), and 42.5% did not (median gestational age 31 weeks).

Because of the retrospective observational nature of the study, there was risk for potential biases and confounding. In addition, because the study spanned more than 7 years, other strategies may have been introduced within NICUs and influenced mortality or necrotizing enterocolitis rates, Alshaikh and colleagues noted.

Furthermore, probiotic sepsis was defined based on the genera of Bifidobacterium and Lactobacillus, and the database used for the study did not collect information needed to determine the link between strains isolated and probiotics used. Finally, the research team did not have data on race and ethnicity.

Disclosures

The study was funded by the Canadian Institutes of Health Research.

The study authors reported no relevant conflicts of interest.

Soll reported serving as vice president of Vermont Oxford Network, being an unpaid member of the Vermont Oxford Network board of directors, and serving as director of the Vermont Oxford Network for Evidence-Based Practice. Edwards reported receiving grant funding from Vermont Oxford Network.

Primary Source

Pediatrics

Source Reference: opens in a new tab or windowAlshaikh BN, et al "Effectiveness and risks of probiotics in preterm infants" Pediatrics 2025; DOI: 10.1542/peds.2024-069102.

Secondary Source

Pediatrics

Source Reference: opens in a new tab or windowSoll RF, Edwards EM "Safety and efficacy of probiotics for preterm infants" Pediatrics 2025; DOI: 10.1542/peds.2024-069450.


https://www.medpagetoday.com/pediatrics/generalpediatrics/114183

Ozempic helps to reduce alcohol consumption and smoking, new study



Scientists at the University of Southern California monitored 48 people with alcohol use disorder, which can leave people with the inability to control their drinking despite negative consequences.

The drugs, best known for their use in weight loss and diabetes treatment, also appeared to reduce how many cigarettes people smoked.

The study, completed by scientists at the University of Southern California, confirms anecdotal reports that Ozempic and Wegovy users were getting fewer cravings for alcohol.

Scientists at the University of Southern California monitored 48 people with alcohol use disorder, which can leave people with the inability to control their drinking despite negative consequences.


All of the women had had more than seven drinks in a week in the last month, as well as two or more heavy drinking episodes.
The men had all had more than 14 drinks in a week in the last month, as well as two or more heavy drinking episodes.

After the nine-week trial, the researchers found participants who had received low doses of semaglutide, instead of the placebo, had reduced their drinking.

The injections reduced weekly alcohol cravings, reduced average drinks on drinking days, and led to fewer heavy drinking days


In fact, the injections were more effective than existing medications used to treat drinking problems.

The participants who smoked also saw significant reductions in how many cigarettes they smoked in a day.

More than 8,200 people died because of alcohol in 2023, according to data from Public Health England, a 42% rise on 2019. Alcohol is also a known cause of more than 60 illnesses.

Two drugs currently approved to reduce alcohol consumption aren't widely used.

"The popularity of Ozempic and other [similar drugs] increases the chances of broad adoption of these treatments for alcohol use disorder," said Professor Christian Hendershot, who led the study.

https://news.sky.com/story/ozempic-helps-to-reduce-alcohol-consumption-and-even-smoking-new-study-finds-13307800

Microsoft Drops USAID-Funded NewsGuard After Ted Cruz Starts Digging

 Microsoft has dropped NewsGuard, a left-wing fact checking organization they partnered with that has helped the advertising industry justify blacklists for independent conservative media sites such as ZeroHedge. 

The move came after Sen. Ted Cruz (R-TX) began investigating Microsoft for funding the online "media literacy" censorship tool created by NewsGuard to help guide "learners of all ages through the overwhelming landscape of online news and information."

Now we come to find out that NewsGuard was funded by USAID...

In response to Cruz, Microsoft claims their support of NewsGuard was limited to a one-time donation in 2018, and said it had asked NewsGuard to remove a claim on its website that read "NewsGuard's Media Literacy Programs are made possible thanks to generous support from Microsoft," Newsmax reports, citing a Senate Commerce Committee spokesperson.

NewsGuard has since removed any mention of Microsoft from their website.

"Big Tech is finally beginning to recognize the censorship of conservative viewpoints will no longer be tolerated by the American people," Cruz, chairman of the Senate Commerce Committee, said in a statement to Newsmax on Thursday.

"I am happy to see that the leadership at Microsoft has renounced their support of NewsGuard's so-called media literacy tool in response to my letter.

"NewsGuard's biased rating system stifles intellectual diversity, hinders critical thinking among young students, and undermines our nation's core values of free expression."

In his letter to Microsoft CEO Satya Nadella, Cruz pointed out that NewsGuard has targeted outlets such as The Federalist, The Daily Wire, and NewsMax, branding them as "unreliable," while left-wing outlets such as Jacobin, The Atlantic, and The New Republic are deemed reliable.

NewsGuard has also "found a willing partner in the American Federation of Teachers (AFT)" to use their "media literacy" tool browser extension used by over 800 public libraries worldwide.

In November, Federal Communications Commission Commissioner Brendan Carr, now chairman, wrote to the CEOs of Apple, Meta, Microsoft, and Alphabet demanding that they fess up about their censorship activities targeting conservatives.

Carr specifically identified NewsGuard, which exists to "censor free speech and conservative news outlets." -Newsmax

Major advertising agencies have used NewsGuard to censor conservative media - including Omnicom, Interpublic, Publicis, Magnite, PubMatic, TripleLift, Comscore, Zefr, and Giphy.

*  *  *

https://www.zerohedge.com/markets/microsoft-drops-usaid-funded-newsguard-after-ted-cruz-starts-digging

Hegseth Drops Bombshell Of Realism On Europe, Rules Out NATO Membership For Ukraine

 Trump's Defense Secretary Pete Hegseth has definitively poured cold water on Ukraine's hopes of gaining Washington backing to join NATO, at a moment he's visiting the alliance's headquarters.

Hegseth issued firm words on this crucial question directly to the faces of top Ukrainian officials in opening remarks before the Ukraine Defense Contact Group - the alliance of 50+ countries and the European Union who support Ukraine's military - which is meeting in Brussels this week.

The US defense chief not only ruled out NATO membership, but laid out that it is "unrealistic" to expect Ukraine’s borders to revert to pre-2014, in reference to Russian rule over Crimea.

"We want, like you, a sovereign and prosperous Ukraine. But we must start by recognizing that returning to Ukraine’s pre-2014 borders is an unrealistic objective." Hegseth said.

And that's when he finally spoke some realism on the tragic conflict which is about to reach the 3-year mark, something which has been sorely missing from Washington commentary:

"Chasing this illusionary goal will only prolong the war and cause more suffering," he stressed.

On the question of Zelensky's stated goal of gaining NATO admission, which many independent analysts have long warned would surely trigger Article 5 and hurl Russia and the West toward direct nuclear-armed confrontation, Hegseth said the following:

"The United States does not believe that NATO membership for Ukraine is a realistic outcome of a negotiated settlement."

He also vowed that no American troops would be sent to Ukraine as part of any future security agreement.

"Instead, any security guarantee must be backed by capable European and non-European troops. If these troops are deployed as peacekeepers to Ukraine at any point, they should be deployed as part of a non-NATO mission and not covered under Article 5. There also must be robust international oversight of the line of contact," the new Pentagon chief said.

He stressed that any potential security guarantees that result from negotiated settlement "should not be provided through NATO membership."

"To be clear," he continued, "as part of any security guarantee, there will not be US troops deployed to Ukraine."

And as expected, he reiterated President Trump longtime calls for allies to increase their defense spending to 5% of their GDP, as opposed to the current goal of 2% (which many are still not achieving).

"Members of this contact group must meet the moment … 2% is not enough," Hegseth said. "President Trump has called for 5%, and I agree. Increasing your commitment to your own security is a down payment for the future, a down payment, as you said, Mr. Secretary, of peace through strength."

He also revealed part of Trump's strategy for leverage against Moscow to get them to the peace table. "Lower energy prices coupled with more effective enforcement of energy sanctions will help bring Russia to the table," he claimed, despite Moscow having shown its ability to weather the sanctions storm and even prosper.

Source: US Mission to NATO

Later this week Treasury Secretary Scott Bessent will travel to Ukraine to meet Zelensky to talk about ways to end the conflict, but also as part of Trump efforts to secure access to the war-ravaged country's rare earth minerals. Given Hegseth's words, which could mark the final death knell for Ukraine's already long diminished hopes of achieving success, it looks like Washington under Trump is now quite serious about seeking a swift ending to the war and all its death and destruction.

https://www.zerohedge.com/geopolitical/hegseth-drops-bombshell-realism-europe-rules-out-nato-membership-ukraine

Putin Invites Trump To Visit Moscow In 'Highly Productive' Call, Ready For Peace

 US President Trump and Russian President Putin held a nearly hour-and-a-half call this morning which the US president described as "lengthy and highly productive."

Trump said on Truth Social that both leaders had extended invitations of "visiting each other's nations," while, the US leader said he would be calling Ukrainian President Volodymyr Zelensky "right now" to inform him about the call.

President Trump took to his Truth Social account to explain what was discussed (emphasis ours):

I just had a lengthy and highly productive phone call with President Vladimir Putin of Russia. 

We discussed Ukraine, the Middle East, Energy, Artificial Intelligence, the power of the Dollar, and various other subjects. We both reflected on the Great History of our Nations, and the fact that we fought so successfully together in World War II, remembering, that Russia lost tens of millions of people, and we, likewise, lost so many!

We each talked about the strengths of our respective Nations, and the great benefit that we will someday have in working together. 

But first, as we both agreed, we want to stop the millions of deaths taking place in the War with Russia/Ukraine. 

President Putin even used my very strong Campaign motto of, “COMMON SENSE.” 

We both believe very strongly in it. We agreed to work together, very closely, including visiting each other’s Nations. We have also agreed to have our respective teams start negotiations immediately, and we will begin by calling President Zelenskyy, of Ukraine, to inform him of the conversation, something which I will be doing right now

I have asked Secretary of State Marco Rubio, Director of the CIA John Ratcliffe, National Security Advisor Michael Waltz, and Ambassador and Special Envoy Steve Witkoff, to lead the negotiations which, I feel strongly, will be successful. 

Millions of people have died in a War that would not have happened if I were President, but it did happen, so it must end. 

No more lives should be lost! 

I want to thank President Putin for his time and effort with respect to this call, and for the release, yesterday, of Marc Fogel, a wonderful man that I personally greeted last night at the White House.

I believe this effort will lead to a successful conclusion, hopefully soon!

Most significantly, Putin spokesman Dmitry Peskov has announced immediately on the heels of Trump's statement that President Putin has invited Trump for an official state visit to Moscow

Below are breaking newswire headlines from the Russian side:

PUTIN INVITES TRUMP TO VISIT MOSCOW DURING PHONE CALL, EXPRESSES READINESS TO RECEIVE U.S. OFFICIALS IN RUSSIA - PESKOV

PUTIN SPOKE OF NEED TO ELIMINATE ROOT CAUSES OF UKRAINE CONFLICT IN PHONE CALL WITH TRUMP, AGREED THAT LASTING SETTLEMENT

PESKOV: TRUMP ASSURES PUTIN THAT U.S. FULFILLING ALL AGREEMENTS REACHED WITH REGARD TO SWAP OF RUSSIAN, U.S. CITIZENS

Just the night prior, American school teacher Marc Fogel arrived in Washington, fresh out of a 3+ year stint in Russian prison, after a successful prisoner exchange. Walz has declared this an act of good faith from Putin. What's clear is that things are moving fast.

Ukraine dollar bonds are rallying on news of the call, and have seen price rise dramatically since the restructuring last year - and since Trump was elected....

So it seems the market is growing more optimistic now that peace is close.

Polymarket's odds of Trump ending the war within 90 days are also rising...

At the same time, Pete Hegseth is in Brussels and has declared that NATO membership for Ukraine is off the table.

* * *

Geopolitical observer Arnaud Bertrand writes...

This is a monumental shift: the U.S. finally renounces NATO membership for Ukraine after 17 years of trying... This is no cause for celebration, it's tragic really: had this position been taken in late 2021 instead of doubling down on NATO expansion, the war and its hundreds of thousands of casualties would have undoubtedly been avoided.

And we know the U.S. could have taken this position then, because they do it now. The intolerable cost of hubris, which of course no-one will pay a price for except all those who died in this senseless and easily avoidable war.

https://www.zerohedge.com/geopolitical/trump-has-lengthy-highly-productive-call-putin-immediately-end-war

Anticipating Approval, Gilead Gears Up for Mid-Year Launch for Lenacapavir PrEP

 

Gilead beat consensus estimates in Q4 with $7.6 billion in revenue, driven largely by its HIV drug Biktarvy and CAR T therapies Trodelvy and Yescarta.

As it awaits FDA approval, Gilead is laying the groundwork for the launch of its antiretroviral drug lenacapavir as a pre-exposure prophylactic for HIV by mid-2025.

The pharma made the announcement during its fourth-quarter and full-year earnings call on Tuesday, with Chief Commercial Officer Johanna Mercier saying that preparations “are well underway” in the U.S. Gilead expects to make lenacapavir available “this summer,” she added.

Demand for lenacapavir is expected to be high. In a note to investors on Tuesday, Jefferies analysts wrote that the HIV community is already “educated” regarding PrEP, as per Gilead. Patients are ready for lenacapavir and the pharma is “already seeing increases in HIV doc appointments scheduling” in anticipation of the drug’s potential approval in June, according to the Jefferies note.

The FDA is currently reviewing Gilead’s drug application for lenacapavir, which it filed in December 2024 and backed with data from the Phase III PURPOSE clinical development program. Lenacapavir was awarded the FDA’s Breakthrough Therapy designation in October 2024, which would accelerate its review process, though Gilead has yet to disclose a target action date for the antiviral drug.

Late-stage data paint a strong efficacy profile for lenacapavir. A readout from PURPOSE 1, released in June 2024, showed that in a cohort of 2,134 women, a twice-yearly regimen of lenacapavir led to zero cases of HIV infection. This 100% prevention efficacy surpassed even that of the oral Truvada and Descovy, both also from Gilead.

A few months later, in September, the pharma released data from PURPOSE 2, touting a 96% risk reduction against HIV infection in cisgender men, transgender men, transgender women and gender non-binary individuals who have sex with partners assigned male at birth.

“Access will play out over the next few months of the launch. We’re assuming about 75% or so access by six months, maybe about 90% by 12 months,” Mercier said on the investor call, though she noted that roll-out might “take a little bit of time in the first early months.”

“We feel incredibly confident that lenacapavir is going to have an impact in our communities in 2025 and, obviously, even more meaningful in ‘26 and beyond,” she added.

In the fourth quarter, Gilead reported a 6% year-on-year increase in revenue to $7.6 billion, surpassing the consensus of $7.1 billion. For the full year, the pharma’s revenue jumped 6% to $28.8 billion. Key growth drivers include the HIV pill Biktarvy, which earned $3.77 billion in the quarter versus the $3.47 billlion consensus, and the CAR T therapies Trodelvy and Yescarta, which raked in $365 million and $390 million, respectively.

In an investor note on Tuesday, analysts at BMO Capital Markets called Gilead’s Q4 performance “a solid end to 2024” that gives the pharma a strong positioning into 2025, “with a focus on the launch of long-acting PrEP.” In particular, the BMO analysts noted that the 16% year-on-year growth of Gilead’s HIV franchise points to its “continued dominance in the space.”

Looking ahead to the year, Gilead projects product sales of between $28.2 billion and $28.6 billion.

https://www.biospace.com/business/anticipating-approval-gilead-gears-up-for-mid-year-launch-for-lenacapavir-prep